Physiology

Exercise-Induced Hypoalgesia Following High- vs. Low-Intensity Aerobic Exercise in Fit Females

1. Janne I Nold
2. Tahmine Fadai
3. Zora P Gerbers
4. Christian Büchel

• Curated by eLife

  eLife Assessment

  This study proposes that fitness level influences exercise-induced hypoalgesia in women. However, the evidence to support this claim is incomplete: the conclusions rely on a small interaction that emerges only under specific conditions and are incongruent with the title, the findings are inconsistent across pain modalities and stimulus intensities, the analysis approach does not fully exploit the continuous pain ratings collected, and the absence of a baseline condition limits the interpretability of results as reflecting true hypoalgesia. Additionally, the methods by which fitness level was categorized across cohorts can be questioned, and the results and figures do not clearly illustrate how between-group comparisons were conducted. With a proper revision, it could be useful for sports medicine practitioners to consider how they administer exercise protocols to help those experiencing pain.

Reviewed by eLife

Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline

1. Sara C Sebag
2. Tate Neff
3. Qingwen Qian
4. Arvand Asghari
5. Zhuozhi Wang
6. Zeyuan Zhang
7. Mark Li
8. Meihua Hao
9. Vitor A Lira
10. Hongli Sun
11. Matthew J Potthoff
12. Ling Yang

• Curated by eLife

  eLife Assessment

  This valuable study identifies a brown adipose tissue-specific heat shock factor 1 (HSF1)-alcohol dehydrogenase 5 (ADH5) axis that regulates oxidative stress and cellular senescence during aging. The authors show that ADH5 deficiency drives BAT dysfunction and contributes to organismal health decline in aged mice. The evidence is convincing, and the work will be of broad interest to the adipose tissue and aging research communities.

Reviewed by eLife

Cytokine control of systemic hypoxia tolerance in Drosophila

1. Kate Ding
2. Prajakta Bodkhe
3. Byoungchun Lee
4. Danielle Polan
5. Amy Wycislik
6. Tiffany Cheung
7. Sophie Wu
8. Savraj S Grewal

Reviewed by Review Commons, PREreview

Metabolism fine tuning and cardiokines secretion represent adaptative responses of the heart to High Fat and High Sugar Diets in flies

1. Lucie Khamvongsa-Charbonnier
2. Laurent Kremmer
3. Magali Torres
4. Sallouha Krifa
5. Charis Aubert
6. Alice Corbet
7. Loïc Crespo
8. Laurence Röder
9. Laurent Perrin
10. Nathalie Arquier

Reviewed by Review Commons

The Hypothalamic–Pituitary–Adrenal Axis Orchestrates Energy Homeostasis during Cold Exposure

1. Mireia Llerins Perez
2. Xinran Gao
3. Laura Heimerl
4. Yuanyuan Wang
5. Katharina Schnabl
6. Uwe Firzlaff
7. Harald Luksch
8. Martin Klingenspor
9. Nina Henriette Uhlenhaut
10. Dehua Wang
11. Yongguo Li

Reviewed by PREreview