Pharmacology and Toxicology

  1. Chronic alcohol intake regulates expression of SARS‐CoV2 infection‐relevant genes in an organ‐specific manner

    1. Marion M. Friske
    2. Francesco Giannone
    3. Mona Senger
    4. Robin Seitz
    5. Anita C. Hansson
    6. Rainer Spanagel

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. Harringtonine has the effects of double blocking SARS-CoV-2 membrane fusion

    1. Shiling Hu
    2. Nan Wang
    3. Shaohong Chen
    4. Qiang Ding
    5. Cheng Wang
    6. Weina Ma
    7. Xinghai Zhang
    8. Yan Wu
    9. Yanni Lv
    10. Zhuoyin Xue
    11. Haoyun Bai
    12. Shuai Ge
    13. Huaizhen He
    14. Wen Lu
    15. Tao Zhang
    16. Yuanyuan Ding
    17. Rui Liu
    18. Shengli Han
    19. Yingzhuan Zhan
    20. Guanqun Zhan
    21. Zengjun Guo
    22. Yongjing Zhang
    23. Jiayu Lu
    24. Jiapan Gao
    25. Qianqian Jia
    26. Yuejin Wang
    27. Hongliang Wang
    28. Shemin Lu
    29. Huajun Zhang
    30. Langchong He

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats

    1. JP Johnson
    2. Thilo Focken
    3. Kuldip Khakh
    4. Parisa Karimi Tari
    5. Celine Dube
    6. Samuel J Goodchild
    7. Jean-Christophe Andrez
    8. Girish Bankar
    9. David Bogucki
    10. Kristen Burford
    11. Elaine Chang
    12. Sultan Chowdhury
    13. Richard Dean
    14. Gina de Boer
    15. Shannon Decker
    16. Christoph Dehnhardt
    17. Mandy Feng
    18. Wei Gong
    19. Michael Grimwood
    20. Abid Hasan
    21. Angela Hussainkhel
    22. Qi Jia
    23. Stephanie Lee
    24. Jenny Li
    25. Sophia Lin
    26. Andrea Lindgren
    27. Verner Lofstrand
    28. Janette Mezeyova
    29. Rostam Namdari
    30. Karen Nelkenbrecher
    31. Noah Gregory Shuart
    32. Luis Sojo
    33. Shaoyi Sun
    34. Matthew Taron
    35. Matthew Waldbrook
    36. Diana Weeratunge
    37. Steven Wesolowski
    38. Aaron Williams
    39. Michael Wilson
    40. Zhiwei Xie
    41. Rhena Yoo
    42. Clint Young
    43. Alla Zenova
    44. Wei Zhang
    45. Alison J Cutts
    46. Robin P Sherrington
    47. Simon N Pimstone
    48. Raymond Winquist
    49. Charles J Cohen
    50. James R Empfield

    • Curated by eLife

      Evaluation Summary:

      This exciting study reports on the characterization of a novel compound that preferentially targets Nav1.6 voltage-gated sodium channels and shows substantial activity against epilepsy associated SCN8A mutations and seizure activity in a variety of animal models. This compound and approach has significant promise to be translated into a therapeutic for individuals with treatment resistant epilepsy.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  4. Favipiravir, umifenovir and camostat mesylate: a comparative study against SARS-CoV-2

    1. Mehnmet Altay Unal
    2. Omur Besbinar
    3. Hasan Nazir
    4. Gokce Yagmur Summak
    5. Fatma Bayrakdar
    6. Lucia Gemma Delogu
    7. Tambay Taskin
    8. Sibel Aysil Ozkan
    9. Kamil Can Akcali
    10. Acelya Yilmazer

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Effect of cannabidiol on apoptosis and cellular interferon and interferon-stimulated gene responses to the SARS-CoV-2 genes ORF8, ORF10 and M protein

    1. Maria Fernanda Fernandes
    2. John Zewen Chan
    3. Chia Chun Joey Hung
    4. Michelle Victoria Tomczewski
    5. Robin Elaine Duncan

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels

    1. Erika Cecon
    2. Daniela Fernandois
    3. Nicolas Renault
    4. Caio Fernando Ferreira Coelho
    5. Jan Wenzel
    6. Corentin Bedart
    7. Charlotte Izabelle
    8. Sarah Gallet
    9. Sophie Le Poder
    10. Bernard Klonjkowski
    11. Markus Schwaninger
    12. Vincent Prevot
    13. Julie Dam
    14. Ralf Jockers

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants

    1. Lianghui Zhang
    2. Soumajit Dutta
    3. Shiqin Xiong
    4. Matthew Chan
    5. Kui K. Chan
    6. Timothy M. Fan
    7. Keith L. Bailey
    8. Matthew Lindeblad
    9. Laura M. Cooper
    10. Lijun Rong
    11. Anthony F. Gugliuzza
    12. Diwakar Shukla
    13. Erik Procko
    14. Jalees Rehman
    15. Asrar B. Malik

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Fluorescence activation mechanism and imaging of drug permeation with new sensors for smoking-cessation ligands

    1. Aaron L Nichols
    2. Zack Blumenfeld
    3. Chengcheng Fan
    4. Laura Luebbert
    5. Annet EM Blom
    6. Bruce N Cohen
    7. Jonathan S Marvin
    8. Philip M Borden
    9. Charlene H Kim
    10. Anand K Muthusamy
    11. Amol V Shivange
    12. Hailey J Knox
    13. Hugo Rego Campello
    14. Jonathan H Wang
    15. Dennis A Dougherty
    16. Loren L Looger
    17. Timothy Gallagher
    18. Douglas C Rees
    19. Henry A Lester

    • Curated by eLife

      Evaluation Summary:

      Nichols et al. developed and characterized the first fluorescent sensors for several nicotinic receptor partial agonists relevant to smoking cessation. It is potentially a major advance for the field. They leveraged crystallography to understand the mechanism by which the ligands enhance fluorescence, then characterized top sensors for sensitivity, selectivity, and kinetics, and their utility in plasma membrane and ER sensing in neurons and cell lines. The tools developed by this team will enable investigators to track nicotinic receptor partial agonists in different subcellular compartments with relatively fast time resolution.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  9. Potential inhibitors for blocking the interaction of the coronavirus SARS-CoV-2 spike protein and its host cell receptor ACE2

    1. Changzhi Li
    2. Hongjuan Zhou
    3. Lingling Guo
    4. Dehuan Xie
    5. Huiping He
    6. Hong Zhang
    7. Yixiu Liu
    8. Lixia Peng
    9. Lisheng Zheng
    10. Wenhua Lu
    11. Yan Mei
    12. Zhijie Liu
    13. Jie Huang
    14. Mingdian Wang
    15. Ditian Shu
    16. Liuyan Ding
    17. Yanhong Lang
    18. Feifei Luo
    19. Jing Wang
    20. Bijun Huang
    21. Peng Huang
    22. Song Gao
    23. Jindong Chen
    24. Chao-Nan Qian

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. The Petasites hybridus CO2 Extract (Ze 339) Blocks SARS-CoV-2 Replication In Vitro

    1. Lorena Urda
    2. Matthias Heinrich Kreuter
    3. Jürgen Drewe
    4. Georg Boonen
    5. Veronika Butterweck
    6. Thomas Klimkait

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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