eLife

Latest preprint reviews

1. Parabrachial CGRP neurons modulate active defensive behavior under a naturalistic threat

   This article has 5 authors:

   1. Gyeong Hee Pyeon
   2. Hyewon Cho
   3. Byung Min Chung
   4. June-Seek Choi
   5. Yong Sang Jo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work advances our understanding of parabrachial CGRP threat function. The evidence supporting CGRP aversive outcome signaling is solid, while the evidence for cue signaling and fear behavior generation is incomplete. The work will be of interest to neuroscientists studying defensive behaviors.

   Reviewed by eLife

2. An integrin centered complex coordinates ion transport and pH to regulate f-actin organization and cell migration in breast cancer

   This article has 12 authors:

   1. Chiara Capitani
   2. Jessica Iorio
   3. Elena Lastraioli
   4. Claudia Duranti
   5. Giacomo Bagni
   6. Ginevra Chioccioli Altadonna
   7. Rossella Colasurdo
   8. Giorgia Scarpellino
   9. Scott P. Fraser
   10. Andrea Becchetti
   11. Mustafa B. A. Djamgoz
   12. Annarosa Arcangeli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding on the identification of a complex consisting of NHE1, hERG1, β1/integrin and NaV1.5 on the membrane of breast cancer cells. The evidence supporting the claims of the authors is somewhat incomplete. The inclusion of clarification of some experimental design and the amendment of cropping Western blot data would have strengthened the study. The work will be of interest to scientists working on breast cancer.

   Reviewed by eLife

3. Dapagliflozin improves endothelial integrity and hemodynamics in endotoxin treated mice through an apolipoprotein M dependent pathway

   This article has 18 authors:

   1. Carla Valenzuela Ripoll
   2. Zhen Guo
   3. Tripti Kumari
   4. Kana N. Miyata
   5. Mualla Ozcan
   6. Ahmed Diab
   7. Amanda Girardi
   8. Li He
   9. Attila Kovacs
   10. Carla Weinheimer
   11. Jess Nigro
   12. Jan Oscarsson
   13. Russell Esterline
   14. Joel Schilling
   15. Mikhail Kosiborod
   16. Christina Christoffersen
   17. Jaehyung Cho
   18. Ali Javaheri

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     SGLT2 inhibitors (SGLT2i) have assumed important roles in reducing cardiovascular risk, particularly in those with diabetes. It has become appreciated that its protective effects are likely beyond their ability to lower blood sugar levels. This research presents a novel approach to studying the SGLT2i mechanism of action which is yet to be fully elucidated.

   Reviewed by eLife

4. Marcks and Marcks-like 1 proteins promote spinal cord development and regeneration in Xenopus

   This article has 3 authors:

   1. Mohamed El Amri
   2. Abhay Pandit
   3. Gerhard Schlosser

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work addresses the role of Marcks/Markcksl during spinal cord development and regeneration. The study is exceptional in combining molecular approaches to understand the mechanisms of tissue regeneration with behavioural assays, which is not commonly employed in the field. The data presented is convincing and comprehensive, using many complementary methodologies.

   Reviewed by eLife

5. Serum metabolome indicators of early childhood development in the Brazilian National Survey on Child Nutrition (ENANI-2019)

   This article has 14 authors:

   1. Marina Padilha
   2. Victor Nahuel Keller
   3. Paula Normando
   4. Raquel M Schincaglia
   5. Nathalia C Freitas-Costa
   6. Samary SR Freire
   7. Felipe M Delpino
   8. Inês RR de Castro
   9. Elisa MA Lacerda
   10. Dayana R Farias
   11. Zachary Kroezen
   12. Meera Shanmuganathan
   13. Philip Britz-Mckibbin
   14. Gilberto Kac

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work advances our understanding of factors influencing early childhood development. The large sample size and methodology applied make the findings of this study convincing; however, support for some of the claims made by the authors is incomplete. The work will be of interest to researchers in developmental science and early childhood pediatrics.

