Systems Biology

Hormone circuit explains why most HPA drugs fail for mood disorders and predicts the few that work

1. Tomer Milo
2. Shiraz Nir Halber
3. Moriya Raz
4. Dor Danan
5. Avi Mayo
6. Uri Alon

Reviewed by Review Commons

Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progression

1. Nadine Tuechler
2. Mira Lea Burtscher
3. Martin Garrido-Rodriguez
4. Muzamil Majid Khan
5. Dénes Türei
6. Christian Tischer
7. Sarah Kaspar
8. Jennifer Jasmin Schwarz
9. Frank Stein
10. Mandy Rettel
11. Rafael Kramann
12. Mikhail M Savitski
13. Julio Saez-Rodriguez
14. Rainer Pepperkok

Reviewed by Review Commons

Evaluating Study Design Rigor in Preclinical Cardiovascular Research: A Replication Study

1. Isaiah C Jimenez
2. Gabrielle C Montenegro
3. Keyana Zahiri
4. Damini Patel
5. Adrienne Mueller

• Curated by eLife

  eLife Assessment

  The objective of this important study is to assess the study design and rigor, enhance the quality of clinical research studies, and emphasize crucial design elements in basic science research. It specifically tackles the ongoing problem of experimental design deficiencies that obstruct the effective translation of research findings into clinical applications. This paper is particularly convincing as it highlights the lack of progress in addressing these issues over the past decade, despite a substantial body of existing research. It serves as a strong call to action for the broader scientific community to improve research practices.

Reviewed by eLife

Abundant clock proteins point to missing molecular regulation in the plant circadian clock

1. Uriel Urquiza-García
2. Nacho Molina
3. Karen J Halliday
4. Andrew J Millar

Reviewed by Review Commons