Latest preprint reviews

  1. Systematic analysis of transcription factor combinatorial binding uncovers TEAD1 as an antagonist of tissue-specific transcription factors in human organogenesis

    This article has 6 authors:
    1. Araceli Garcia-Mora
    2. Joshua Mallen
    3. Peyman Zarrineh
    4. Neil Hanley
    5. Dave Gerrard
    6. Nicoletta Bobola
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study presents a pipeline for discovering cooperative transcription factor (TF) interactions that regulate development, and applies this pipeline in a systematic investigation of TF co-regulation in 11 human embryonic tissues. The authors provide overall solid bioinformatics and experimental support for their findings: although they make a convincing argument for the role of TEAD factors as co-repressors of regulatory activity with tissue-specific TFs, other aspects of the study would benefit from additional validation. This work would be of interest to cell biologists focused on development or on discovery of TF relationships.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  2. Theory of non-dilute binding and surface phase separation applied to membrane-binding proteins

    This article has 6 authors:
    1. Xueping Zhao
    2. Daxiao Sun
    3. Giacomo Bartolucci
    4. Anthony A Hyman
    5. Alf Honigmann
    6. Christoph A Weber
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study presents a compelling theoretical framework for understanding condensation or phase separation of membrane-bound proteins, with a focus on the organization of tight junction components. By incorporating non-dilute binding effects into thermodynamic models and validating the model's predictions with in vitro experiments on the tight junction protein ZO-1, the authors provide a quantitative tool that combines theory and experiments and will help researchers in the field quantitatively interpret their findings. Given that phase separation of membrane bound molecules is becoming key in signaling, spanning from immune signaling to cell-cell adhesion, this work will be of broad interest for cell biologists and biophysicists.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
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