Neuroscience

A low-cost FPGA-based approach for pile-up corrected high-speed in vivo FLIM imaging

1. Felipe Velasquez Moros
2. Dorian Amiet
3. Rachel M. Meister
4. Alexandra von Faber-Castell
5. Matthias Wyss
6. Aiman S. Saab
7. Paul Zbinden
8. Bruno Weber
9. Luca Ravotto

Reviewed by Arcadia Science

Whole-brain neural substrates of behavioral variability in the larval zebrafish

1. Jason Manley
2. Alipasha Vaziri

• Curated by eLife

  eLife Assessment

  Manley and Vaziri introduce an important new method for brain-wide imaging of cellular activity in zebrafish and provide evidence for the applicability of this technique. They use this method to explore the question of how neural variability gives rise to variability in behavior. The analyses used are mostly convincing, although questions regarding spatial and temporal imaging resolution and their effects on the study's interpretations and conclusions suggest only partial support for some of the central results.

Reviewed by eLife

microRNA-19b regulates proliferation & patterning in the avian forebrain

1. Archita Mishra
2. Suvimal Kumar Sindhu
3. Niveda Udaykumar
4. Jonaki Sen

• Curated by eLife

  eLife Assessment

  This valuable study provides insights into a key question in comparative neuroanatomy and development. The authors provide evidence of the role for a particular micro-RNA in regulating the development of key transcription factors that control forebrain development. The study rests on clear but incomplete results.

Reviewed by eLife

Single-cell type analysis of wing premotor circuits in the ventral nerve cord of Drosophila melanogaster

1. Erica Ehrhardt
2. Samuel C Whitehead
3. Shigehiro Namiki
4. Ryo Minegishi
5. Igor Siwanowicz
6. Kai Feng
7. Hideo Otsuna
8. FlyLight Project Team
9. Geoffrey W Meissner
10. David Stern
11. James W Truman
12. David Shepherd
13. Michael H Dickinson
14. Kei Ito
15. Barry J Dickson
16. Itai Cohen
17. Gwyneth M Card
18. Wyatt Korff

• Curated by eLife

  eLife Assessment

  This important resource paper presents a library of cell-type-specific genetic driver lines that label wing-related motor and premotor neurons in the ventral nerve cord of the fruit fly, Drosophila. The toolkit is systematically validated with compelling anatomical and behavioral evidence and will provide a resource for future studies of Drosophila flight and courtship.

Reviewed by eLife