Neuroscience

Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration

1. Erin M Ritchie
2. Dilan Acar
3. Siming Zhong
4. Qianyi Pu
5. Yunbo Li
6. Binhai Zheng
7. Yishi Jin

• Curated by eLife

  eLife Assessment

  This manuscript describes the impact of modulating signaling by a key regulatory enzyme, Dual Leucine Zipper Kinase (DLK), on hippocampal neurons. The results are interesting and will be important for scientists interested in synapse formation, axon specification, and cell death. The authors have carefully addressed the comments made by the reviewers and the findings are convincing in large part due to the use of extensive mouse genetics, detailed gene expression of enriched genes, and recognition of neuron vulnerability.

Reviewed by eLife

Enteric glia regulate Paneth cell secretion and intestinal microbial ecology

1. Aleksandra Prochera
2. Anoohya N Muppirala
3. Gavin A Kuziel
4. Salima Soualhi
5. Amy Shepherd
6. Liang Sun
7. Biju Issac
8. Harry J Rosenberg
9. Farah Karim
10. Kristina Perez
11. Kyle H Smith
12. Tonora H Archibald
13. Seth Rakoff-Nahoum
14. Susan J Hagen
15. Meenakshi Rao

• Curated by eLife

  eLife Assessment

  This study presents important findings on the function of enteric glia expressing proteolipid protein 1 (PLP1+ glia). The evidence supporting the claims of the authors is solid, although the inclusion of additional data showing the mechanisms by which PLP1+ enteric glia acts on Paneth cells would have strengthened the study. The work will be of interest to colleagues studying intestinal biology.

Reviewed by eLife

Increased reluctant vesicles underlie synaptic depression by GPR55 in axon terminals of cerebellar Purkinje cells

1. Takuma Inoshita
2. Shin-ya Kawaguchi

• Curated by eLife

  eLife Assessment

  This is an important study reporting that activation of the presynaptic GPR55 receptor suppresses synaptic transmission by modulating GABA release through the reduction of the readily releasable pool without affecting the presynaptic AP waveform and calcium influx. The evidence supporting this claim is compelling and based on an impressive array of techniques including patch-clamp recordings from the axon terminals of cerebellar Purkinje cells and fluorescent imaging of vesicular exocytosis. However, a few technical issues leave some questions open, these include uncertainty regarding the specificity of pharmacological agents and the nature of the endogenous process that would activate this pathway in vivo. In the current form, the evidence indicating that synaptic vesicles become insensitive to VGCC activation in the presence of GPR55 is weak and would need to be supported with additional experimental data.

Reviewed by eLife

Combined transcriptomic, connectivity, and activity profiling of the medial amygdala using highly amplified multiplexed in situ hybridization (hamFISH)

1. Mathew D Edwards
2. Ziwei Yin
3. Risa Sueda
4. Alina Gubanova
5. Chang S Xu
6. Virág Lakner
7. Megan Murchie
8. Chi-Yu Lee
9. Kristal Ng
10. Karolina Farrell
11. Rupert Faraway
12. Subham Ganguly
13. Elina Jacobs
14. Bogdan Bintu
15. Yoh Isogai

• Curated by eLife

  eLife Assessment

  Overall, this is an important work: the new methodology of hamFISH is a key additional tool for the assessment of the expression of multiple genes simultaneously. The authors provide convincing evidence of the utility of this approach on Medial Amygdala (MeA) tissue leveraging previous a transcriptomic dataset for gene selection. The authors also present a deeper dive into putative relationships between the on-tissue expression of subsets of genes and connectivity and behavioral regulation. The putative biological insights are intriguing, although preliminary, but notably they set up questions for future studies.

