Latest preprint reviews

1. Olfactory cortical outputs recruit and shape distinct brain-wide spatiotemporal networks

   This article has 9 authors:

   1. Teng Ma
   2. Xunda Wang
   3. Xuehong Lin
   4. Junjian Wen
   5. Linshan Xie
   6. Pek-Lan Khong
   7. Peng Cao
   8. Ed X Wu
   9. Alex TL Leong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study partially fills the gap in the knowledge of olfaction at the level of the Anterior Olfactory Nucleus (AON) and Piriform Cortex with functional magnetic resonance imaging, electrophysiology, and modeling. The methods used are convincing. Some of the findings confirm ongoing hypotheses, such as the behavioral importance of AON for odor source discrimination. Other results shed light on the dynamics of the connection between the olfactory system and the rest of the brain.

   Reviewed by eLife

2. A SMARTR workflow for multi-ensemble atlas mapping and brain-wide network analysis

   This article has 8 authors:

   1. Michelle Jin
   2. Simon O Ogundare
   3. Marcos Lanio
   4. Sophia Sorid
   5. Alicia R Whye
   6. Sofia Leal Santos
   7. Alessandra Franceschini
   8. Christine A Denny

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study describes a new analysis strategy to compare active neurons during behavioral tasks across the brain. This is significant because analysing how different brain areas are active during behavior requires better methods. The evidence provided in support of the method is solid. Although useful now, the work may increase its significance following appropriate revisions.

   Reviewed by eLife

3. Selective attention and sensitivity to auditory disturbances in a virtually-real Classroom: Comparison of adults with and without AD(H)D

   This article has 7 authors:

   1. Orel Levy
   2. Shirley Libman Hackmon
   3. Yair Zvilichovsky
   4. Adi Korisky
   5. Aurelie Bidet-Caulet
   6. Julie B Schweitzer
   7. Elana Zion Golumbic

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study investigates how AD(H)D affects attention using neural and physiological measures in a Virtual Reality (VR) environment. Solid evidence is provided that individuals diagnosed with AD(H)D differ from control participants in both the encoding of the target sound and the encoding of acoustic interference. The VR paradigm here can potentially bridge lab experiments and real-life experiments. However, the reviewers identified a few potential technical issues that will need to be verified and discussed.

   Reviewed by eLife

4. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2406.03212v1

5. Cardiac Fibroblasts regulate myocardium and coronary vasculature development via the collagen signaling pathway

   This article has 6 authors:

   1. Yiting Deng
   2. Yuanhang He
   3. Juan Xu
   4. Haoting He
   5. Manling Zhang
   6. Guang Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides abundant valuable scRNA-Seq data that profiles fibroblasts involved in myocardium and coronary vasculature development. However, the evidence supporting the authors' claims is currently incomplete. The inclusion of additional citations, more in-depth discussions, and further analyses or experiments to validate the scRNA-Seq data would have significantly strengthened the study. Nonetheless, the scRNA-Seq expression data will be a resource that is of value to researchers in the field.

   Reviewed by eLife

6. Repeated activation of preoptic area-recipient neurons in posterior paraventricular nucleus mediates chronic heat-induced negative emotional valence and hyperarousal states

   This article has 3 authors:

   1. Zhiping Cao
   2. Wing-Ho Yung
   3. Ya Ke

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study aimed to identify how chronic heat exposure affects subsequent behavior and brain function. This work positively expands the field of thermoregulation. The data were collected using a myriad of next-generation approaches, including extensive behavior testing, thermal monitoring, electrophysiology, circuit mapping, and manipulations. As a result the strength of evidence is mostly solid, however a few weaknesses drove the some of the conclusions to be incompletely supported. These largely circle around the question of how unique these effects are to thermal stress (as opposed to other forms of stress), a lack of statistical analyses and rigor in some of the experiments and figures, and the specificity of the POA-pPVT pathway compared to other inputs to the PVT in the control of observed effects.

