eLife

Latest preprint reviews

1. Brain-Cognitive Gaps in relation to Dopamine and Health-related Factors: Insights from AI-Driven Functional Connectome Predictions

   This article has 10 authors:

   1. Morteza Esmaeili
   2. Erin Beate Bjørkeli
   3. Robin Pedersen
   4. Farshad Falahati
   5. Jarkko Johansson
   6. Kristin Nordin
   7. Nina Karalija
   8. Lars Bäckman
   9. Lars Nyberg
   10. Alireza Salami

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This multimodal neuroimaging study leverages fMRI, PET, and deep learning to predict memory performance. The authors introduce the brain-cognition gap to link these different imaging modalities to cognition and evaluate their results in two independent cohorts. The results are a valuable addition to the literature and will be of interest to neuroscientists working at the interface of cognition, neuroimaging, and computational modeling. However, the evidence supporting the conclusions remains incomplete.

   Reviewed by eLife

2. Rapid riparian ecosystem recovery in low-latitudinal North China following the end-Permian mass extinction

   This article has 7 authors:

   1. Wenwei Guo
   2. Li Tian
   3. Daoliang Chu
   4. Wenchao Shu
   5. Michael J Benton
   6. Jun Liu
   7. Jinnan Tong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a well-written important paper on the recovery of fauna and flora following the end-Permian extinction event in several continental sites in northern China. The convincing conclusion, a rapid recovery in tropical riparian ecosystems following a short phase of hostile environments and depauperate biota, is supported by an impressive amount of data from sedimentology, body fossils of animals and plants, and especially trace fossils.

   Reviewed by eLife

3. High-Resolution Genome-Wide Maps Reveal Widespread Presence of Torsional Insulation

   This article has 6 authors:

   1. Porter M Hall
   2. Lauren A Mayse
   3. Lu Bai
   4. Marcus B Smolka
   5. B Franklin Pugh
   6. Michelle D Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The Twin Domain model proposed by Lui and Wang proposing that twin supercoiling domains of DNA emerge during transcription were first described decades ago, but direct experimental evidence has been challenging to obtain. Here, the authors make a fundamental contribution by directly measuring DNA torsion in cells using a photoactivatable intrastrand cross-linker compared to controls. They gather compelling data using this clever method, which provides direct evidence in support of the twin-supercoiled domain model, for torsional effects at transcription start and end sites, and thereby uncover novel features of higher order structure of chromatin in yeast. These data are exciting, and the tools will be of interest to anyone studying chromosome structure and gene regulation.

   Reviewed by eLife

4. Oxytocin receptor controls promiscuity and development in prairie voles

   This article has 23 authors:

   1. Ruchira Sharma
   2. Kristen M Berendzen
   3. Amanda Everitt
   4. Belinda Wang
   5. Gina Williams
   6. Shuyu Wang
   7. Kara Quine
   8. Rose D Larios
   9. Kimberly LP Long
   10. Nerissa Hoglen
   11. Bibi Alika Sulaman
   12. Marie C Heath
   13. Michael Sherman
   14. Robert Klinkel
   15. Angela Cai
   16. Denis Galo
   17. Lizandro Chan Caamal
   18. Nastacia L Goodwin
   19. Annaliese Beery
   20. Karen L Bales
   21. Katherine S Pollard
   22. Arthur Jeremy Willsey
   23. Devanand S Manoli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents an important finding regarding how partner preference formation and pair bonding behavior are related to the oxytocin receptor gene expression in the NAc and paraventricular nucleus of the hypothalamus in prairie voles. The evidence supporting this claim is solid but could benefit from increased sample size and more thorough behavioral phenotyping. This study will be of interest to social scientists and neuroscientists who work on pair bonding and oxytocin.

   Reviewed by eLife

5. Global risk mapping of highly pathogenic avian influenza H5N1 and H5Nx in the light of epidemic episodes occurring from 2020 onwards

   This article has 10 authors:

   1. Marie-Cécile Dupas
   2. Maria F Vincenti-Gonzalez
   3. Madhur Dhingra
   4. Claire Guinat
   5. Timothée Vergne
   6. William Wint
   7. Guy Hendrickx
   8. Cedric Marsboom
   9. Marius Gilbert
   10. Simon Dellicour

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This global study compares environmental niche model outputs of avian influenza pathogen niche constructed for two distinct periods, and uses differences between those outputs to suggest that the changed case numbers and distribution relate to intensification of chicken and duck farming, and extensive cultivation. While a useful update to existing niche models of highly pathogenic avian influenza, the justification for the use of environmental niche models to explore land cover change as a driver of changed case epidemiology is incomplete.

   Reviewed by eLife

6. Dual transcranial electromagnetic stimulation of the precuneus boosts human long-term memory

   This article has 10 authors:

   1. Ilaria Borghi
   2. Lucia Mencarelli
   3. Michele Maiella
   4. Elias Paolo Casula
   5. Matteo Ferraresi
   6. Francesca Candeo
   7. Elena Savastano
   8. Martina Assogna
   9. Sonia Bonnì
   10. Giacomo Koch

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work presents important findings suggesting that a combination of transcranial stimulation approaches applied for a short period could improve memory performance. Solid methods and evidence, in line with current standards for non-invasive stimulation and recording, are included to broadly support the main findings. The results potentially have implications for non-invasive enhancement of cognitive functions.

   Reviewed by eLife

7. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2309.15174v2

8. The Drosophila EGF domain protein uninflatable sets the switch between wrapping glia growth and axon wrapping instructed by Notch

   This article has 5 authors:

   1. Marie Baldenius
   2. Steffen Kautzmann
   3. Rita Kottmeier
   4. Jaqueline Zipfel
   5. Christian Klämbt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study identifies a new key factor in orchestrating the process of glial wrapping of axons in Drosophila wandering larvae. The evidence supporting the claims of the authors is convincing and the EM studies are of outstanding quality. After the revision, the authors have addressed most of the concerns and the manuscript has been significantly improved. Both reviewers have agreed on the significance of the work. The work will be of interest to neuroscientists working on glial cell biology.

   Reviewed by eLife

9. Enalapril mitigates senescence and aging-related phenotypes in human cells and mice via pSmad1/5/9-driven antioxidative genes

   This article has 11 authors:

   1. Wencong Lyu
   2. Haochen Wang
   3. Zhehao Du
   4. Ran Wei
   5. Jianuo He
   6. Fanju Meng
   7. Jinlong Bi
   8. Lijun Zhang
   9. Chao Zhang
   10. Yiting Guan
   11. Wei Tao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable insights into the anti-senescence effects of enalapril, identifying pSmad1/5/9 signaling and associated antioxidant pathways as key mediators of its physiological benefits in aged mice. The authors present solid experimental evidence across both in vitro and in vivo systems, demonstrating improved organ function and reduced senescence markers following treatment. Overall, the work supports the repurposing potential of enalapril in aging research and expands understanding of its molecular targets.

   Reviewed by eLife

10. The title and authors for this article are not available from our external data provider yet:
    10.1101/2024.05.23.595569