Pathology

Discovery and characterization of cross-reactive intrahepatic antibodies in severe alcoholic hepatitis

1. Ali Reza Ahmadi
2. Guang Song
3. Tianshun Gao
4. Jing Ma
5. Xiaomei Han
6. Ming-Wen Hu
7. Andrew M Cameron
8. Russell N Wesson
9. Benjamin Philosophe
10. Shane Ottmann
11. Elizabeth King
12. Ahmet Gurakar
13. Le Qi
14. Brandon Peiffer
15. James Burdick
16. Robert Anders
17. Zhanxiang Zhou
18. Hongkun Lu
19. Dechun Feng
20. Chien-Sheng Chen
21. Jiang Qian
22. Bin Gao
23. Heng Zhu
24. Zhaoli Sun

• Curated by eLife

  eLife assessment

  This important study tested the hypothesis that liver-derived but not serum-derived antibodies that are cross-reactive to E.coli and to host proteins can play a role in the hepatic damage found in severe alcoholic hepatitis (SAH). Using a solid methodology that includes state-of-the-art microscopy, proteome arrays, and gene ontology assays, it provides strong evidence that liver-derived IgG and IgA with cytotoxic properties and reactivity to both gut-derived E.coli and autoantigens accumulated in hepatocytes of SAH patients but not of healthy controls. The study would benefit from a broader analysis of gut microbiota proteome and further characterization of B cells infiltrating the liver tissue including their numbers/field and their origin (infiltrating versus resident cells). The work opens new avenues of understanding for the pathogenesis of severe alcoholic hepatitis and is of great interest to researchers and clinicians in the field.

Reviewed by eLife

Integrative single cell and spatial transcriptomic analysis reveal reciprocal microglia-plasma cell crosstalk in the mouse brain during chronic Trypanosoma brucei infection

1. Juan F. Quintana
2. Praveena Chandrasegaran
3. Matthew C. Sinton
4. Emma Briggs
5. Thomas D. Otto
6. Rhiannon Heslop
7. Calum Bentley-Abbot
8. Colin Loney
9. Luis de Lecea
10. Neil A. Mabbott
11. Annette MacLeod

Reviewed by preLights

The quasi-universality of nestedness in the structure of quantitative plant-parasite interactions

1. Moury Benoît
2. Audergon Jean-Marc
3. Baudracco-Arnas Sylvie
4. Ben Krima Safa
5. Bertrand François
6. Boissot Nathalie
7. Buisson Mireille
8. Caffier Valérie
9. Cantet Mélissa
10. Chanéac Sylvia
11. Constant Carole
12. Delmotte François
13. Dogimont Catherine
14. Doumayrou Juliette
15. Fabre Frédéric
16. Fournet Sylvain
17. Grimault Valérie
18. Jaunet Thierry
19. Justafré Isabelle
20. Lefebvre Véronique
21. Losdat Denis
22. C. Marcel Thierry
23. Montarry Josselin
24. E. Morris Cindy
25. Omrani Mariem
26. Paineau Manon
27. Perrot Sophie
28. Pilet-Nayel Marie-Laure
29. Ruellan Youna

Reviewed by Peer Community in Evolutionary Biology

Hepatocyte-specific deletion of Pparα promotes NASH in the context of obesity

1. Marion Régnier
2. Arnaud Polizzi
3. Sarra Smati
4. Céline Lukowicz
5. Anne Fougerat
6. Yannick Lippi
7. Edwin Fouché
8. Frédéric Lasserre
9. Claire Naylies
10. Colette Bétoulières
11. Valentin Barquissau
12. Etienne Mouisel
13. Justine Bertrand-Michel
14. Aurélie Batut
15. Talal Al Saati
16. Cécile Canlet
17. Marie Tremblay-Franco
18. Sandrine Ellero-Simatos
19. Dominique Langin
20. Catherine Postic
21. Walter Wahli
22. Nicolas Loiseau
23. Hervé Guillou
24. Alexandra Montagner

Reviewed by preLights

Intraperitoneal oil application causes local inflammation with depletion of resident peritoneal macrophages

1. Elisenda Alsina-Sanchis
2. Ronja Mülfarth
3. Iris Moll
4. Carolin Mogler
5. Juan Rodriguez-Vita
6. Andreas Fischer

Reviewed by preLights

Interstitial spaces are continuous across tissue and organ boundaries in humans

1. Odise Cenaj
2. Douglas H. R. Allison
3. R Imam
4. Briana Zeck
5. Lilly M. Drohan
6. Luis Chiriboga
7. Jessica Llewellyn
8. Cheng Z Liu
9. Young Nyun Park
10. Rebecca G. Wells
11. Neil D. Theise

Reviewed by preLights