   Reviewed by eLife

7. Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part II: Physiology and Experimentation

   This article has 42 authors:

   1. James B Isbister
   2. András Ecker
   3. Christoph Pokorny
   4. Sirio Bolaños-Puchet
   5. Daniela Egas Santander
   6. Alexis Arnaudon
   7. Omar Awile
   8. Natali Barros-Zulaica
   9. Jorge Blanco Alonso
   10. Elvis Boci
   11. Giuseppe Chindemi
   12. Jean-Denis Courcol
   13. Tanguy Damart
   14. Thomas Delemontex
   15. Alexander Dietz
   16. Gianluca Ficarelli
   17. Mike Gevaert
   18. Joni Herttuainen
   19. Genrich Ivaska
   20. Weina Ji
   21. Daniel Keller
   22. James King
   23. Pramod Kumbhar
   24. Samuel Lapere
   25. Polina Litvak
   26. Darshan Mandge
   27. Eilif B Muller
   28. Fernando Pereira
   29. Judit Planas
   30. Rajnish Ranjan
   31. Maria Reva
   32. Armando Romani
   33. Christian Rössert
   34. Felix Schürmann
   35. Vishal Sood
   36. Aleksandra Teska
   37. Anil Tuncel
   38. Werner Van Geit
   39. Matthias Wolf
   40. Henry Markram
   41. Srikanth Ramaswamy
   42. Michael W Reimann

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable manuscript reports a large-scale, data-driven, biophysically detailed model of the non-barrel primary somatosensory cortex and generates numerous predictions that can further our understanding of how the multiscale organization of the cortex shapes neural activity. While the approach is solid, many of the findings are obtained using a much smaller portion of the model, which, together with the broad scope of the work, makes the narrative somewhat confusing and the strength of findings not entirely clear.

   Reviewed by eLife

8. Assemblies, synapse clustering and network topology interact with plasticity to explain structure-function relationships of the cortical connectome

   This article has 13 authors:

   1. András Ecker
   2. Daniela Egas Santander
   3. Marwan Abdellah
   4. Jorge Blanco Alonso
   5. Sirio Bolaños-Puchet
   6. Giuseppe Chindemi
   7. Dhuruva Priyan Gowri Mariyappan
   8. James B Isbister
   9. James Gonzalo King
   10. Pramod Kumbhar
   11. Ioannis Magkanaris
   12. Eilif B Muller
   13. Michael W Reimann

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study presents a biologically realistic, large-scale cortical model of the rat's non-barrel somatosensory cortex, investigating synaptic plasticity of excitatory connections under varying patterns of external activations and characterizing relations between network architecture and plasticity outcomes. While the model demonstrates several interesting phenomena, the results are less explanatory of causal relationships and more observational in nature; hence the evidence supporting the main conclusions remains incomplete.

   Reviewed by eLife

9. Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury

   This article has 11 authors:

   1. Tony Marchand
   2. Kemi E Akinnola
   3. Shoichiro Takeishi
   4. Maria Maryanovich
   5. Sandra Pinho
   6. Julien Saint-Vanne
   7. Alexander Birbrair
   8. Thierry Lamy
   9. Karin Tarte
   10. Paul S Frenette
   11. Kira Gritsman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study is valuable to the field, introducing a new model to test BM-periosteal stem cell function in vivo. The authors' findings suggested that periosteal stem cells are linked to hematopoietic regeneration. More comparisons with the conventional model and direct examination of periosteal stem cell factors in hematopoietic regeneration are missing. The observations are solid, however, the limitations in their experimental model made the overall impact incomplete; there is potential for improvements to be made in this area.

   Reviewed by eLife

10. Expanding the toolbox: Novel class IIb microcins show activity against Gram-negative ESKAPE and plant pathogens

    This article has 3 authors:

    1. Benedikt M Mortzfeld
    2. Shakti K Bhattarai
    3. Vanni Bucci

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study presents important advances in the discovery and assessment of microcins that improve our understanding of their prevalence and roles. The bioinformatics analysis, expression, and antimicrobial assays are solid, although the diverging evaluations also indicated the need for additional support regarding the sequence analysis and validation to fully back some of the claims and conclusions. This study will appeal to researchers working on the discovery and analysis of novel peptide natural products.

    Reviewed by eLife