1. A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria

    This article has 9 authors:
    1. Tumininu S Faniyan
    2. Xinyi Zhang
    3. Donald A Morgan
    4. Jorge Robles
    5. Siresha Bathina
    6. Paul S Brookes
    7. Kamal Rahmouni
    8. Rachel J Perry
    9. Kavaljit H Chhabra
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The study presents valuable findings on compensatory mechanisms in response to glycosuria. The evidence supporting the claims is solid, although a causal relationship is somewhat uncertain and the addition of a more clinically relevant model would have strengthened the findings. The work will be of interest to diabetes investigators.

    Reviewed by eLife, PREreview

    This article has 12 evaluationsAppears in 3 listsLatest version Latest activity
  2. An acute microglial metabolic response controls metabolism and improves memory

    This article has 20 authors:
    1. Anne Drougard
    2. Eric H Ma
    3. Vanessa Wegert
    4. Ryan Sheldon
    5. Ilaria Panzeri
    6. Naman Vatsa
    7. Stefanos Apostle
    8. Luca Fagnocchi
    9. Judith Schaf
    10. Klaus Gossens
    11. Josephine Völker
    12. Shengru Pang
    13. Anna Bremser
    14. Erez Dror
    15. Francesca Giacona
    16. Sagar
    17. Michael X Henderson
    18. Marco Prinz
    19. Russell G Jones
    20. J. Andrew Pospisilik
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study demonstrates a link between an acute high fat diet, microglial metabolism and improved higher cognitive function. The evidence supporting the proposed mechanism in vivo is incomplete at this stage due to non-trivial technical limitations but the authors provide convincing in vitro metabolic characterization of primary microglia cultures to support the model. This work will be of interest to a broad audience in the field of neuroscience, metabolism, and immunology.

    Reviewed by eLife

    This article has 14 evaluationsAppears in 1 listLatest version Latest activity
  3. The Kv2.2 channel mediates the inhibition of Prostaglandin E2 on glucose-stimulated insulin secretion in pancreatic β-cells

    This article has 12 authors:
    1. Chengfang Pan
    2. Ying Liu
    3. Liangya Wang
    4. Wengyong Fan
    5. Yunzhi Ni
    6. Xuefeng Zhang
    7. Di Wu
    8. Chenyang Li
    9. Jin Li
    10. Zhaoyang Li
    11. Rui Liu
    12. Changlong Hu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The study presents valuable findings on the molecular mechanisms of glucose-stimulated insulin secretion from pancreatic islets, focusing on the main regulatory elements of the signaling pathway in physiological conditions. While the evidence supporting the conclusions is solid, the study can be strengthened by the use of a beta cell line or knockout mice. The work will be of interest to cell biologists and biochemists working on diabetes.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

    This article has 15 authors:
    1. Yanling Huang
    2. Haocong Mo
    3. Jie Yang
    4. Luyang Gao
    5. Tian Tao
    6. Qing Shu
    7. Wenying Guo
    8. Yawen Zhao
    9. Jingya Lyu
    10. Qimeng Wang
    11. Jinghui Guo
    12. Hening Zhai
    13. Linyan Zhu
    14. Hui Chen
    15. Geyang Xu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study focuses on the regulation of GLP-1 in enteroendocrine L cells and how this may be stimulated by the mechanogated ion channel Piezo1. The work is innovative and the hypothesis that is being tested may have important mechanistic and translational implications. The data remains incomplete at present and needs a substantial amount of supporting evidence and corrections to be a stronger manuscript and publication.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. Cytosolic S100A8/A9 promotes Ca2+ supply at LFA-1 adhesion clusters during neutrophil recruitment

    This article has 16 authors:
    1. Matteo Napoli
    2. Roland Immler
    3. Ina Rohwedder
    4. Valerio Lupperger
    5. Johannes Pfabe
    6. Mariano Gonzalez Pisfil
    7. Anna Yevtushenko
    8. Thomas Vogl
    9. Johannes Roth
    10. Melanie Salvermoser
    11. Steffen Dietzel
    12. Marjan Slak Rupnik
    13. Carsten Marr
    14. Barbara Walzog
    15. Markus Sperandio
    16. Monika Pruenster
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment:

