eLife

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1. We couldn't get details of this article at this time:
   10.1101/2024.08.31.610597

2. We couldn't get details of this article at this time:
   10.1101/2024.11.17.623901

3. We couldn't get details of this article at this time:
   10.1101/2024.11.06.622285

4. We couldn't get details of this article at this time:
   10.1101/2024.08.29.610420

5. Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species

   This article has 13 authors:

   1. Man Zhu
   2. Meng Ma
   3. Lunan Luo
   4. Feiyang Li
   5. Jiashun Zheng
   6. Yan Pan
   7. Lu Yang
   8. Ying Xiao
   9. Ziyan Wang
   10. Bo Xian
   11. Yi Zheng
   12. Hao Li
   13. Jing Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Building on earlier evidence that Topoisomerase 2 depletion can extend yeast lifespan, the authors present convincing data demonstrating that reduced Top2 levels confer significant longevity benefits in C. elegans and mice. They show that these benefits encompass not only extended survival but also improved healthspan and mitigation of aging phenotypes, supported by robust transcriptomic, epigenetic, and histological analyses. While the exact mechanistic underpinnings-such as the potential connection to classical aging pathways and the selective down-regulation of genes with active promoters-remain to be fully elucidated, the breadth of these important findings strongly indicates a conserved role for Top2 in aging regulation.

   Reviewed by eLife

6. TET2-mediated epigenetic modification promotes stress senescence of pancreatic β cells in type 2 diabetes mellitus

   This article has 6 authors:

   1. Weijuan Cai
   2. Qingqing Song
   3. Xiaoqing Mo
   4. Huaqian Li
   5. Yuling Song
   6. Liang Yin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts are novel and of interest, the study presents incomplete evidence to fully support its main conclusions.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2024.08.27.609839

8. We couldn't get details of this article at this time:
   10.1101/2024.11.05.622187

9. The title and authors for this article are not available from our external data provider yet:
   10.31219/osf.io/kcwm8

10. We couldn't get details of this article at this time:
    10.1101/2024.11.10.622876