Neuroscience

Early Metabolic Alterations in Cerebrospinal Fluid Fatty Acid Profiles Linked to Cognitive Decline and All-Cause Dementia

1. Jacob Apibilla Ayembilla
2. Yannick N. Wadop
3. Rebecca Bernal
4. Biniyam A. Ayele
5. Murali Sargurupremraj
6. Xueqiu Jian
7. Alfred K. Njamnshi
8. Sudha Seshadri
9. Alice B. S. Nono Djotsa
10. Jayandra Jung Himali
11. Bernard Fongang
12. Alfred Fonteh

Reviewed by PREreview

Astrocytes mobilize a broader repertoire of lysosomal repair mechanisms than neurons

1. Erin M. Smith
2. Natali L. Chanaday
3. Sandra Maday

Reviewed by Arcadia Science

Selective life-long suppression of an odor processing channel in response to critical period experience

1. Hans C Leier
2. Julius Jonaitis
3. Alexander J Foden
4. Abigail J Wilkov
5. Annika E Ross
6. Paola Van der Linden Costello
7. Heather T Broihier
8. Andrew M Dacks

• Curated by eLife

  eLife Assessment

  This study in the Drosophila antennal lobe, which contains multiple non-equivalent sensory channels, provides valuable new insight into how early-life sensory experience can produce lasting, cell-type-specific changes in neural circuit function. The work convincingly demonstrates that glial-mediated pruning during a defined developmental window leads to persistent suppression of odor responses in one olfactory neuron type, while sparing another. The evidence is solid and supported by multiple complementary approaches, although some mechanistic interpretations remain speculative and would benefit from additional functional testing.

Reviewed by eLife

Enhancing Statistical Power While Maintaining Small Sample Sizes in Behavioral Neuroscience Experiments Evaluating Success Rates

1. Theo Desachy
2. Marc Thevenet
3. Samuel Garcia
4. Anistasha Lightning
5. Anne Didier
6. Nathalie Mandairon
7. Nicola Kuczewski

Reviewed by Peer Community in Neuroscience