1. NDR kinase SAX-1 controls dendrite branch-specific elimination during neuronal remodeling in C. elegans

    This article has 2 authors:
    1. Paola V. Figueroa-Delgado
    2. Shaul Yogev

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments

    This article has 7 authors:
    1. Sofia Lövestam
    2. Jane L Wagstaff
    3. Taxiarchis Katsinelos
    4. Jenny Shi
    5. Stefan MV Freund
    6. Michel Goedert
    7. Sjors HW Scheres
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This fundamental study will allow in vitro mechanistic investigations. The presented evidence is convincing. This manuscript will be of interest to all scientists in the amyloid formation field.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  3. Representation of male features in the female mouse Accessory Olfactory Bulb, and their stability during the estrus cycle

    This article has 2 authors:
    1. Oksana Cohen
    2. Yoram Ben-Shaul
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work substantially advances our understanding of how accessory olfactory bulb neurons respond to social odor cues across the estrous cycle, showing that responses vary with the strain and sex of the odor source but display no consistent differences between estrous and non-estrous states. It employs a unique electrophysiology preparation that activates the vomeronasal organ pump via electric stimulation, enabling precise recordings of accessory olfactory bulb cell responses to different chemosignals in anesthetized mice. Overall, the study presents convincing findings on the stability and variability of accessory olfactory bulb response patterns, indicating that while accessory olfactory bulb detects social signals, it does not appear to interpret them based on reproductive state. This work will be of interest to those studying olfaction, social behavior, reproductive cycles, and systems neuroscience more broadly.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  4. High Cognitive Violation of Expectations is Compromised in Cerebellar Ataxia

    This article has 3 authors:
    1. Leonardo A Daniel
    2. Eli Vakil
    3. William Saban
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable investigation provides new and solid evidence for a specific cognitive deficit in cerebellar degeneration patients. The authors use three tasks that modulate complexity and violations of cognitive expectations. They show specific slowing of reaction times in the presence of violations but not with task complexity. While some alternative interpretations of the results are possible and are discussed, the work provides a new, invaluable data point in describing the cognitive contribution of cerebellar processing.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  5. Age and Learning Shapes Sound Representations in Auditory Cortex During Adolescence

    This article has 6 authors:
    1. Benedikt Praegel
    2. Feng Chen
    3. Adria Dym
    4. Amichai Lavi-Rudel
    5. Shaul Druckmann
    6. Adi Mizrahi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study suggests that adolescent mice exhibit less accuracy than adult mice in a sound discrimination task when the sound frequencies are very similar. The evidence supporting this observation is solid and suggests that it arises from cognitive control differences between adolescent and adult mice. The adolescent period is largely understudied, despite its contribution to shaping the adult brain, which makes this study interesting for a broad range of neuroscientists.

    Reviewed by eLife

    This article has 13 evaluationsAppears in 1 listLatest version Latest activity
  6. Task structure tailors the geometry of neural representations in human lateral prefrontal cortex

    This article has 4 authors:
    1. Apoorva Bhandari
    2. Haley Keglovits
    3. Defne Buyukyazgan
    4. David Badre
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents a valuable finding on the representational structure of task encoding in the prefrontal cortex. The evidence supporting the claims of the authors is solid, representing an impressive data collection effort and best-practice fMRI analyses. However, at least including visual regions as a control and controlling for behavioral differences in the task in representation analyses would have strengthened the study. The work will be of interest to cognitive neuroscientists interested in the neural basis of cognitive control.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  7. Nanophysiology Approach Reveals Diversity in Calcium Microdomains across Zebrafish Retinal Bipolar Ribbon Synapses

    This article has 7 authors:
    1. Nirujan Rameshkumar
    2. Abhishek P Shrestha
    3. Johane M Boff
    4. Mrinalini Hoon
    5. Victor Matveev
    6. David Zenisek
    7. Thirumalini Vaithianathan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The study introduces new tools for measuring the intracellular calcium concentration close to transmitter release sites, which may be relevant for synaptic vesicle fusion and replenishment. This approach yields important new information about the spatial and temporal profile of calcium concentrations near the site of entry at the plasma membrane. This experimental work is complemented by a coherent, open-source, computational model that successfully describes changes in calcium domains. The conclusions are solid and well supported by the data.

    Reviewed by eLife

    This article has 15 evaluationsAppears in 1 listLatest version Latest activity
  8. NeuroSC: Exploring Neurodevelopment via Spatiotemporal Collation of Anatomical Networks

    This article has 11 authors:
    1. Noelle L Koonce
    2. Sarah E Emerson
    3. Dhananjay Bhaskar
    4. Manik Kuchroo
    5. Mark W Moyle
    6. Pura Arroyo-Morales
    7. Nabor Vázquez Martínez
    8. Jamie I Emerson
    9. Smita Krishnaswamy
    10. William Mohler
    11. Daniel Colón-Ramos
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      NeuroSC is an accessible and interactive tool for streamlined observation of neuronal morphology, membrane contact, and synaptic connectivity across developmental stages in the nematode C. elegans. This important tool relies on solid electron microscopy datasets. This resource will be of high interest to C. elegans researchers interested in nervous system wiring and circuit function.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  9. Coordinated dynamics of excitatory and inhibitory synapse assembly

    This article has 3 authors:
    1. Krassimira Garbett
    2. James Allen
    3. Richard C Sando
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this valuable study, the authors developed long-term imaging tools to simultaneously monitor the temporal and spatial dynamics of excitatory and inhibitory synapses and reported that excitatory and inhibitory synapses need to develop synergistically during synaptogenesis to maintain balance. While the analysis and quantification of the imaging data are incomplete, there is convincing evidence that the developed tools are feasible. If these tools can function stably in vivo, their applications will be much broader.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. Dynamics of mesoscale brain network during decision-making learning revealed by chronic, large-scale single-unit recording

    This article has 5 authors:
    1. Tian-Yi Wang
    2. Chengcong Feng
    3. Chengyao Wang
    4. Chi Ren
    5. Zhengtuo Zhao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents experiments suggesting intriguing mesoscale reorganization of functional connectivity across distributed cortical and subcortical circuits during learning. The approach is technically impressive and the results are potentially of valuable significance. However, in its current form, the strength of evidence is incomplete. More in-depth analyses and the acquisition of data from additional animals in the primary experiment could bolster these findings.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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