Neuroscience

Distributed neural computation and the evolution of the first brains

1. Vikram Chandra
2. Mehrana R. Nejad
3. Allison P. Kann
4. Ananya Salem
5. Karl A.P. Hill
6. Richard Schalek
7. Jeff Lichtman
8. L. Mahadevan
9. Mansi Srivastava

Reviewed by PREreview

Spatial learning in multi-scale environments: Roles of hippocampus, orbitofrontal cortex, and retrosplenial cortex

1. Yidan Qiu
2. Senning Zheng
3. Huakang Li
4. Shuting Lin
5. Ruiwang Huang

• Curated by eLife

  eLife Assessment

  The goal of this useful study is to examine learning-related changes in neural representations of global and local spatial reference frames in a spatial navigation task. Although the study addresses an interesting question, the evidence for neural representations in the hippocampus and retrosplenial cortex remains incomplete because of confounds in the experimental design and partial data analysis. There are further concerns about the framing of the study in the context of the relevant literature as well as the discussion.

Reviewed by eLife

Synergistic MAPT mutations as a platform to uncover modifiers of tau pathogenesis

1. Miles R Bryan
2. Michael F Almeida
3. Kyle Pellegrino
4. Carli K Opland
5. J Ethan Paulakonis
6. Jake McGillion-Moore
7. Hanna Trzeciakiewicz
8. Diamond King
9. Xu Tian
10. Jui-Heng Tseng
11. Jonathan C Schisler
12. Nicholas G Brown
13. Ben A Bahr
14. Todd J Cohen

• Curated by eLife

  eLife Assessment

  This study presents compelling new data that combine two FTD-tau mutations, P301L/S320F (PL-SF), that reliably induce spontaneous full-length tau aggregation across multiple cellular systems. The findings are important for the field of neurodegenerative disease. The strength of evidence is solid; however, several conclusions would benefit from more validation.

Reviewed by eLife

A neuropeptide-specific signaling pathway for state-dependent regulation of the mesolimbic dopamine system

1. Mollie X. Bernstein
2. Omar Koita
3. Marta Trzeciak
4. Andrew Fan
5. Daniel T. McAuley
6. Seung-Woo Jin
7. Larry S. Zweifel

Reviewed by PREreview

ATF4 activates a transcriptional program that chronically suppresses mTOR activity promoting neurodegeneration in Parkinson’s disease models

1. Matthew D. Demmings
2. Erica A. Kane
3. Elizabeth C. Tennyson
4. Kate Hurley
5. Joy Zhao
6. Nicholas A. Cruickshanks
7. Victoria Ciz
8. Jordan M. Krupa
9. Stephen H. Pasternak
10. Sean P. Cregan

Reviewed by PREreview