Neuroscience

GPR30 in spinal cholecystokinin-positive neurons modulates neuropathic pain via mediating descending facilitation

1. Qing Chen
2. Hui Wu
3. Shulan Xie
4. Fangfang Zhu
5. Fang Xu
6. Qi Xu
7. Lihong Sun
8. Yue Yang
9. Linghua Xie
10. Jiaqian Xie
11. Hua Li
12. Ange Dai
13. Wenxin Zhang
14. Luyang Wang
15. Cuicui Jiao
16. Honghai Zhang
17. Zhen-Zhong Xu
18. Xinzhong Chen

• Curated by eLife

  eLife Assessment

  This valuable study investigates the mechanisms that contribute to nerve-injury-induced allodynia by studying the role of the estrogen receptor GPR30 in a population of CCK+ neurons in the dorsal horn of the spinal cord that receive direct inputs from primary somatosensory cortex and modulate nociceptive sensitivity. The authors provide convincing evidence, using a variety of complementary approaches, ranging from the cellular to physiology level; however, conclusions that descending corticospinal projections modulate nociceptive behaviors through GPR30 are incompletely supported. With some additional analyses, the findings will be better positioned within the context of spinal circuitry literature.

Reviewed by eLife

A brainstem circuit controls cough-like airway defensive behaviors in mice

1. Xiaoshan Xu
2. Xiupeng Nie
3. Weijia Zhang
4. He-Hai Jiang
5. Bingyi Liu
6. Yanyan Ren
7. Tingting Wang
8. Xiang Xu
9. Jing Yang
10. Fujun Luo

• Curated by eLife

  eLife Assessment

  This valuable study by Xu and colleagues investigates brainstem circuits mediating evoked respiratory reflexes that they define as cough-like in a freely behaving mouse model. They have applied multiple circuit mapping and manipulation approaches to suggest that the caudal spinal trigeminal nucleus (SP5C) nucleus can play a novel role in generating a reflex cough-like behavior in mice. The authors give incomplete evidence that the reflex behavior produced in their mouse model is definitively cough, limiting functional interpretation of the putative circuit identified and requiring more thorough experimental interrogation of the behavior studied.

Reviewed by eLife

Dynamic changes in subplate and cortical plate microstructure at the onset of cortical folding in vivo

1. Siân Wilson
2. Daan Christiaens
3. Hyukjin Yun
4. Alena Uus
5. Lucilio Cordero-Grande
6. Vyacheslav Karolis
7. Anthony Price
8. Maria Deprez
9. Jacques-Donald Tournier
10. Mary Rutherford
11. Ellen Grant
12. Joseph V Hajnal
13. A David Edwards
14. Tomoki Arichi
15. Jonathan O’Muircheartaigh
16. Kiho Im

• Curated by eLife

  eLife Assessment

  This study presents a valuable study of early brain development using advanced MRI methods. In particular, the study investigates the relationship between the maturation of diffusion MRI tissue properties and suggests that they may precede and guide the emergence of brain folding patterns. The data is solid, however, the evidence supporting the precedence of tissue changes over brain folding appears incomplete.

Reviewed by eLife

Nonlinear brain connectivity from neurons to networks: quantification, sources and localization

1. Giulio Tani Raffaelli
2. Stanislav Jiříček
3. Jaroslav Hlinka

Reviewed by PREreview

Inverted encoding of neural responses to audiovisual stimuli reveals super-additive multisensory enhancement

1. Zak Buhmann
2. Amanda K Robinson
3. Jason B Mattingley
4. Reuben Rideaux

• Curated by eLife

  eLife Assessment

  Despite the well-established facilitatory effects of multisensory integration on behavioural measures, standard neuroimaging approaches have yet to reliably and precisely identify the corresponding neural correlates. In this valuable paper, Buhmann et al. leverage EEG decoding methods, moving beyond traditional univariate analyses, to capture these correlates. They present solid evidence that this approach can effectively estimate multisensory integration in humans across a broad range of contexts.

Reviewed by eLife

It’s the Sound, not the Pulse: Peripheral Magnetic Stimulation Reduces Central Sensitization through Auditory Modulatory Effects

1. Spencer S Abssy
2. Natalie R Osborne
3. Evgeny E Osokin
4. Rossi Tomin
5. Liat Honigman
6. James S Khan
7. Nathaniel W De Vera
8. Andrew Furman
9. Ali Mazaheri
10. David A Seminowicz
11. Massieh Moayedi

• Curated by eLife

  eLife Assessment

  Abssy et al. carried out a study to test the effects of repetitive peripheral magnetic stimulation (rPMS) on pain perception in an experimental pain model and concluded that the analgesic properties of rPMS could be largely attributed to its auditory component rather than peripheral nerve stimulation per se. While the study presents valuable data on the modulation of pain perception in response to the stimulation paradigms that were tested, several issues in the experimental design and interpretation of results render the evidence incomplete to support their main claims, which should therefore be revised. In that case, these results could be of interest to pain clinicians and researchers.

Reviewed by eLife

Investigating Mechanically Activated Currents from Trigeminal Neurons of Nonhuman Primates

1. Karen A. Lindquist
2. Jennifer M. Mecklenburg
3. Anahit H. Hovhannisyan
4. Shivani B. Ruparel
5. RE-JOIN Consortium Investigators
6. Armen N. Akopian

Reviewed by preLights

Platelet-derived LPA16:0 inhibits adult neurogenesis and stress resilience in anxiety disorder

1. Thomas Larrieu
2. Charline Carron
3. Fabio Grieco
4. Crystal Weber
5. Kyllian Ginggen
6. Aurélie Delacrétaz
7. Hector Gallart-Ayala
8. Mumeko Tsuda
9. Heather A. Cameron
10. Chin B. Eap
11. Julijana Ivanisevic
12. Pierre Magistretti
13. Ludovic Telley
14. Alexandre Dayer
15. Camille Piguet
16. Nicolas Toni

Reviewed by preLights

Neuronal activity inhibits axonal mitochondrial transport in a region-specific manner

1. Venneman Tom
2. Pieter Vanden Berghe

Reviewed by PREreview

Long-range neuropeptide relay as a central-peripheral communication mechanism for the context-dependent modulation of interval timing behaviors

1. Tianmu Zhang
2. Zekun Wu
3. Yutong Song
4. Wenjing Li
5. Yanying Sun
6. Xiaoli Zhang
7. Kyle Wong
8. Justine Schweizer
9. Khoi-Nguyen Ha Nguyen
10. Alex Kwan
11. Woo Jae Kim

Reviewed by Review Commons