Neuroscience

Fetal brain response to maternal inflammation requires microglia

1. Bridget Elaine LaMonica Ostrem
2. Nuria Dominguez Iturza
3. Jeffrey Stogsdill
4. Tyler Faits
5. Kwanho Kim
6. Joshua Z. Levin
7. Paola Arlotta

Reviewed by preLights

Psychological stress disturbs bone metabolism via miR-335-3p/Fos signaling in osteoclast

1. Jiayao Zhang
2. Juan Li
3. Jiehong Huang
4. Xuerui Xiang
5. Ruoyu Li
6. Yun Zhai
7. Shuxian Lin
8. Weicai Liu

• Curated by eLife

  eLife assessment

  The manuscript presents potentially valuable findings of bone remodeling by chronic unpredictable mild stress (CUMS). This is an interesting topic on mental stress on bone health and osteoporosis, and the authors offer solid evidence of decreased bone mass by micro-CT. However, to strengthen the work, the validation should be conducted in vivo, and the mechanism behind this should be investigated further.

Reviewed by eLife

Neural representations of predicted events: Evidence from time-resolved EEG decoding

1. Ai-Su Li
2. Jan Theeuwes
3. Dirk van Moorselaar

• Curated by eLife

  eLife assessment

  This valuable study investigates how a predicted - but not presented - stimulus within a sequence is represented in the brain using time-resolved EEG decoding. The results demonstrate that when the predicted stimulus is omitted, it is still represented at the expected space and time, although at present they provide only incomplete support given some alternative explanations. The findings will have implications for researchers across domains who are interested in learning and perception.

Reviewed by eLife

The NeuroML ecosystem for standardized multi-scale modeling in neuroscience

1. Ankur Sinha
2. Padraig Gleeson
3. Bóris Marin
4. Salvador Dura-Bernal
5. Sotirios Panagiotou
6. Sharon Crook
7. Matteo Cantarelli
8. Robert C. Cannon
9. Andrew P. Davison
10. Harsha Gurnani
11. R. Angus Silver

• Curated by eLife

  eLife assessment

  This important work presents a consolidated overview of the NeuroML2 open community standard. It provides convincing evidence for its central role within a broader comprehensive software ecosystem for the development of neuronal models that are open, shareable, reproducible, and interoperable. A major strength of the presented work is the persistence of the development over more than two decades to establish, maintain, and adapt this standard to meet the evolving needs of the field. This work is of broad interest to the sub-cellular, cellular, computational, and systems neuroscience communities undertaking studies involving theory, modeling, and simulation.

Reviewed by eLife

Does early-stage Alzheimer’s disease affect the dynamics of motor adaptation?

1. K Sutter
2. Wijdenes L Oostwoud
3. RJ van Beers
4. JAHR Claassen
5. RPC Kessels
6. WP Medendorp

Reviewed by PREreview

Cell-autonomous role of leucine-rich repeat kinase in the protection of dopaminergic neuron survival

1. Jongkyun Kang
2. Guodong Huang
3. Long Ma
4. Youren Tong
5. Anu Shahapal
6. Phoenix Chen
7. Jie Shen

• Curated by eLife

  eLife assessment

  This current revision builds on observations in validated conditional double KO (cDKO) mice for LRRK1 and LRRK2 that will be useful for the field, given that LRRK2 is widely expressed in the brain and periphery, and many divergent phenotypes have been attributed previously to LRRK2 expression. The manuscript presents solid data demonstrating that it is the loss of LRRK1 and LRRK2 expression within the SNpc DA cells that is not well tolerated, as it was previously unclear from past work whether neurodegeneration in the LRRK double Knock Out (DKO) was cell autonomous or the result of loss of LRRK1/LRRK2 expression in other types of cells. Future studies may pursue the biochemical mechanisms underlying the reason for the apoptotic cells noted in this study, as here, the LRRK1/LRRK2 KO mice did not replicate the dramatic increase in autophagic vacuole numbers previously noted in the germline global LRRK1/LRRK2 KO mice.

Reviewed by eLife

Short-term social isolation acts on hypothalamic neurons to promote social behavior in a sex- and context-dependent manner

1. Xin Zhao
2. Yurim Chae
3. Destiny Smith
4. Valerie Chen
5. Dylan DeFelipe
6. Joshua W Sokol
7. Archana Sadangi
8. Katherine Tschida

• Curated by eLife

  eLife assessment

  This useful study has identified a subset of neurons in the preoptic hypothalamus that promote social behavior in single-housed female mice. The approach is solid; however, due to a lack of significance in the key findings and competing outcomes between different manipulation methods, the evidence is incomplete. The authors have the potential to demonstrate evidence by either increasing the number of experimental animals represented in the study or by adjusting the language in the conclusions to reflect the findings.

Reviewed by eLife

Cell non-autonomous signaling through the conserved C. elegans glycopeptide hormone receptor FSHR-1 regulates cholinergic neurotransmission

1. Morgan Buckley
2. William P. Jacob
3. Letitia Bortey
4. Makenzi McClain
5. Alyssa L. Ritter
6. Amy Godfrey
7. Allyson S. Munneke
8. Shankar Ramachandran
9. Signe Kenis
10. Julie C. Kolnik
11. Sarah Olofsson
12. Ryan Adkins
13. Tanner Kutoloski
14. Lillian Rademacher
15. Olivia Heinecke
16. Alexandra Alva
17. Isabel Beets
18. Michael M. Francis
19. Jennifer R. Kowalski

Reviewed by Review Commons

The Switchmaze: an open-design device for measuring motivation and drive switching in mice

1. Clara Hartmann
2. Ambika Mahajan
3. Vinicius Borges
4. Lotte Razenberg
5. Yves Thönnes
6. Mahesh Miikael Karnani

Reviewed by Peer Community in Neuroscience

Adult neurogenesis through glial transdifferentiation in a CNS injury paradigm

1. Sergio Casas-Tintó
2. Nuria García-Guillen
3. Maria Losada-Pérez

• Curated by eLife

  eLife assessment

  In this work, the authors use a Drosophila adult ventral nerve cord injury model extending and confirming previous observations; this important study reveals key aspects of adult neural plasticity. Taking advantage of several genetic reporter and fate tracing tools, the authors provide solid evidence for different forms of glial plasticity, that are increased upon injury. The data on detected plasticity under physiologic conditions and especially the extent of cell divisions and cell fate changes upon injury would benefit from validation by additional markers. The experimental part would improve if strengthened and accompanied by a more comprehensive integration of results regarding glial reactivity in the adult CNS.

Reviewed by eLife