   Reviewed by eLife

6. Error prediction determines the coordinate system used for the representation of novel dynamics

   This article has 2 authors:

   1. Raz Leib
   2. David Franklin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a valuable new perspective on how motor learning occurring in one state generalizes to new states (for example, a different limb posture). The proposed model improves upon previous theories in its ability to predict patterns of generalization, but evidence supporting this specific proposed model over possible alternatives is incomplete. The newly proposed theory appears promising but would be more convincing if its conceptual and theoretical basis were clearer and more rigorously derived.

   Reviewed by eLife

7. Balancing safety and efficiency in human decision-making

   This article has 4 authors:

   1. Pranav Mahajan
   2. Shuangyi Tong
   3. Sang Wan Lee
   4. Ben Seymour

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work describes results from a set of simulation and empirical studies of a set-up assessing exploratory behavior in a potentially rewarding environment that contains danger. The core idea is that an instrumental agent can be helped to be both effective and safe, thus avoiding excessive danger, during exploratory behavior, if the influence of an independent Pavlovian fear is flexibly gated based on uncertainty. This work is grounded in previous foundational work on Pavlovian control of instrumental choice, and significantly extends prior work showing that the impact of Pavlovian reward biases can be flexibly gated. The conclusion that safe but effective exploration can be achieved based on a flexibly weighted combination of a Pavlovian and an instrumental agent is convincing.

   Reviewed by eLife

8. Secreted exosomes induce filopodia formation

   This article has 11 authors:

   1. Caitlin McAtee
   2. Mikin R Patel
   3. Daisuke Hoshino
   4. Bong Hwan Sung
   5. Ariana K von Lersner
   6. Mingjian Shi
   7. Nan Hyung Hong
   8. Anna Young
   9. Evan Krystofiak
   10. Andries Zijlstra
   11. Alissa M Weaver

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this important manuscript, the authors reveal novel findings on the role of exosomes in regulating filopodia formation. Filopodia are crucial for various cellular processes, including migration, polarization, directional sensing, and the formation of neuronal synapses. The authors convincingly demonstrate that exosomes, particularly those enriched with the protein THSD7A, play a significant role in promoting filopodia formation in both cancer cells and neurons.

   Reviewed by eLife

9. The flexible stalk domain of sTREM2 modulates its interactions with brain-based phospholipids

   This article has 6 authors:

   1. David Saeb
   2. Emma E Lietzke
   3. Daisy I Fuchs
   4. Emma C Aldrich
   5. Kimberley D Bruce
   6. Kayla G Sprenger

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful manuscript addresses some key molecular mechanisms on the neuroprotective roles of soluble TREM2 in neurodegenerative diseases. The study will advance our understanding of TREM2 mutations, particularly on the damaging effect of known TREM2 mutations, and also provides solid evidence why soluble TREM2 can antagonize Aβ aggregation.

   Reviewed by eLife

10. Scale matters: Large language models with billions (rather than millions) of parameters better match neural representations of natural language

    This article has 16 authors:

    1. Zhuoqiao Hong
    2. Haocheng Wang
    3. Zaid Zada
    4. Harshvardhan Gazula
    5. David Turner
    6. Bobbi Aubrey
    7. Leonard Niekerken
    8. Werner Doyle
    9. Sasha Devore
    10. Patricia Dugan
    11. Daniel Friedman
    12. Orrin Devinsky
    13. Adeen Flinker
    14. Uri Hasson
    15. Samuel A Nastase
    16. Ariel Goldstein

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable study investigates how the size of an LLM may influence its ability to model the human neural response to language recorded by ECoG. Overall, solid evidence is provided that larger language models can better predict the human ECoG response. Further discussion would be beneficial as to how the results can inform us about the brain or LLMs, especially about the new message that can be learned from this ECoG study beyond previous fMRI studies on the same topic. This study will be of interest to both neuroscientists and psychologists who work on language comprehension and computer scientists working on LLMs.

    Reviewed by eLife