Latest preprint reviews

  1. Sp Transcription Factors Establish the Signaling Environment in the Neuromesodermal Progenitor Niche During Axial Elongation

    This article has 11 authors:
    1. Ravindra B Chalamalasetty
    2. Haley Tran
    3. Ryan Kelly
    4. Samuel Kuo
    5. Mark W Kennedy
    6. Moonsup Lee
    7. Sara Thomas
    8. Nikolaos Mandalos
    9. Vishal Koparde
    10. Francisco Pereira Lobo
    11. Terry P Yamaguchi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This fundamental work advances our understanding of how SP5 and SP8 promote neuromesodermal competent progenitors in murine embryos. Generally the evidence is compelling, with strong developmental genetics, transcriptomic, and genomic transcription binding surveys contributing to the strength of the data. Some of the language could be softened to avoid overinterpretation of the data, and figures and diagrams could be improved.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Criticality-driven enhancer-promoter dynamics in Drosophila chromosomes

    This article has 4 authors:
    1. Gautham Ganesh
    2. Jean-Bernard Fiche
    3. Marcelo Nöllmann
    4. Julien Mozziconacci
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript uses modeling approaches to provide mechanistic insight into the structural and dynamic properties of enhancer-promoter interactions in Drosophila. Given the interest in this field, this is a timely approach, and the results give useful insights by providing predictions about the processivity of cohesin loop extrusion in Drosophila and concluding that the compartmental interaction strength is poised near criticality in the coil-globule phase space. The evidence provided to support some of the conclusions is, however, incomplete and would be strengthened by better considering some of the caveats in the data used to constrain the models, such as the use of "homie" genetic elements in the dynamic data. There is insufficient evidence provided for the dynamics being criticality-driven, and in addition, consideration of alternative models would further strengthen the conclusions of the manuscript.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. RubyACRs Enable Red-Shifted Optogenetic Inhibition in Freely Behaving Drosophila

    This article has 9 authors:
    1. Daniel Bushey
    2. Hiroshi Shiozaki
    3. Yichun Shuai
    4. Jihong Zheng
    5. Vivek Jayaraman
    6. Jeremy P Hasseman
    7. Ilya Kolb
    8. GENIE Project Team
    9. Glenn C Turner
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work describes the adaptation and evaluation of two red-shifted anion channelrhodopsins (RubyACRs) for optogenetic inhibition in Drosophila. The study provides convincing evidence for the effectiveness of RubyACRs in fly neurons, including electrophysiology, calcium imaging, and behavioral analysis. With minor revisions to address potential toxicity and compatibility with 2-photon imaging, this paper and the publicly available fly lines it describes will be resources that are of value to the neuroscience community.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
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