1. Systems analysis of miR-199a/b-5p and multiple miR-199a/b-5p targets during chondrogenesis

    This article has 8 authors:
    1. K Patel
    2. MJ Barter
    3. J Soul
    4. P Clark
    5. CJ Proctor
    6. IM Clark
    7. DA Young
    8. DP Shanley
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides valuable insight into the role of miR-199a/b-5p in cartilage formation. The evidence supporting the significance of the identified miRNA and its target mRNA transcripts is convincing. This paper will likely primarily benefit scientists focused on diseases related to this biological process, such as osteoarthritis. Furthermore, researchers with a broader interest in miRNAs may find the computational model to identify novel RNA-RNA interactions particularly helpful.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  2. Systems analysis of multiple diabetes-helminth cohorts reveals markers of disease-disease interaction

    This article has 6 authors:
    1. Nilesh Subramanian
    2. Philge Philip
    3. Anuradha Rajamanickam
    4. Nathella Pavan Kumar
    5. Subash Babu
    6. Manikandan Narayanan

    Reviewed by Arcadia Science

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  3. Sfp1 integrates TORC1 and PKA activity towards yeast ribosome biogenesis

    This article has 3 authors:
    1. Luc-Alban Vuillemenot
    2. Franz Y. Ho
    3. Andreas Milias-Argeitis

    Reviewed by Review Commons

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  4. Interpreting roles of mutations associated with the emergence of S. aureus USA300 strains using transcriptional regulatory network reconstruction

    This article has 6 authors:
    1. Saugat Poudel
    2. Jason Hyun
    3. Ying Hefner
    4. Jon Monk
    5. Victor Nizet
    6. Bernhard O Palsson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents valuable findings on core genome mutations that might have driven the emergence of the Staphylococcus aureus lineage USA300, a frequent cause of community-acquired infections. The authors present a solid novel approach that combines genome-wide association studies and RNA-expression analyses, both applied to extensive publicly available datasets. This approach generated an intriguing hypothesis that should be validated experimentally. The work will interest microbiologists working in genomic epidemiology and phenotype-genotype association studies.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  5. Perturbation-response analysis of in silico metabolic dynamics in nonlinear regime: Hard-coded responsiveness in the cofactors and network sparsity

    This article has 2 authors:
    1. Yusuke Himeoka
    2. Chikara Furusawa
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study uses dynamic metabolic models to compare perturbation responses in a bacterial system, analyzing whether they return to their steady state or amplify beyond the initial perturbation. The evidence supporting the emergent properties of perturbed metabolic systems to network topology and sensitivity to specific metabolites is compelling. However, the mathematical explanation of the perturbation response is incomplete, and a more comprehensive metabolic and biosynthesis model would be beneficial.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  6. Dynamic map illuminates Hippo to cMyc module crosstalk driving cardiomyocyte proliferation

    This article has 6 authors:
    1. Bryana N. Harris
    2. Laura A. Woo
    3. R. Noah Perry
    4. Mete Civelek
    5. Matthew J. Wolf
    6. Jeffrey J. Saucerman

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Mining the heparinome for cryptic antimicrobial peptides that selectively kill gram-negative bacteria

    This article has 9 authors:
    1. Daniel Sandín
    2. Javier Valle
    3. Jordi Gómez
    4. Laura Comas
    5. María Nieves Larrosa
    6. Juan José González-López
    7. María Ángeles Jiménez
    8. David Andreu
    9. Marc Torrent

    Reviewed by Review Commons

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  8. Diurnal rhythmicity in metabolism and salivary effector expression shapes host colonization by aphids

    This article has 6 authors:
    1. Jinlong Han
    2. Daniel Kunk
    3. Meihua Cui
    4. Yoshiahu Goldstein
    5. Vered Tzin
    6. Vamsi J. Nalam
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this study, the authors found that a species of aphid that is a known agricultural pest salivated longer and produced more honeydew when feeding at night. The authors identified aphid genes with diurnal expression patterns, including potential saliva-related genes. Silencing these genes reduced aphid performance only on real plants, suggesting a specific role in plant feeding. While this study is valuable for understanding plant-insect interactions in agriculture, it is currently incomplete, as further research is needed to elucidate the function of the identified genes.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  9. Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age

    This article has 4 authors:
    1. Dylan C. Sarver
    2. Muzna Saqib
    3. Fangluo Chen
    4. G. William Wong
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The authors present an important resource to quantify mitochondrial function across many organs in mice. The convincing conclusions are supported by the identification of processes that specifically differ between young and old, or between male and female mice. All reviewers point to the merit of this study in providing a comprehensive resource to contextualize mitochondrial functions across the body. Some further suggestions are made to clarify conclusions in terms of data normalization, interpretations of comparative analyses between organs.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. Self-inhibiting percolation and viral spreading in epithelial tissue

    This article has 3 authors:
    1. Xiaochan Xu
    2. Bjarke Frost Nielsen
    3. Kim Sneppen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a cellular automaton model to study the dynamics of virus-induced signalling and innate host defense against viruses such as SARS-CoV-2 in epithelial tissue. The simulations and data analysis are convincing and represent a valuable contribution that would be of interest to researchers studying the dynamics of viral propagation.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity