Pharmacology and Toxicology

Favipiravir, umifenovir and camostat mesylate: a comparative study against SARS-CoV-2

1. Mehnmet Altay Unal
2. Omur Besbinar
3. Hasan Nazir
4. Gokce Yagmur Summak
5. Fatma Bayrakdar
6. Lucia Gemma Delogu
7. Tambay Taskin
8. Sibel Aysil Ozkan
9. Kamil Can Akcali
10. Acelya Yilmazer

Reviewed by ScreenIT

Effect of cannabidiol on apoptosis and cellular interferon and interferon-stimulated gene responses to the SARS-CoV-2 genes ORF8, ORF10 and M protein

1. Maria Fernanda Fernandes
2. John Zewen Chan
3. Chia Chun Joey Hung
4. Michelle Victoria Tomczewski
5. Robin Elaine Duncan

Reviewed by ScreenIT

Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels

1. Erika Cecon
2. Daniela Fernandois
3. Nicolas Renault
4. Caio Fernando Ferreira Coelho
5. Jan Wenzel
6. Corentin Bedart
7. Charlotte Izabelle
8. Sarah Gallet
9. Sophie Le Poder
10. Bernard Klonjkowski
11. Markus Schwaninger
12. Vincent Prevot
13. Julie Dam
14. Ralf Jockers

Reviewed by ScreenIT

Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants

1. Lianghui Zhang
2. Soumajit Dutta
3. Shiqin Xiong
4. Matthew Chan
5. Kui K. Chan
6. Timothy M. Fan
7. Keith L. Bailey
8. Matthew Lindeblad
9. Laura M. Cooper
10. Lijun Rong
11. Anthony F. Gugliuzza
12. Diwakar Shukla
13. Erik Procko
14. Jalees Rehman
15. Asrar B. Malik

Reviewed by ScreenIT

Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands

1. Aaron L Nichols
2. Zack Blumenfeld
3. Chengcheng Fan
4. Laura Luebbert
5. Annet EM Blom
6. Bruce N Cohen
7. Jonathan S Marvin
8. Philip M Borden
9. Charlene H Kim
10. Anand K Muthusamy
11. Amol V Shivange
12. Hailey J Knox
13. Hugo Rego Campello
14. Jonathan H Wang
15. Dennis A Dougherty
16. Loren L Looger
17. Timothy Gallagher
18. Douglas C Rees
19. Henry A Lester

• Curated by eLife

  Evaluation Summary:

  Nichols et al. developed and characterized the first fluorescent sensors for several nicotinic receptor partial agonists relevant to smoking cessation. It is potentially a major advance for the field. They leveraged crystallography to understand the mechanism by which the ligands enhance fluorescence, then characterized top sensors for sensitivity, selectivity, and kinetics, and their utility in plasma membrane and ER sensing in neurons and cell lines. The tools developed by this team will enable investigators to track nicotinic receptor partial agonists in different subcellular compartments with relatively fast time resolution.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife

Potential inhibitors for blocking the interaction of the coronavirus SARS-CoV-2 spike protein and its host cell receptor ACE2

1. Changzhi Li
2. Hongjuan Zhou
3. Lingling Guo
4. Dehuan Xie
5. Huiping He
6. Hong Zhang
7. Yixiu Liu
8. Lixia Peng
9. Lisheng Zheng
10. Wenhua Lu
11. Yan Mei
12. Zhijie Liu
13. Jie Huang
14. Mingdian Wang
15. Ditian Shu
16. Liuyan Ding
17. Yanhong Lang
18. Feifei Luo
19. Jing Wang
20. Bijun Huang
21. Peng Huang
22. Song Gao
23. Jindong Chen
24. Chao-Nan Qian

Reviewed by ScreenIT

The Petasites hybridus CO2 Extract (Ze 339) Blocks SARS-CoV-2 Replication In Vitro

1. Lorena Urda
2. Matthias Heinrich Kreuter
3. Jürgen Drewe
4. Georg Boonen
5. Veronika Butterweck
6. Thomas Klimkait

Reviewed by ScreenIT

Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy

1. Leying Chen
2. Qing You
3. Min Liu
4. Shuaihu Li
5. Zhaoyu Wu
6. Jiajun Hu
7. Yurui Ma
8. Liangyong Xia
9. Ying Zhou
10. Nan Xu
11. Shiyi Zhang

• Curated by eLife

  Evaluation Summary:

  This paper will be of interest to oncologists and dermatologists and has high clinical relevance. It reveals a novel mechanism of EGFR inhibitor-induced rash which be may closely related to atrophy of dermal white adipose tissue (dWAT). A series of experimental manipulations dissect the mechanism with a murine model, supporting the major claims of the paper.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Drug-Repurposing Screening Identified Tropifexor as a SARS-CoV-2 Papain-like Protease Inhibitor

1. Chunlong Ma
2. Yanmei Hu
3. Yuyin Wang
4. Juliana Choza
5. Jun Wang

Reviewed by ScreenIT

Atazanavir Is a Competitive Inhibitor of SARS-CoV-2 Mpro, Impairing Variants Replication In Vitro and In Vivo

1. Otávio Augusto Chaves
2. Carolina Q. Sacramento
3. André C. Ferreira
4. Mayara Mattos
5. Natalia Fintelman-Rodrigues
6. Jairo R. Temerozo
7. Leonardo Vazquez
8. Douglas Pereira Pinto
9. Gabriel P. E. da Silveira
10. Laís Bastos da Fonseca
11. Heliana Martins Pereira
12. Aluana Santana Carlos
13. Joana C. d’Avila
14. João P. B. Viola
15. Robson Q. Monteiro
16. Patrícia T. Bozza
17. Hugo Caire Castro-Faria-Neto
18. Thiago Moreno L. Souza

Reviewed by ScreenIT