1. An interactome landscape of SARS-CoV-2 virus-human protein-protein interactions by protein sequence-based multi-label classifiers

    This article has 1 author:
    1. Ho-Joon Lee

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    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  2. Multisensory-motor integration in olfactory navigation of silkmoth, Bombyx mori, using virtual reality system

    This article has 5 authors:
    1. Mayu Yamada
    2. Hirono Ohashi
    3. Koh Hosoda
    4. Daisuke Kurabayashi
    5. Shunsuke Shigaki
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This paper uses a multi-model virtual reality system to assess which combinations of visual, wind, and olfactory information male silk moths rely on to find a female. The overall conclusion is that for the moths to search effectively, wind direction information is an important input. Vision, on the other hand, while it is used to control angular velocity, does not appear to be important for the moths to search effectively. This paper is of interest to neuroscientists and engineers interested in how multimodal sensory input controls navigational behavior. The experiments and modeling effort provide an advance in our understanding of how odor and wind information are combined in male silkmoths as they search for females.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. High-resolution mapping of the period landscape reveals polymorphism in cell cycle frequency tuning

    This article has 6 authors:
    1. Zhengda Li
    2. Shiyuan Wang
    3. Meng Sun
    4. Minjun Jin
    5. Daniel Khain
    6. Qiong Yang
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This paper uses microfluidics and Xenopus extracts to investigate the effects of mitotic feedbacks on the cell cycle period. It is shown that the inhibition of G2 regulatory positive feedback loops does not reduce the tunability of the cell cycle oscillations, while interference with PP2A phosphatase can completely block of the cell cycle. The experiments are well-conducted and the results should be of interest to researchers interested in the cell cycle, specifically in the regulation of mitosis.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife

    This article has 4 evaluationsAppears in 2 listsLatest version Latest activity
  4. A unified framework for measuring selection on cellular lineages and traits

    This article has 5 authors:
    1. Shunpei Yamauchi
    2. Takashi Nozoe
    3. Reiko Okura
    4. Edo Kussell
    5. Yuichi Wakamoto
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      The manuscript by Wakamoto and colleagues presents a general statistical framework to infer selection on a quantitative trait based on measurements of the values of this trait along related cell lineages. The manuscript provides both a detailed explanation of the mathematical underpinnings of the method and an illustration of its application to existing and new cell lineage datasets. The framework is widely applicable to general exponentially growing populations and is not tailored to particular growth models or environmental conditions.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  5. Mutational Signatures as Sensors of Environmental Exposures: Role of Smoking in COVID-19 Vulnerabilities

    This article has 6 authors:
    1. Yoo-Ah Kim
    2. Ermin Hodzic
    3. Ariella Saslafsky
    4. Damian Wojtowicz
    5. Bayarbaatar Amgalan
    6. Teresa M. Przytycka

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    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  6. LIGHTHOUSE illuminates therapeutics for a variety of diseases including COVID-19

    This article has 8 authors:
    1. Hideyuki Shimizu
    2. Manabu Kodama
    3. Masaki Matsumoto
    4. Yasuko Orba
    5. Michihito Sasaki
    6. Akihiko Sato
    7. Hirofumi Sawa
    8. Keiichi I. Nakayama

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    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  7. Deciphering the role of the Pancreatic Secretome in Covid-19 associated Multi-Organ Dysfunctions

    This article has 2 authors:
    1. Ekta Pathak
    2. Rajeev Mishra

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    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  8. Gene networks under circadian control exhibit diurnal organization in primate organs

    This article has 4 authors:
    1. Jie Li
    2. Pengxing Nie
    3. Christoph W. Turck
    4. Guang-Zhong Wang

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  9. Protein allocation and utilization in the versatile chemolithoautotroph Cupriavidus necator

    This article has 10 authors:
    1. Michael Jahn
    2. Nick Crang
    3. Markus Janasch
    4. Andreas Hober
    5. Björn Forsström
    6. Kyle Kimler
    7. Alexander Mattausch
    8. Qi Chen
    9. Johannes Asplund-Samuelsson
    10. Elton Paul Hudson
    This article has been curated by 1 group:
    • Curated by eLife

      Evaluation Summary:

      This work combines elegant experimental approaches with modelling predictions to study of metabolic adaptations in the bacterium Cupriavidus necator, a microorganism of interest given its metabolic versatility and potential industrial applications. This manuscript will be interesting for microbiologists and systems biologists who want to understand how protein production and economy and enzyme utilization differs in a versatile microorganism in different conditions.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  10. Synthetic lethality-based prediction of anti-SARS-CoV-2 targets

    This article has 12 authors:
    1. Lipika R. Pal
    2. Kuoyuan Cheng
    3. Nishanth Ulhas Nair
    4. Laura Martin-Sancho
    5. Sanju Sinha
    6. Yuan Pu
    7. Laura Riva
    8. Xin Yin
    9. Fiorella Schischlik
    10. Joo Sang Lee
    11. Sumit K. Chanda
    12. Eytan Ruppin

    Reviewed by ScreenIT

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
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