eLife

Latest preprint reviews

1. Increased bone inflammation in type 2 diabetes and obesity correlates with Wnt signaling downregulation and reduced bone strength

   This article has 15 authors:

   1. Giulia Leanza
   2. Malak Faraj
   3. Francesca Cannata
   4. Viola Viola
   5. Niccolò Pellegrini
   6. Flavia Tramontana
   7. Claudio Pedone
   8. Gianluca Vadalà
   9. Alessandra Piccoli
   10. Rocky Strollo
   11. Francesca Zalfa
   12. Roberto Civitelli
   13. Mauro Maccarrone
   14. Rocco Papalia
   15. Nicola Napoli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a convincing paper that addresses topics important in our understanding of how inflammatory markers are modulated in both obesity and type 2 diabetes and their effects on Wnt signaling mediators in human bone. There are changes in bone at the tissue level in these 2 common metabolic disorders that ultimately lead to compromised bone strength. These data will be critical to our understanding of the pathophysiology of skeletal fragility in obesity and diabetes.

   Reviewed by eLife

2. STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer

   This article has 8 authors:

   1. Huan Fang
   2. Huichun Liang
   3. Chuanyu Yang
   4. Dewei Jiang
   5. Qianmei Luo
   6. Wen-Ming Cao
   7. Huifeng Zhang
   8. Ceshi Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study conducted by Fang et al. offers significant and fundamental insights, notably enhancing our understanding of angiogenesis. While some of the claims are supported by convincing experimental approaches, others lack sufficient validation. Additionally, there are instances where critical experimental controls appear to be absent.

   Reviewed by eLife

3. Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s disease

   This article has 10 authors:

   1. Zachary Gaertner
   2. Cameron Oram
   3. Amanda Schneeweis
   4. Elan Schonfeld
   5. Cyril Bolduc
   6. Chuyu Chen
   7. Daniel Dombeck
   8. Loukia Parisiadou
   9. Jean-Francois Poulin
   10. Rajeshwar Awatramani

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study combines single nucleus transcriptional profiling with spatial transcriptomics to identify and map heterogeneity among dopamine neurons in the mouse ventral midbrain. The compelling results separate dopamine neurons into three broad families that have unique (yet overlapping) spatial distribution within the ventral tegmental area and substantia nigra, and also identify population-specific changes in a LRRK2 mouse model of Parkinson's Disease. The creation of a public-facing app where the snRNA-seq data can be investigated by anyone is a major strength.

   Reviewed by eLife

4. HIF1A-mediated pathways promote euploid cell survival in chromosomally mosaic embryos

   This article has 3 authors:

   1. Estefania Sanchez-Vasquez
   2. Marianne E Bronner
   3. Magdalena Zernicka-Goetz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Sanchez-Vasquez et al establish an innovative approach to induce aneuploidy in preimplantation embryos. This important study extends the author's previous publications evaluating the consequences of aneuploidy in the mammalian embryo. In this work, the authors investigate the developmental potential of aneuploid embryos and characterize changes in gene expression profiles under normoxic and hypoxic culture conditions. Using a solid methodology they identify sensitivity to Hif1alpha loss in aneuploid embryos, and in further convincing experiments they assess how levels of DNA damage and DNA repair are altered under hypoxic and normoxic conditions.

   Reviewed by eLife, preLights

5. An improved bacterial single-cell RNA-seq reveals biofilm heterogeneity

   This article has 7 authors:

   1. Xiaodan Yan
   2. Hebin Liao
   3. Chenyi Wang
   4. Chun Huang
   5. Wei Zhang
   6. Chunming Guo
   7. Yingying Pu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work introduces an important new method for depleting ribosomal RNA from bacterial single-cell RNA sequencing libraries, demonstrating its applicability for studying heterogeneity in microbial biofilms. The findings provide convincing evidence for a distinct subpopulation of cells at the biofilm base that upregulates PdeI expression. Future studies exploring the functional relationship between PdeI and c-di-GMP levels, along with the roles of co-expressed genes within the same cluster, could further enhance the depth and impact of these conclusions.

   Reviewed by eLife

6. Information, certainty, and learning

   This article has 2 authors:

   1. Justin A Harris
   2. Charles Randy Gallistel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper presents fundamental research showing that the acquisition and expression of Pavlovian conditioned responding are lawfully related to temporal characteristics of an animal's conditioning experience. It showcases a rigorous experimental design, several different approaches to data analysis, careful consideration of prior literature, and a thorough introduction. The evidence supporting the conclusions is compelling. The paper will have a general appeal to those interested in the behavioral and neural analysis of Pavlovian conditioning.

   Reviewed by eLife

7. CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells

   This article has 16 authors:

   1. Xiaoyu Meng
   2. Yezhang Zhu
   3. Kuai Liu
   4. Yuxi Wang
   5. Xiaoqian Liu
   6. Chenxin Liu
   7. Yan Zeng
   8. Shuai Wang
   9. Xianzhi Gao
   10. Xin Shen
   11. Jing Chen
   12. Sijue Tao
   13. Qianying Xu
   14. Linjia Dong
   15. Li Shen
   16. Lie Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents important findings on the role of CXXC-finger protein 1 in regulatory T cell gene regulation and function. The evidence supporting the authors' claims is convincing, with mostly state-of-the-art technology. The work will be of relevance to immunologists interested in regulatory T cell biology and autoimmunity.

   Reviewed by eLife

8. Emergence of alternative stable states in microbial communities undergoing horizontal gene transfer

   This article has 3 authors:

   1. Juken Hong
   2. Wenzhi Xue
   3. Teng Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript offers valuable theoretical predictions on how horizontal gene transfer (HGT) can lead to alternative stable states in microbial communities. Using a modeling framework, solid theoretical evidence is provided to support the claimed role of HGT. However, given that the model has many degrees of freedom, a more comprehensive analysis of the role of different parameters could strengthen the study. Additionally, potential interactions between plasmids that carry out HGT are not discussed in the model. This paper would be of interest to researchers in microbiology, ecology, and evolutionary biology.

   Reviewed by eLife

9. Layer 6 corticocortical neurons are a major route for intra- and interhemispheric feedback

   This article has 3 authors:

   1. Simon Weiler
   2. Manuel Teichert
   3. Troy W Margrie

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study compares the cortical projections to primary motor and sensory areas originating from the ipsilateral and contralateral hemispheres. Results show that, while there is substantial symmetry between the two hemispheres regarding the areas sending projections to these primary cortical areas, contra-hemispheric projections had more inputs from layer 6 neurons than ipsi-projecting ones. The evidence is compelling and the conclusions are supported by rigorous analyses.

   Reviewed by eLife

10. Synaptic cell adhesion molecule Cdh6 identifies a class of sensory neurons with novel functions in colonic motility

    This article has 9 authors:

    1. Julieta Gomez-Frittelli
    2. Gabrielle Frederique Devienne
    3. Lee Travis
    4. Melinda A Kyloh
    5. Xin Duan
    6. Tim J Hibberd
    7. Nick J Spencer
    8. John R Huguenard
    9. Julia A Kaltschmidt

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This important study characterizes the molecular signatures and function of a type of enteric neuron (IPAN) in the mouse colon, identifying molecular markers (Cdh6 and Cdh8) for these cells. A battery of compelling and comprehensive experimental findings suggests data from other species are likely translatable to mice, bridging the abundant literature from humans and other mammals into this experimentally tractable animal model. This work will be of interest to scientists studying the motor control of the colon and more generally the enteric neuromuscular system.

    Reviewed by eLife