Latest preprint reviews

1. Optogenetic control of the Bicoid morphogen reveals fast and slow modes of gap gene regulation

   This article has 8 authors:

   1. Anand P. Singh
   2. Ping Wu
   3. Sergey Ryabichko
   4. João Raimundo
   5. Michael Swan
   6. Eric Wieschaus
   7. Thomas Gregor
   8. Jared E. Toettcher

   Reviewed by ASAPbio crowd review

2. Nuclear tension controls mitotic entry by regulating cyclin B1 nuclear translocation

   This article has 5 authors:

   1. Margarida Dantas
   2. Andreia Oliveira
   3. Paulo Aguiar
   4. Helder Maiato
   5. Jorge G. Ferreira

   Reviewed by Review Commons, ASAPbio crowd review

3. Optogenetic control of NOTCH1 signaling

   This article has 7 authors:

   1. Joanna Kałafut
   2. Jakub Czapiński
   3. Alicja Przybyszewska-Podstawka
   4. Arkadiusz Czerwonka
   5. Adrian Odrzywolski
   6. Cecilia Sahlgren
   7. Adolfo Rivero-Müller

   Reviewed by ASAPbio crowd review

4. Exploring functional protein covariation across single cells using nPOP

   This article has 5 authors:

   1. Andrew Leduc
   2. R. Gray Huffman
   3. Joshua Cantlon
   4. Saad Khan
   5. Nikolai Slavov

   Reviewed by ASAPbio crowd review

5. Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation

   This article has 8 authors:

   1. Alex F Thompson
   2. Patrick R Blackburn
   3. Noah S Arons
   4. Sarah N Stevens
   5. Dusica Babovic-Vuksanovic
   6. Jane B Lian
   7. Eric W Klee
   8. Jason Stumpff

   Reviewed by ASAPbio crowd review

6. mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes

   This article has 14 authors:

   1. Kun Leng
   2. Brendan Rooney
   3. Frank McCarthy
   4. Wenlong Xia
   5. Indigo V.L. Rose
   6. Sophie Bax
   7. Marcus Chin
   8. Saeed Fathi
   9. Kari A. Herrington
   10. Manuel Leonetti
   11. Aimee Kao
   12. Stephen P.J. Fancy
   13. Joshua E. Elias
   14. Martin Kampmann

   Reviewed by ASAPbio crowd review

7. Visualizing molecules of functional human profilin

   This article has 6 authors:

   1. Morgan L Pimm
   2. Xinbei Liu
   3. Farzana Tuli
   4. Jennifer Heritz
   5. Ashley Lojko
   6. Jessica L Henty-Ridilla

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper will be of interest to a broad audience of cell biologists and biochemists who study the cytoskeleton. It reports the development and rigorous characterization of a fully functional, fluorescently labeled version of profilin that can be used to visualize profilin's dynamic interactions in live cells. Owing to profilin's dual functions in regulating actin and microtubule assembly, this technological development will be a useful tool for a wide range of studies aimed at understanding the role of the cytoskeleton in driving fundamental cellular processes.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife, ASAPbio crowd review

8. Local regulation of extracellular vesicle traffic by the synaptic endocytic machinery

   This article has 10 authors:

   1. Cassandra R. Blanchette
   2. Amy L. Scalera
   3. Kathryn P. Harris
   4. Zechuan Zhao
   5. Erica C. Dresselhaus
   6. Kate Koles
   7. Anna Yeh
   8. Julia K. Apiki
   9. Bryan A. Stewart
   10. Avital A. Rodal

   Reviewed by ASAPbio crowd review

9. Quantitative analysis of nuclear pore complex organization in Schizosaccharomyces pombe

   This article has 5 authors:

   1. Joseph M Varberg
   2. Jay R Unruh
   3. Andrew J Bestul
   4. Azqa A Khan
   5. Sue L Jaspersen

   Reviewed by ASAPbio crowd review

10. Microtubule rescue at midzone edges promotes overlap stability and prevents spindle collapse during anaphase B

    This article has 3 authors:

    1. Manuel Lera-Ramirez
    2. François J Nédélec
    3. Phong T Tran

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This study carefully quantifies microtubule dynamics during anaphase in the fission yeast S. pombe. The high quality data revealed two new observations: that microtubule rescue occurs preferentially at the edge of the midzone and that microtubule growth speed decreases when the nuclear membrane wraps around the spindle midzone in late anaphase. This sheds new light on the interplay between the nuclear membrane and the midspindle in closed mitosis, and the study will be of interest to cell biologists studying spindle dynamics and mitosis.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by ASAPbio crowd review, eLife