      This important study investigates the contribution of cytosolic S100A/8 to neutrophil migration to inflamed tissues. The authors provide convincing evidence for how the loss of cytosolic S100A/8 specifically affects the ability of neutrophils to crawl and subsequently adhere under shear stress. This study will be of interest in fields where inflammation is implicated, such as autoimmunity or sepsis.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  6. SLC35G1: A highly chloride-sensitive transporter responsible for the basolateral membrane transport in intestinal citrate absorption

    This article has 10 authors:
    1. Yoshihisa Mimura
    2. Tomoya Yasujima
    3. Katsuhisa Inoue
    4. Shogo Akino
    5. Chitaka Namba
    6. Hiroyuki Kusuhara
    7. Yutaro Sekiguchi
    8. Kinya Ohta
    9. Takahiro Yamashiro
    10. Hiroaki Yuasa
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This work identifies the molecular function of an orphan human transporter, SLC35G1, providing convincing but somewhat incomplete evidence that this protein is involved in intestinal citrate absorption. This work provides important insight into transporter function and human physiology.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Genetic code expansion, click chemistry, and light-activated PI3K reveal details of membrane protein trafficking downstream of receptor tyrosine kinases

    This article has 12 authors:
    1. Duk-Su Koh
    2. Anastasiia Stratiievska
    3. Subhashis Jana
    4. Shauna C. Otto
    5. Teresa M. Swanson
    6. Anthony Nhim
    7. Sara Carlson
    8. Marium Raza
    9. Lígia Araujo Naves
    10. Eric N. Senning
    11. Ryan Mehl
    12. Sharona E. Gordon
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study develops a new and important method for dissecting out two overlapping cell signaling pathways, phosphoinositide signaling and membrane protein trafficking. The combination of two state-of-the-art spectroscopic techniques provides compelling evidence for a reciprocal influence between an enzyme and a channel. The work will be of interest to the broader cell biology, biophysics and biochemistry communities.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  8. Reliance on self-reports and estimated food composition data in nutrition research introduces significant bias that can only be addressed with biomarkers

    This article has 4 authors:
    1. Javier I Ottaviani
    2. Virag Sagi-Kiss
    3. Hagen Schroeter
    4. Gunter GC Kuhnle
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study, using three bioactive compounds as a model, demonstrates that estimating the intake of food components based on food composition databases and self-reported dietary data is highly unreliable. The authors present convincing data showing the differences in the estimated quantile of intake of three bioactive compounds between biomarker and 24-hour dietary recall with food-composition database. The work will be of broad interest to the clinical nutrition research community.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  9. ATP and glutamate coordinate contractions in the freshwater sponge Ephydatia muelleri

    This article has 3 authors:
    1. Vanessa R Ho
    2. Greg G Goss
    3. Sally P Leys

    Reviewed by Arcadia Science

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  10. Neuroestrogens facilitate male-typical behaviors by potentiating androgen receptor signaling in medaka

    This article has 11 authors:
    1. Yuji Nishiike
    2. Shizuku Maki
    3. Daichi Miyazoe
    4. Kiyoshi Nakasone
    5. Yasuhiro Kamei
    6. Takeshi Todo
    7. Tomoko Ishikawa-Fujiwara
    8. Kaoru Ohno
    9. Takeshi Usami
    10. Yoshitaka Nagahama
    11. Kataaki Okubo
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The authors provide an important step forward in understanding how brain-derived hormones modulate behavior, using medaka fish as a model system. Knockout lines present convincing evidence from multiple mutant lines, showing that estrogens play a significant role in male social behavior, and that lacking aromatase changes brain gene expression. The conclusions for females are less substantiated, and the conclusions regarding sexual differentiation should be considered carefully.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity