Pathology

COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital

1. Kiran T Thakur
2. Emily Happy Miller
3. Michael D Glendinning
4. Osama Al-Dalahmah
5. Matei A Banu
6. Amelia K Boehme
7. Alexandra L Boubour
8. Samuel S Bruce
9. Alexander M Chong
10. Jan Claassen
11. Phyllis L Faust
12. Gunnar Hargus
13. Richard A Hickman
14. Sachin Jambawalikar
15. Alexander G Khandji
16. Carla Y Kim
17. Robyn S Klein
18. Angela Lignelli-Dipple
19. Chun-Chieh Lin
20. Yang Liu
21. Michael L Miller
22. Gul Moonis
23. Anna S Nordvig
24. Jonathan B Overdevest
25. Morgan L Prust
26. Serge Przedborski
27. William H Roth
28. Allison Soung
29. Kurenai Tanji
30. Andrew F Teich
31. Dritan Agalliu
32. Anne-Catrin Uhlemann
33. James E Goldman
34. Peter Canoll

Reviewed by ScreenIT

Sequence Analysis of 20,453 Severe Acute Respiratory Syndrome Coronavirus 2 Genomes from the Houston Metropolitan Area Identifies the Emergence and Widespread Distribution of Multiple Isolates of All Major Variants of Concern

1. S. Wesley Long
2. Randall J. Olsen
3. Paul A. Christensen
4. Sishir Subedi
5. Robert Olson
6. James J. Davis
7. Matthew Ojeda Saavedra
8. Prasanti Yerramilli
9. Layne Pruitt
10. Kristina Reppond
11. Madison N. Shyer
12. Jessica Cambric
13. Ilya J. Finkelstein
14. Jimmy Gollihar
15. James M. Musser

Reviewed by ScreenIT

Repeated Testing Necessary: Assessing Negative Predictive Value of SARS-CoV-2 qPCR in a Population of Young Adults

1. Elaine E. Thompson
2. Joseph H. Rosenthal
3. James Wren
4. Erik Seetao
5. Niels H. Olson

Reviewed by ScreenIT

Performance Decay of Molecular Assays Near the Limit of Detection: Probabilistic Modeling using Real-World COVID-19 Data

1. Thomas J.S. Durant
2. Christopher D. Koch
3. Christopher A. Kerantzas
4. David R. Peaper

Reviewed by ScreenIT

Molecular Profiling of Coronavirus Disease 2019 (COVID-19) Autopsies Uncovers Novel Disease Mechanisms

1. Elisabet Pujadas
2. Michael Beaumont
3. Hardik Shah
4. Nadine Schrode
5. Nancy Francoeur
6. Sanjana Shroff
7. Clare Bryce
8. Zachary Grimes
9. Jill Gregory
10. Ryan Donnelly
11. Mary E. Fowkes
12. Kristin G. Beaumont
13. Robert Sebra
14. Carlos Cordon-Cardo

Reviewed by ScreenIT

Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area

1. S. Wesley Long
2. Randall J. Olsen
3. Paul A. Christensen
4. David W. Bernard
5. James J. Davis
6. Maulik Shukla
7. Marcus Nguyen
8. Matthew Ojeda Saavedra
9. Prasanti Yerramilli
10. Layne Pruitt
11. Sishir Subedi
12. Hung-Che Kuo
13. Heather Hendrickson
14. Ghazaleh Eskandari
15. Hoang A. T. Nguyen
16. J. Hunter Long
17. Muthiah Kumaraswami
18. Jule Goike
19. Daniel Boutz
20. Jimmy Gollihar
21. Jason S. McLellan
22. Chia-Wei Chou
23. Kamyab Javanmardi
24. Ilya J. Finkelstein
25. James M. Musser

Reviewed by ScreenIT, NCRC

Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease

1. Gang Wu
2. Yin Yeng Lee
3. Evelyn M Gulla
4. Andrew Potter
5. Joseph Kitzmiller
6. Marc D Ruben
7. Nathan Salomonis
8. Jeffery A Whitsett
9. Lauren J Francey
10. John B Hogenesch
11. David F Smith

• Curated by eLife

  Summary: Obstructive sleep apnea is an important medical problem, with elevated cardiovascular risk as a common association. Intermittent hypoxic episodes are a good predictor of such risk so a connection is indeed plausible. The authors use single cell genomics to delineate the changes in intermittent hypoxia models, with interesting insights, but what limits enthusiasm is validation of some hypothesis generating findings from single cell data, limiting potential mechanistic insights that are translatable to OSA.

Reviewed by eLife

Discovery and characterization of cross-reactive intrahepatic antibodies in severe alcoholic hepatitis

1. Ali Reza Ahmadi
2. Guang Song
3. Tianshun Gao
4. Jing Ma
5. Xiaomei Han
6. Ming-Wen Hu
7. Andrew M Cameron
8. Russell N Wesson
9. Benjamin Philosophe
10. Shane Ottmann
11. Elizabeth King
12. Ahmet Gurakar
13. Le Qi
14. Brandon Peiffer
15. James Burdick
16. Robert Anders
17. Zhanxiang Zhou
18. Hongkun Lu
19. Dechun Feng
20. Chien-Sheng Chen
21. Jiang Qian
22. Bin Gao
23. Heng Zhu
24. Zhaoli Sun

• Curated by eLife

  eLife assessment

  This important study tested the hypothesis that liver-derived but not serum-derived antibodies that are cross-reactive to E.coli and to host proteins can play a role in the hepatic damage found in severe alcoholic hepatitis (SAH). Using a solid methodology that includes state-of-the-art microscopy, proteome arrays, and gene ontology assays, it provides strong evidence that liver-derived IgG and IgA with cytotoxic properties and reactivity to both gut-derived E.coli and autoantigens accumulated in hepatocytes of SAH patients but not of healthy controls. The study would benefit from a broader analysis of gut microbiota proteome and further characterization of B cells infiltrating the liver tissue including their numbers/field and their origin (infiltrating versus resident cells). The work opens new avenues of understanding for the pathogenesis of severe alcoholic hepatitis and is of great interest to researchers and clinicians in the field.

Reviewed by eLife

Integrative single cell and spatial transcriptomic analysis reveal reciprocal microglia-plasma cell crosstalk in the mouse brain during chronic Trypanosoma brucei infection

1. Juan F. Quintana
2. Praveena Chandrasegaran
3. Matthew C. Sinton
4. Emma Briggs
5. Thomas D. Otto
6. Rhiannon Heslop
7. Calum Bentley-Abbot
8. Colin Loney
9. Luis de Lecea
10. Neil A. Mabbott
11. Annette MacLeod

Reviewed by preLights

The quasi-universality of nestedness in the structure of quantitative plant-parasite interactions

1. Benoît Moury
2. Jean-Marc Audergon
3. Sylvie Baudracco-Arnas
4. Safa Ben Krima
5. François Bertrand
6. Nathalie Boissot
7. Mireille Buisson
8. Valérie Caffier
9. Mélissa Cantet
10. Sylvia Chanéac
11. Carole Constant
12. François Delmotte
13. Catherine Dogimont
14. Juliette Doumayrou
15. Frédéric Fabre
16. Sylvain Fournet
17. Valérie Grimault
18. Thierry Jaunet
19. Isabelle Justafré
20. Véronique Lefebvre
21. Denis Losdat
22. Thierry C. Marcel
23. Josselin Montarry
24. Cindy E. Morris
25. Mariem Omrani
26. Manon Paineau
27. Sophie Perrot
28. Marie-Laure Pilet-Nayel
29. Youna Ruellan

Reviewed by Peer Community in Evolutionary Biology