Pathology

Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease

1. Gang Wu
2. Yin Yeng Lee
3. Evelyn M Gulla
4. Andrew Potter
5. Joseph Kitzmiller
6. Marc D Ruben
7. Nathan Salomonis
8. Jeffery A Whitsett
9. Lauren J Francey
10. John B Hogenesch
11. David F Smith

• Curated by eLife

  Summary: Obstructive sleep apnea is an important medical problem, with elevated cardiovascular risk as a common association. Intermittent hypoxic episodes are a good predictor of such risk so a connection is indeed plausible. The authors use single cell genomics to delineate the changes in intermittent hypoxia models, with interesting insights, but what limits enthusiasm is validation of some hypothesis generating findings from single cell data, limiting potential mechanistic insights that are translatable to OSA.

Reviewed by eLife

Discovery and characterization of cross-reactive intrahepatic antibodies in severe alcoholic hepatitis

1. Ali Reza Ahmadi
2. Guang Song
3. Tianshun Gao
4. Jing Ma
5. Xiaomei Han
6. Ming-Wen Hu
7. Andrew M Cameron
8. Russell N Wesson
9. Benjamin Philosophe
10. Shane Ottmann
11. Elizabeth King
12. Ahmet Gurakar
13. Le Qi
14. Brandon Peiffer
15. James Burdick
16. Robert Anders
17. Zhanxiang Zhou
18. Hongkun Lu
19. Dechun Feng
20. Chien-Sheng Chen
21. Jiang Qian
22. Bin Gao
23. Heng Zhu
24. Zhaoli Sun

• Curated by eLife

  eLife assessment

  This important study tested the hypothesis that liver-derived but not serum-derived antibodies that are cross-reactive to E.coli and to host proteins can play a role in the hepatic damage found in severe alcoholic hepatitis (SAH). Using a solid methodology that includes state-of-the-art microscopy, proteome arrays, and gene ontology assays, it provides strong evidence that liver-derived IgG and IgA with cytotoxic properties and reactivity to both gut-derived E.coli and autoantigens accumulated in hepatocytes of SAH patients but not of healthy controls. The study would benefit from a broader analysis of gut microbiota proteome and further characterization of B cells infiltrating the liver tissue including their numbers/field and their origin (infiltrating versus resident cells). The work opens new avenues of understanding for the pathogenesis of severe alcoholic hepatitis and is of great interest to researchers and clinicians in the field.

Reviewed by eLife

Integrative single cell and spatial transcriptomic analysis reveal reciprocal microglia-plasma cell crosstalk in the mouse brain during chronic Trypanosoma brucei infection

1. Juan F. Quintana
2. Praveena Chandrasegaran
3. Matthew C. Sinton
4. Emma Briggs
5. Thomas D. Otto
6. Rhiannon Heslop
7. Calum Bentley-Abbot
8. Colin Loney
9. Luis de Lecea
10. Neil A. Mabbott
11. Annette MacLeod

Reviewed by preLights

The quasi-universality of nestedness in the structure of quantitative plant-parasite interactions

1. Benoît Moury
2. Jean-Marc Audergon
3. Sylvie Baudracco-Arnas
4. Safa Ben Krima
5. François Bertrand
6. Nathalie Boissot
7. Mireille Buisson
8. Valérie Caffier
9. Mélissa Cantet
10. Sylvia Chanéac
11. Carole Constant
12. François Delmotte
13. Catherine Dogimont
14. Juliette Doumayrou
15. Frédéric Fabre
16. Sylvain Fournet
17. Valérie Grimault
18. Thierry Jaunet
19. Isabelle Justafré
20. Véronique Lefebvre
21. Denis Losdat
22. Thierry C. Marcel
23. Josselin Montarry
24. Cindy E. Morris
25. Mariem Omrani
26. Manon Paineau
27. Sophie Perrot
28. Marie-Laure Pilet-Nayel
29. Youna Ruellan

Reviewed by Peer Community in Evolutionary Biology

Evidence for continuity of interstitial spaces across tissue and organ boundaries in humans

1. Odise Cenaj
2. Douglas H. R. Allison
3. Rami Imam
4. Briana Zeck
5. Lilly M. Drohan
6. Luis Chiriboga
7. Jessica Llewellyn
8. Cheng Z. Liu
9. Young Nyun Park
10. Rebecca G. Wells
11. Neil D. Theise

Reviewed by preLights

Hepatocyte-specific deletion of Pparα promotes NASH in the context of obesity

1. Marion Régnier
2. Arnaud Polizzi
3. Sarra Smati
4. Céline Lukowicz
5. Anne Fougerat
6. Yannick Lippi
7. Edwin Fouché
8. Frédéric Lasserre
9. Claire Naylies
10. Colette Bétoulières
11. Valentin Barquissau
12. Etienne Mouisel
13. Justine Bertrand-Michel
14. Aurélie Batut
15. Talal Al Saati
16. Cécile Canlet
17. Marie Tremblay-Franco
18. Sandrine Ellero-Simatos
19. Dominique Langin
20. Catherine Postic
21. Walter Wahli
22. Nicolas Loiseau
23. Hervé Guillou
24. Alexandra Montagner

Reviewed by preLights

Data from Intraperitoneal Oil Application Causes Local Inflammation with Depletion of Resident Peritoneal Macrophages

1. Elisenda Alsina-Sanchis
2. Ronja Mülfarth
3. Iris Moll
4. Carolin Mogler
5. Juan Rodriguez-Vita
6. Andreas Fischer

Reviewed by preLights