Pathology

Activin A marks a novel progenitor cell population during fracture healing and reveals a therapeutic strategy

1. Lutian Yao
2. Jiawei Lu
3. Leilei Zhong
4. Yulong Wei
5. Tao Gui
6. Luqiang Wang
7. Jaimo Ahn
8. Joel D Boerckel
9. Danielle Rux
10. Christina Mundy
11. Ling Qin
12. Maurizio Pacifici

• Curated by eLife

  eLife assessment

  This work is a valuable presentation of sharp-wave-ripple reactivation of hippocampal neural ensemble activity recorded as animals explored two different environments. It attempts to use the fact that the ensemble code remaps between the two mazes to identify the best replay-detection procedures for analyzing this type of data. The reviewers found the evidence for a prescriptive conclusion inadequate, while still appreciating the concept of comparing maze-identity discrimination with replay.

Reviewed by eLife

A novel sustained release therapy of combined VEGF and TNF-α inhibitors leads to pan-ocular protection for months after severe ocular trauma

1. Chengxin Zhou
2. Fengyang Lei
3. Pui-Chuen Hui
4. Natalie Wolkow
5. Claes H. Dohlman
6. Demetrios G. Vavvas
7. James Chodosh
8. Eleftherios I. Paschalis

Reviewed by PREreview

Mouse gingival single-cell transcriptomic atlas identified a novel fibroblast subpopulation activated to guide oral barrier immunity in periodontitis

1. Takeru Kondo
2. Annie Gleason
3. Hiroko Okawa
4. Akishige Hokugo
5. Ichiro Nishimura

• Curated by eLife

  eLife assessment

  The findings of this article provide valuable information on the changes of cell clusters induced by chronic periodontitis. The observation of a new fibroblast subpopulation, named AG fibroblasts, is interesting, and the strength of evidence presented is solid.

Reviewed by eLife