Systems Biology

Genome-wide conditional degron libraries for functional genomics

1. Eduardo Gameiro
2. Karla A. Juárez-Núñez
3. Jia Jun Fung
4. Susmitha Shankar
5. Brian Luke
6. Anton Khmelinskii

Reviewed by Review Commons

Unveiling Gene Perturbation Effects through Gene Regulatory Networks Inference from single-cell transcriptomic data

1. Clelia Corridori
2. Merrit Romeike
3. Giorgio Nicoletti
4. Christa Buecker
5. Samir Suweis
6. Sandro Azaele
7. Graziano Martello

Reviewed by Review Commons

Inference of gene regulatory networks for overcoming low performance in real-world data

1. Yusuke Hiki
2. Yuta Tokuoka
3. Takahiro G. Yamada
4. Akira Funahashi

Reviewed by Arcadia Science

Slowest possible replicative life at frigid temperatures for yeast

1. Diederik S. Laman Trip
2. Théo Maire
3. Hyun Youk

Reviewed by Arcadia Science

Systems analysis of miR-199a/b-5p and multiple miR-199a/b-5p targets during chondrogenesis

1. Krutik Patel
2. Matt Barter
3. Jamie Soul
4. Peter Clark
5. Carole Proctor
6. Ian Clark
7. David Young
8. Daryl P Shanley

• Curated by eLife

  eLife assessment

  This study provides valuable insight into the role of miR-199a/b-5p in cartilage formation. The evidence supporting the significance of the identified miRNA and its target mRNA transcripts is convincing. This paper will likely primarily benefit scientists focused on diseases related to this biological process, such as osteoarthritis. Furthermore, researchers with a broader interest in miRNAs may find the computational model to identify novel RNA-RNA interactions particularly helpful.

Reviewed by eLife

Delineating markers of disease-disease interaction: a systematic methodology and its application to multiple diabetes-helminth cohorts

1. Nilesh Anantha Subramanian
2. Philge Philip
3. Anuradha Rajamanickam
4. Nathella Pavan Kumar
5. Subash Babu
6. Manikandan Narayanan

Reviewed by Arcadia Science

Sfp1 integrates TORC1 and PKA activity towards yeast ribosome biogenesis

1. Luc-Alban Vuillemenot
2. Franz Y. Ho
3. Andreas Milias-Argeitis

Reviewed by Review Commons

Interpreting roles of mutations associated with the emergence of S. aureus USA300 strains using transcriptional regulatory network reconstruction

1. Saugat Poudel
2. Jason Hyun
3. Ying Hefner
4. Jon Monk
5. Victor Nizet
6. Bernhard O Palsson

• Curated by eLife

  eLife assessment

  This study presents valuable findings on core genome mutations that might have driven the emergence of the Staphylococcus aureus lineage USA300, a frequent cause of community-acquired infections. The authors present a solid novel approach that combines genome-wide association studies and RNA-expression analyses, both applied to extensive publicly available datasets. This approach generated an intriguing hypothesis that should be validated experimentally. The work will interest microbiologists working in genomic epidemiology and phenotype-genotype association studies.

Reviewed by eLife

Dynamic map illuminates Hippo to cMyc module crosstalk driving cardiomyocyte proliferation

1. Bryana N. Harris
2. Laura A. Woo
3. R. Noah Perry
4. Mete Civelek
5. Matthew J. Wolf
6. Jeffrey J. Saucerman

Reviewed by Review Commons

Mining the heparinome for cryptic antimicrobial peptides that selectively kill gram-negative bacteria

1. Daniel Sandín
2. Javier Valle
3. Jordi Gómez
4. Laura Comas
5. María Nieves Larrosa
6. Juan José González-López
7. María Ángeles Jiménez
8. David Andreu
9. Marc Torrent

Reviewed by Review Commons