eLife

Latest preprint reviews

1. A Commander-independent function of COMMD3 in endosomal trafficking

   This article has 5 authors:

   1. Galen T Squiers
   2. Chun Wan
   3. James Gorder
   4. Harrison Puscher
   5. Jingshi Shen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study explores the mechanisms underlying the maintenance of cell surface protein levels. The authors present solid evidence to support their claims, though the addition of certain validation experiments could have further strengthened the conclusions. This work will be of particular interest to cell biologists focused on membrane trafficking.

   Reviewed by eLife

2. Negative regulation of miRNA sorting into EVs is mediated by the capacity of RBP PCBP2 to impair the SYNCRIP-dependent miRNA loading

   This article has 14 authors:

   1. Francesco Marocco
   2. Sabrina Garbo
   3. Claudia Montaldo
   4. Alessio Colantoni
   5. Luca Quattrocchi
   6. Gioele Gaboardi
   7. Giovanna Sabarese
   8. Carla Cicchini
   9. Mario Lecce
   10. Alessia Carnevale
   11. Rossella Paolini
   12. Gian Gaetano Tartaglia
   13. Cecilia Battistelli
   14. Marco Tripodi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript makes a valuable contribution to the field by uncovering a molecular mechanism for miRNA intracellular retention, mediated by the interaction of PCBP2, SYNCRIP, and specific miRNA motifs. The findings are convincing and advance our understanding of RNA-binding protein-mediated miRNA sorting, providing deeper insights into miRNA dynamics.

   Reviewed by eLife

3. Newly discovered and conserved role of IgM against viral infection in an early vertebrate

   This article has 10 authors:

   1. Weiguang Kong
   2. Xinyou Wang
   3. Guangyi Ding
   4. Peng Yang
   5. Yong Shi
   6. Chang Cai
   7. Xinyi Yang
   8. Gaofeng Cheng
   9. Fumio Takizawa
   10. Zhen Xu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The manuscript is an important study which aims to demonstrate the conserved and crucial role of IgM in both systemic and mucosal antiviral immunity in teleost, challenging the established differential roles of IgT and IgM. The strength of the evidence is solid and supported by a combination of in vivo studies, viral infection models, and complementary in vitro assays. In the current version, authors validate the MoAb against IgM

   Reviewed by eLife

4. Clathrin-independent endocytosis and retrograde transport in cancer cells tune immune synapse organization and CD8 T cell response

   This article has 12 authors:

   1. Shiqiang Xu
   2. Alix Buridant
   3. Thibault Hirsch
   4. Céline Duhamel
   5. Benjamin Ledoux
   6. Massiullah Shafaq-Zadah
   7. Estelle Dransart
   8. Louise Thines
   9. Ludger Johannes
   10. Pierre Van der Bruggen
   11. Pierre Morsomme
   12. Henri-François Renard

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study now provides solid evidence for a role of EndoA3-mediated trafficking of ICAM-1 to the immune synapse with T cells. The study will be valuable to those studying cell-cell communication in the immune system, and opens additional questions regarding the mechanisms involved and how other adhesion ligands are regulated.

   Reviewed by eLife

5. Balancing stability and flexibility when reshaping archaeal membranes

   This article has 5 authors:

   1. Miguel Amaral
   2. Felix Frey
   3. Xiuyun Jiang
   4. Buzz Baum
   5. Anđela Šarić

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental study characterizes the mechanics and stability of bolalipids from archaeal membranes using a minimalist, physics-based computational model. The authors present a robust mesoscale model of bolalipids-containing membranes, systematically evaluating it across diverse membrane configurations. The results are compelling, demonstrating that the incorporation of bolalipids and regular bilayer lipids in archaeal membranes significantly enhances membrane fluidity and structural stability.

   Reviewed by eLife, Arcadia Science

6. Neurons in the medial prefrontal cortex are involved in spatial tuning and signaling upcoming choice independently from hippocampal sharp-wave ripples

   This article has 2 authors:

   1. Hanna den Bakker
   2. Fabian Kloosterman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study reports analyses of Neuropixel recordings in the medial prefrontal cortex and hippocampus of rats in a spatial navigation trial, focusing on classifying prefrontal neurons based on SWR modulation and anatomical location. Reviewers were unconvinced by the presented evidence for the claim that distinct populations of mPFC neurons participate in non-local ensemble representations during SWR and non-SWR periods, and were unconvinced by the presented evidence for a previously unrecognized anatomical distinction between these populations. Further analyses might strengthen the incomplete evidence for some conclusions, and some of the strong claims of the paper should likely be moderated.

   Reviewed by eLife

7. Novel and optimized mouse behavior enabled by fully autonomous HABITS: Home-cage assisted behavioral innovation and testing system

   This article has 6 authors:

   1. Bowen Yu
   2. Penghai Li
   3. Haoze Xu
   4. Yueming Wang
   5. Kedi Xu
   6. Yaoyao Hao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript describes a novel approach for assessing cognitive function in freely moving mice in their home-cage, without human involvement. The authors provide convincing evidence in support of the tasks they developed to capture a variety of complex behaviors and demonstrate the utility of a machine learning approach to expedite the acquisition of task demands. This work is important given its potential utility for other investigators interested in studying mouse cognition.

   Reviewed by eLife

8. Sexual failure decreases sweet taste perception in male Drosophila via dopaminergic signaling

   This article has 4 authors:

   1. Gaohang Wang
   2. Wei Qi
   3. Rui Huang
   4. Liming Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable findings on the effects of mating experience on sweet taste perception. The data as presented provide convincing evidence that the dopaminergic signaling-mediated reward system underlies this mating state-dependent behavioral modulation. The work will interest neuroscientists and particularly biologists working on neuromodulation and the effects of internal states on sensory perception.

   Reviewed by eLife

9. Afadin-deficient mouse retinas exhibit severe neuronal lamination defects but preserve visual functions

   This article has 15 authors:

   1. Akiko Ueno
   2. Konan Sakuta
   3. Hiroki Ono
   4. Aki Hashio
   5. Haruki Tokumoto
   6. Mikiya Watanabe
   7. Taketo Nishimoto
   8. Toru Konishi
   9. Yuki Emori
   10. Shunsuke Mizuno
   11. Mao Hiratsuka
   12. Jun Miyoshi
   13. Yoshimi Takai
   14. Masao Tachibana
   15. Chieko Koike

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study demonstrates that conditional knockout of afadin disrupts retinal laminar organization and reduces the number of photoreceptors, while preserving certain aspects of retinal ganglion cell structure and light responsiveness. The work is valuable and well-supported by revised figures and comprehensive data on retinal cell types, lamination patterns, and visual functio. The findings are solid and intriguing, and the study provides insights into the relationship between retinal lamination and neural circuit function.

   Reviewed by eLife

10. A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality

    This article has 6 authors:

    1. Seetha Krishnan
    2. Can Dong
    3. Heather Ratigan
    4. Denisse Morales-Rodriguez
    5. Chery Cherian
    6. Mark Sheffield

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This useful study presents a virtual reality-based contextual fear conditioning paradigm for head-fixed mice. Solid evidence supports the claim that the reported methods provide a reliable paradigm for studying contextual fear conditioning in head-fixed mice. The approach provides a way to perform multiphoton imaging of neural circuits, and other techniques that are typically performed in head-fixed animals, during behaviors that have traditionally been studied in freely moving animals.

    Reviewed by eLife