Neuroscience

How do infant brains fold? Sulcal deepening is linked to development of sulcal span, thickness, curvature, and microstructure

1. Sarah S. Tung
2. Xiaoqian Yan
3. Bella Fascendini
4. Christina Tyagi
5. Charleny Martinez Reyes
6. Keithan Ducre
7. Karla Perez
8. Ahmad Allen
9. Juliet Horenziak
10. Hua Wu
11. Boris Keil
12. Vaidehi S. Natu
13. Kalanit Grill-Spector

Reviewed by preLights

Progressive neural engagement within the IFG-pMTG circuit as gesture and speech entropy and MI advances

1. Wanying Zhao
2. Zhouyi Li
3. Xiang Li
4. Yi Du

• Curated by eLife

  eLife Assessment

  This useful study uses brain stimulation and electroencephalography to study speech-gesture integration. It investigates the role of frontotemporal regions in integrating linguistic and extra-linguistic information during communication, focusing on the inferior frontal gyrus and posterior middle temporal gyrus. Reliance on activation patterns of tightly-coupled brain regions over short timescales leads to incomplete support for the study's conclusions due to conceptual and methodological limitations.

Reviewed by eLife

PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation

1. Shiyi Wang
2. Ryan Baumert
3. Gabrielle Séjourné
4. Dhanesh Sivadasan Bindu
5. Kylie Dimond
6. Kristina Sakers
7. Leslie Vazquez
8. Jessica L Moore
9. Christabel Xin Tan
10. Tetsuya Takano
11. Maria Pia Rodriguez
12. Nick Brose
13. Luke Bradley
14. Reed Lessing
15. Scott H Soderling
16. Albert R La Spada
17. Cagla Eroglu

• Curated by eLife

  eLife Assessment

  This study identifies astrocyte-intrinsic mechanisms by which the LRRK2 G2019S, a mutation linked to familial Parkinson's disease, disrupts synaptic integrity in the anterior cingulate cortex. The findings are convincing, as they rely on a comprehensive set of in vivo and in vitro genetic, biochemical, proteomic, and electrophysiological approaches. They are important because of their translational value, being validated in both mouse models and post-mortem human samples.

Reviewed by eLife

A Drosophila screen of schizophrenia-related genes highlights the requirement of neural and glial matrix metalloproteinases for neuronal remodeling

1. Shir Keret
2. Hagar Meltzer
3. Neta Marmor-Kollet
4. Oren Schuldiner

Reviewed by Review Commons