Pharmacology and Toxicology

Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants

1. Lianghui Zhang
2. Soumajit Dutta
3. Shiqin Xiong
4. Matthew Chan
5. Kui K. Chan
6. Timothy M. Fan
7. Keith L. Bailey
8. Matthew Lindeblad
9. Laura M. Cooper
10. Lijun Rong
11. Anthony F. Gugliuzza
12. Diwakar Shukla
13. Erik Procko
14. Jalees Rehman
15. Asrar B. Malik

Reviewed by ScreenIT

Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands

1. Aaron L Nichols
2. Zack Blumenfeld
3. Chengcheng Fan
4. Laura Luebbert
5. Annet EM Blom
6. Bruce N Cohen
7. Jonathan S Marvin
8. Philip M Borden
9. Charlene H Kim
10. Anand K Muthusamy
11. Amol V Shivange
12. Hailey J Knox
13. Hugo Rego Campello
14. Jonathan H Wang
15. Dennis A Dougherty
16. Loren L Looger
17. Timothy Gallagher
18. Douglas C Rees
19. Henry A Lester

• Curated by eLife

  Evaluation Summary:

  Nichols et al. developed and characterized the first fluorescent sensors for several nicotinic receptor partial agonists relevant to smoking cessation. It is potentially a major advance for the field. They leveraged crystallography to understand the mechanism by which the ligands enhance fluorescence, then characterized top sensors for sensitivity, selectivity, and kinetics, and their utility in plasma membrane and ER sensing in neurons and cell lines. The tools developed by this team will enable investigators to track nicotinic receptor partial agonists in different subcellular compartments with relatively fast time resolution.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife

Potential inhibitors for blocking the interaction of the coronavirus SARS-CoV-2 spike protein and its host cell receptor ACE2

1. Changzhi Li
2. Hongjuan Zhou
3. Lingling Guo
4. Dehuan Xie
5. Huiping He
6. Hong Zhang
7. Yixiu Liu
8. Lixia Peng
9. Lisheng Zheng
10. Wenhua Lu
11. Yan Mei
12. Zhijie Liu
13. Jie Huang
14. Mingdian Wang
15. Ditian Shu
16. Liuyan Ding
17. Yanhong Lang
18. Feifei Luo
19. Jing Wang
20. Bijun Huang
21. Peng Huang
22. Song Gao
23. Jindong Chen
24. Chao-Nan Qian

Reviewed by ScreenIT

The Petasites hybridus CO2 Extract (Ze 339) Blocks SARS-CoV-2 Replication In Vitro

1. Lorena Urda
2. Matthias Heinrich Kreuter
3. Jürgen Drewe
4. Georg Boonen
5. Veronika Butterweck
6. Thomas Klimkait

Reviewed by ScreenIT

Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy

1. Leying Chen
2. Qing You
3. Min Liu
4. Shuaihu Li
5. Zhaoyu Wu
6. Jiajun Hu
7. Yurui Ma
8. Liangyong Xia
9. Ying Zhou
10. Nan Xu
11. Shiyi Zhang

• Curated by eLife

  Evaluation Summary:

  This paper will be of interest to oncologists and dermatologists and has high clinical relevance. It reveals a novel mechanism of EGFR inhibitor-induced rash which be may closely related to atrophy of dermal white adipose tissue (dWAT). A series of experimental manipulations dissect the mechanism with a murine model, supporting the major claims of the paper.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Drug-Repurposing Screening Identified Tropifexor as a SARS-CoV-2 Papain-like Protease Inhibitor

1. Chunlong Ma
2. Yanmei Hu
3. Yuyin Wang
4. Juliana Choza
5. Jun Wang

Reviewed by ScreenIT

Atazanavir Is a Competitive Inhibitor of SARS-CoV-2 Mpro, Impairing Variants Replication In Vitro and In Vivo

1. Otávio Augusto Chaves
2. Carolina Q. Sacramento
3. André C. Ferreira
4. Mayara Mattos
5. Natalia Fintelman-Rodrigues
6. Jairo R. Temerozo
7. Leonardo Vazquez
8. Douglas Pereira Pinto
9. Gabriel P. E. da Silveira
10. Laís Bastos da Fonseca
11. Heliana Martins Pereira
12. Aluana Santana Carlos
13. Joana C. d’Avila
14. João P. B. Viola
15. Robson Q. Monteiro
16. Patrícia T. Bozza
17. Hugo Caire Castro-Faria-Neto
18. Thiago Moreno L. Souza

Reviewed by ScreenIT

Hypertonic saline and aprotinin based blockage of SARS-CoV-2 specific furin site cleavage by inhibition of nasal protease activity

1. Clarissa Li
2. Adam W. Li

Reviewed by ScreenIT

Dual Effects of Nanoviricides Platform Technology Based NV-CoV-2 Biomimetic Polymer Against COVID-19

1. Anil Diwan
2. Ashok Chakraborty
3. Vijetha Chiniga
4. Vinod Arora
5. Preetam Holkar
6. Yogesh Thakur
7. Jay Tatake
8. Randall Barton
9. Neelam Holkar
10. Bethany Pond

Reviewed by ScreenIT

Nanoviricide’s platform technology based NV-CoV-2 polymer increases the half-life of Remdesivir in vivo

1. Ashok Chakraborty
2. Anil Diwan
3. Vinod Arora
4. Yogesh Thakur
5. Vijetha Chiniga
6. Jay Tatake
7. Preetam Holkar
8. Neelam Holkar
9. Bethany Pond

Reviewed by ScreenIT