Reviewed by eLife

Visually-guided compensation of deafening-induced song deterioration

1. Manon Rolland
2. Anja T. Zai
3. Richard H. R. Hahnloser
4. Catherine Del Negro
5. Nicolas Giret

Reviewed by preLights

Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part II: Physiology and Experimentation

1. James B Isbister
2. András Ecker
3. Christoph Pokorny
4. Sirio Bolaños-Puchet
5. Daniela Egas Santander
6. Alexis Arnaudon
7. Omar Awile
8. Natali Barros-Zulaica
9. Jorge Blanco Alonso
10. Elvis Boci
11. Giuseppe Chindemi
12. Jean-Denis Courcol
13. Tanguy Damart
14. Thomas Delemontex
15. Alexander Dietz
16. Gianluca Ficarelli
17. Mike Gevaert
18. Joni Herttuainen
19. Genrich Ivaska
20. Weina Ji
21. Daniel Keller
22. James King
23. Pramod Kumbhar
24. Samuel Lapere
25. Polina Litvak
26. Darshan Mandge
27. Eilif B Muller
28. Fernando Pereira
29. Judit Planas
30. Rajnish Ranjan
31. Maria Reva
32. Armando Romani
33. Christian Rössert
34. Felix Schürmann
35. Vishal Sood
36. Aleksandra Teska
37. Anil Tuncel
38. Werner Van Geit
39. Matthias Wolf
40. Henry Markram
41. Srikanth Ramaswamy
42. Michael W Reimann

• Curated by eLife

  eLife Assessment

  This study reports a model of 8 somatosensory areas of the rat cortex consisting of 4.2 million morphologically and electrically detailed neurons. The authors carry out simulation experiments aimed at understanding how multiscale organization of the cortical network shapes neural activity. While the reviewers found the results to be solid, they note that they could have likely been obtained using a much smaller portion of the model. Nonetheless, the release of the modeling platform represents a significant contribution to the field by providing a valuable resource for the scientific community.

Reviewed by eLife

Robust variability of grid cell properties within individual grid modules enhances encoding of local space

1. William T Redman
2. Santiago Acosta-Mendoza
3. Xue-Xin Wei
4. Michael J Goard

• Curated by eLife

  eLife Assessment

  This valuable study examines the variability in spacing and direction of entorhinal grid cells, providing convincing evidence that such variability helps disambiguate locations within an environment. This study will be of interest to neuroscientists working on spatial navigation and, more broadly, on neural coding.

Reviewed by eLife

Chronic RNA G-quadruplex accumulation in aging and Alzheimer’s disease

1. Lena Kallweit
2. Eric Daniel Hamlett
3. Hannah Saternos
4. Anah Gilmore
5. Ann-Charlotte Granholm
6. Scott Horowitz

• Curated by eLife

  eLife Assessment

  The current human tissue-based study provides compelling evidence correlating hippocampal expressions of RNA guanine-rich G-quadruplexes with aging and with Alzheimer's Disease presence and severity. The results are fundamental and will rejuvenate our understanding of aging and AD's pathogenesis.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife, Review Commons

Rate of brain aging associates with future executive function in Asian children and older adults

1. Susan F Cheng
2. Wan Lin Yue
3. Kwun Kei Ng
4. Xing Qian
5. Siwei Liu
6. Trevor WK Tan
7. Kim-Ngan Nguyen
8. Ruth LF Leong
9. Saima Hilal
10. Ching-Yu Cheng
11. Ai Peng Tan
12. Evelyn C Law
13. Peter D Gluckman
14. Christopher Li-Hsian Chen
15. Yap Seng Chong
16. Michael J Meaney
17. Michael WL Chee
18. BT Thomas Yeo
19. Juan Helen Zhou

• Curated by eLife

  eLife Assessment

  This valuable study marks a significant advancement in brain aging research by centering on Asian populations (Chinese, Malay, and Indian Singaporeans), a group frequently underrepresented in such studies. It unveils solid evidence for anatomical differences in brain aging predictors between the young and old age groups. Overall, this study broadens our understanding of brain aging across diverse ethnicities.

Reviewed by eLife

How relevant is the prior? Bayesian causal inference for dynamic perception in volatile environments

1. David Meijer
2. Roberto Barumerli
3. Robert Baumgartner

• Curated by eLife

  eLife Assessment

  This study makes a valuable contribution to understanding Bayesian inference in dynamic environments by demonstrating how humans integrate prior beliefs with sensory evidence, revealing an overestimation of environmental volatility while accurately tracking noise. The evidence is solid, supported by robust model fitting and principled factorial model set analyses, though limitations in sample size and inconclusive findings on memory capacity tradeoffs reduce the overall impact. Future work should expand validation across datasets, enhance model comparisons, and explore the generalizability of reduced Bayesian frameworks to strengthen the conclusions and broader relevance of the study.

Reviewed by eLife