Neuroscience

Inverted encoding of neural responses to audiovisual stimuli reveals super-additive multisensory enhancement

1. Zak Buhmann
2. Amanda K Robinson
3. Jason B Mattingley
4. Reuben Rideaux

• Curated by eLife

  eLife Assessment

  Despite the well-established facilitatory effects of multisensory integration on behavioural measures, standard neuroimaging approaches have yet to reliably and precisely identify the corresponding neural correlates. In this valuable paper, Buhmann et al. leverage EEG decoding methods, moving beyond traditional univariate analyses, to capture these correlates. They present solid evidence that this approach can effectively estimate multisensory integration in humans across a broad range of contexts.

Reviewed by eLife

It’s the Sound, not the Pulse: Peripheral Magnetic Stimulation Reduces Central Sensitization through Auditory Modulatory Effects

1. Spencer S Abssy
2. Natalie R Osborne
3. Evgeny E Osokin
4. Rossi Tomin
5. Liat Honigman
6. James S Khan
7. Nathaniel W De Vera
8. Andrew Furman
9. Ali Mazaheri
10. David A Seminowicz
11. Massieh Moayedi

• Curated by eLife

  eLife Assessment

  Abssy et al. carried out a study to test the effects of repetitive peripheral magnetic stimulation (rPMS) on pain perception in an experimental pain model and concluded that the analgesic properties of rPMS could be largely attributed to its auditory component rather than peripheral nerve stimulation per se. While the study presents valuable data on the modulation of pain perception in response to the stimulation paradigms that were tested, several issues in the experimental design and interpretation of results render the evidence incomplete to support their main claims, which should therefore be revised. In that case, these results could be of interest to pain clinicians and researchers.

Reviewed by eLife

Investigating Mechanically Activated Currents from Trigeminal Neurons of Nonhuman Primates

1. Karen A. Lindquist
2. Jennifer M. Mecklenburg
3. Anahit H. Hovhannisyan
4. Shivani B. Ruparel
5. RE-JOIN Consortium Investigators
6. Armen N. Akopian

Reviewed by preLights

Platelet-derived LPA16:0 inhibits adult neurogenesis and stress resilience in anxiety disorder

1. Thomas Larrieu
2. Charline Carron
3. Fabio Grieco
4. Crystal Weber
5. Kyllian Ginggen
6. Aurélie Delacrétaz
7. Hector Gallart-Ayala
8. Mumeko Tsuda
9. Heather A. Cameron
10. Chin B. Eap
11. Julijana Ivanisevic
12. Pierre Magistretti
13. Ludovic Telley
14. Alexandre Dayer
15. Camille Piguet
16. Nicolas Toni

Reviewed by preLights

On-Demand Seizures Facilitate Rapid Screening of Therapeutics for Epilepsy

1. Yuzhang Chen
2. Brian Litt
3. Flavia Vitale
4. Hajime Takano

• Curated by eLife

  eLife Assessment

  The authors modified a common method to induce epilepsy in mice to provide an improved approach to screen new drugs for epilepsy. This is important because of the need to develop new drugs for patients who are refractory to current medications. The authors' method evokes seizures to circumvent a low rate of spontaneous seizures and the approach was validated using two common anti-seizure medications. The strength of evidence was solid, making the study invaluable, but there were some limitations to the approach and methods.

Reviewed by eLife

Neuronal activity inhibits axonal mitochondrial transport in a region-specific manner

1. Venneman Tom
2. Pieter Vanden Berghe

Reviewed by PREreview

Long-range neuropeptide relay as a central-peripheral communication mechanism for the context-dependent modulation of interval timing behaviors

1. Tianmu Zhang
2. Zekun Wu
3. Yutong Song
4. Wenjing Li
5. Yanying Sun
6. Xiaoli Zhang
7. Kyle Wong
8. Justine Schweizer
9. Khoi-Nguyen Ha Nguyen
10. Alex Kwan
11. Woo Jae Kim

Reviewed by Review Commons

Peptidergic neurons with extensive branching orchestrate the internal states and energy balance of male Drosophila melanogaster

1. Yutong Song
2. Tianmu Zhang
3. Xiaoli Zhang
4. Tae Hoon Ryu
5. Kyle Wong
6. Zekun Wu
7. Yanan Wei
8. Justine Schweizer
9. Khoi-Nguyen Ha Nguyen
10. Alex Kwan
11. Kweon Yu
12. Woo Jae Kim

Reviewed by Review Commons

Base editing of Ptbp1 in neurons alleviates symptoms in a mouse model of Parkinson’s disease

1. Desiree Böck
2. Maria Wilhelm
3. Jonas Mumenthaler
4. Daniel Fabio Carpanese
5. Peter I Kulcsár
6. Simon d'Aquin
7. Alessio Cremonesi
8. Anahita Rassi
9. Johannes Häberle
10. Tommaso Patriarchi
11. Gerald Schwank

• Curated by eLife

  eLife Assessment

  This is an important study suggesting that neuron-specific loss of function of the RNA splicing factor Ptbp1 in striatal neurons induces dopaminergic markers and alleviates motor defects in a 6-hydroxydopamine (6-OHDA) mouse model of Parkinson's Disease. The evidence supporting the rescue of motor deficits following Ptbp1 manipulation is solid, and, while additional characterization of dopaminergic neuronal identity may be required in future studies, these results have clear implications for Parkinson's disease therapeutics. The study also addresses recent controversial literature on cell reprogramming in Parkinson's Disease and will be of interest to researchers with a focus on the application of gene therapy to rescue neurodegeneration.

Reviewed by eLife

GnRH pulse generator activity in mouse models of polycystic ovary syndrome

1. Ziyue Zhou
2. Su Young Han
3. Maria Pardo-Navarro
4. Ellen G Wall
5. Reena Desai
6. Szilvia Vas
7. David J Handelsman
8. Allan E Herbison

• Curated by eLife

  eLife Assessment

  This important study reports findings on the GnRH pulse generator's role in androgen-exposed mouse models, providing further insights into PCOS pathophysiology and advancing the field of reproductive endocrinology. The experimental data were collected using cutting-edge methodologies and are solid. The findings, while interesting, are primarily applicable to mouse models, and their translation to human physiology requires cautious interpretation and further validation. This work will be of interest to endocrinologists and reproductive biologists.

Reviewed by eLife