Neuroscience

Unveiling distinct neuroimmune responses in mouse models of cervical spinal cord injury: Hemisection versus hemicontusion

1. Wei Chen
2. Lucille Adam
3. Pauline Michel-Flutot
4. Arnaud Mansart
5. Stéphane Vinit
6. Isabelle Vivodtzev

Reviewed by Arcadia Science

Separable global and local beta burst dynamics in motor cortex of primates

1. Preeya Khanna
2. Behraz Farrokhi
3. Hoseok Choi
4. Sandon Griffin
5. Ian Heimbuch
6. Lisa Novik
7. Katherina Thiesen
8. John Morrison
9. Robert J Morecraft
10. Karunesh Ganguly

• Curated by eLife

  eLife Assessment

  This important study investigates changes in oscillatory activity across cortical and subcortical areas during stroke recovery in a nonhuman primate model. The authors distinguish between global and local oscillatory bursts, providing solid evidence that these two types of bursts correlate with distinct aspects of movement; additionally, they show that the likelihood of these bursts occurring follows opposing trends during recovery. The study could be further improved by accounting for inter-individual differences and by some technical improvements, such as employing more robust burst detection methods and more stringent analyses.

Reviewed by eLife

An evolutionarily conserved scheme for reformatting odor concentration in early olfactory circuits

1. Yang Shen
2. Arkarup Banerjee
3. Dinu F Albeanu
4. Saket Navlakha

• Curated by eLife

  eLife Assessment

  This is a valuable computational study of odor responses in the early olfactory system of insects and vertebrates. The study addresses the question of how information about odor concentration is encoded by second-order neurons in the invertebrate and vertebrate olfactory system; it offers insights into the transformation of neural signals from receptors to second-order neurons. While reanalysis of published data presents solid evidence supporting compression of concentration information, incomplete analysis is provided to resolve how this observation could be reconciled with the need to preserve information about changes in stimulus intensity. This work will be of interest to neuroscientists studying sensory processing broadly and olfaction specifically.

Reviewed by eLife

Astrocytic connexin43 phosphorylation contributes to seizure susceptibility after mild traumatic brain injury

1. Carmen Muñoz-Ballester
2. Owen Leitzel
3. Samantha Golf
4. Chelsea M Phillips
5. Michael J Zeitz
6. Rahul Pandit
7. Elizabeth Wash
8. Jenna V. Donohue
9. James W. Smyth
10. Samy Lamouille
11. Stefanie Robel

Reviewed by Review Commons

Working memory shapes neural geometry in human EEG over learning

1. Michał J Wójcik
2. Amy Li
3. Dante Wasmuht
4. Jake P Stroud
5. Mark G Stokes
6. Nicholas E Myers
7. Laurence T Hunt

• Curated by eLife

  eLife Assessment

  The findings are valuable, given that they highlight the flexible and future-oriented nature of working memory. However, the evidence for the claims about context/color generalization, behavioural relevance of context decoding, dimensionality reduction, neural geometry, the XOR representation, and the specific contribution of working memory is incomplete. The work could be reframed in terms of prospective remapping.

Reviewed by eLife

The C. elegans gustatory receptor homolog LITE-1 is a chemoreceptor required for diacetyl avoidance

1. Alan Koh
2. Eduard Bokman
3. Alexey Gavrikov
4. Javier Rodriguez
5. Changchun Chen
6. Alon Zaslaver
7. André EX Brown

• Curated by eLife

  eLife Assessment

  Avoidance of UV and blue light by the nematode C. elegans is mediated by the unusual transmembrane protein LITE-1, a non-canonical photoreceptor. In this valuable work, the authors report the surprising finding that LITE-1 function is also required for avoidance of very high concentrations of the food-associated odorant diacetyl. Although no molecular evidence is provided, the paper reports convincing studies indicating that LITE-1 can serve as a chemoreceptor for very high concentrations of diacetyl, adding an unexpected layer of complexity to the function of this unusual protein.

Reviewed by eLife