Neuroscience

Spontaneous fluctuations in global connectivity reflect transitions between states of high and low prediction error

1. Paul C Bogdan
2. Shenyang Huang
3. Lifu Deng
4. Simon W Davis
5. Roberto Cabeza

• Curated by eLife

  eLife Assessment

  This study uses a valuable combination of functional magnetic resonance imaging and electroencephalography (EEG) to study brain activity related to prediction errors in relation to both sensorimotor and more complex cognitive functions. It provides incomplete evidence to suggest that prediction error minimisation drives brain activity across both types of processing and that elevated inter-regional functional coupling along a superior-inferior axis is associated with high prediction error, whereas coupling along a posterior-anterior axis is associated with low prediction error. The manuscript will be of interest to neuroscientists working on predictive coding and decision-making, but would benefit from more precise localisation of EEG sources and more rigorous statistical controls.

Reviewed by eLife

Multi-talker speech comprehension at different temporal scales in listeners with normal and impaired hearing

1. Jixing Li
2. Qixuan Wang
3. Qian Zhou
4. Lu Yang
5. Yutong Shen
6. Shujian Huang
7. Shaonan Wang
8. Liina Pylkkänen
9. Zhiwu Huang

• Curated by eLife

  eLife Assessment

  This valuable study a computational language model, i.e., HM-LSTM, to quantify the neural encoding of hierarchical linguistic information in speech, and addresses how hearing impairment affects neural encoding of speech. Overall the evidence for the findings is solid, although the evidence for different speech processing stages could be strengthened by a more rigorous temporal response function (TRF) analysis. The study is of potential interest to audiologists and researchers who are interested in the neural encoding of speech.

Reviewed by eLife

Involuntary feedback responses reflect a representation of partner actions

1. Seth R Sullivan
2. John H Buggeln
3. Jan A Calalo
4. Truc T Ngo
5. Jennifer A Semrau
6. Michael J Carter
7. Joshua GA Cashaback

• Curated by eLife

  eLife Assessment

  This important study combines a two-person joint hand-reaching paradigm with game-theoretical modeling to examine whether, and how, one's reflexive visuomotor responses are modulated by a partner's control policy and cost structure. The study provides a solid and novel set of behavioral findings suggesting that involuntary visuomotor feedback is indeed modulated in the context of interpersonal coordination. The work will be of interest to cognitive scientists studying the motoric and social aspects of action control.

Reviewed by eLife

Concurrent category-selective neural activity across the ventral occipito-temporal cortex supports a non-hierarchical view of human visual recognition

1. Corentin Jacques
2. Jacques Jonas
3. Sophie Colnat-Coulbois
4. Bruno Rossion

• Curated by eLife

  eLife Assessment

  This important study addresses a classic debate in visual processing, using a strong method applied to a rare clinical population to evaluate hierarchical models of visual object perception. The paper finds only partial support for the hierarchical model: as expected, neural responses in ventral visual cortex show increased representational selectivity for faces along the posterior-anterior axes, but the onsets of the signals do not show a temporal hierarchy, indicating more parallel processing. The iEEG dataset is impressive, but the evidence for lack of temporal hierarchy is incomplete: essential quality checks need to be performed, and statistical analyses adapted to ensure that the data and analyses would be able to reveal temporal hierarchy if it were present in the data.

Reviewed by eLife

Subregional activity in the dentate gyrus is amplified during elevated cognitive demands

1. Charlotte CM Castillon
2. Shintaro Otsuka
3. John N Armstrong
4. Anis Contractor

• Curated by eLife

  eLife Assessment

  This manuscript presents a valuable study of the activity and functional relevance of different circuits in the dentate gyrus of mice performing a pattern separation task. The study is likely to be of interest to those studying the subregional organization and cell type-specific functions of the dentate gyrus. However, the strength of evidence for the study's conclusions is currently incomplete.

Reviewed by eLife

Improved inference of latent neural states from calcium imaging data

1. Stephen Keeley
2. David Zoltowski
3. Adam Charles
4. Jonathan Pillow

• Curated by eLife

  eLife Assessment

  This valuable study provides a practical computational framework for inferring latent neural states directly from calcium fluorescence recordings, bypassing the traditional need for a separate spike deconvolution step. The evidence supporting the method is solid, featuring rigorous validation across multiple latent variable model families (including HMM, GPFA, and LFADS) using both simulated and experimental data. However, the assessment of the method's generality would be further strengthened by application to a broader range of experimental datasets, such as recordings from different brain regions or using different calcium indicators.

Reviewed by eLife

Dual-feature selectivity enables bidirectional coding in visual cortical neurons

1. Katrin Franke
2. Nikos Karantzas
3. Konstantin Willeke
4. Maria Diamantaki
5. Kandan Ramakrishnan
6. Hasan Atakan Bedel
7. Pavithra Elumalai
8. Kelli Restivo
9. Paul Fahey
10. Cate Nealley
11. Tori Shinn
12. Gabrielle Garcia
13. Saumil Patel
14. Alexander Ecker
15. Edgar Y Walker
16. Emmanouil Froudarakis
17. Sophia Sanborn
18. Fabian H Sinz
19. Andreas Tolias

• Curated by eLife

  eLife Assessment

  The authors combine a modeling approach, using a digital twin, with electrophysiological evidence in two species to assess the role of inhibition in shaping selectivity in the visual cortex. The results provide an important advance beyond the classic view of sensory coding by proving compelling evidence that many neurons in visual areas exhibit dual-feature selectivity. Overall, the work exceptionally showcases how in silico experiments can generate concrete hypotheses about neuronal coding that are difficult to discover experimentally.

Reviewed by eLife

Distinct goal location beta frequency dynamics in hippocampus and prefrontal cortex across learning

1. Glingna Wang
2. Nan Zhou
3. Zachary M Leveroni
4. Jai Y Yu

• Curated by eLife

  eLife Assessment

  This paper represents a valuable contribution to our understanding of how LFP oscillations and beta band coordination between the hippocampus and prefrontal cortex of rats may relate to learning. Enthusiasm for the reported results was moderated by the concern that some key analyses need to be done, and highly relevant details about task, data, and statistics were missing. Consequently, the reviewers considered the evidence to be incomplete in this version of the manuscript.

Reviewed by eLife

Trisomy 21 Impairs Synchronized Activity in Human Down Syndrome Cortical Excitatory Neuron Networks

1. Manuel Peter
2. Raquel Real
3. Alessio Strano
4. Hugh P. C. Robinson
5. Mark A. Smith
6. Samuel J. Barnes
7. Tania Dutta
8. Vincenzo De Paola
9. Frederick J. Livesey

Reviewed by Review Commons

A forebrain hub for cautious actions via the midbrain

1. Ji Zhou
2. Muhammad Sarmad Sajid
3. Sebastian Hormigo
4. Manuel A Castro-Alamancos

• Curated by eLife

  eLife Assessment

  This valuable study uses fiber photometry, implantable lenses, and optogenetics, to show that a subset of subthalamic nucleus neurons are active during movement, and that active but not passive avoidance depends in part on STN projections to substantia nigra. The strength of the evidence for these claims is solid and this paper may be of interest to basic and applied behavioural neuroscientists working on movement or avoidance.

Reviewed by eLife