Neuroscience

Linking minimal and detailed models of CA1 microcircuits reveals how theta rhythms emerge and how their frequencies are controlled

1. Alexandra P Chatzikalymniou
2. Melisa Gumus
3. Anton R Lunyov
4. Scott Rich
5. Jeremie Lefebvre
6. Frances K Skinner

• Curated by eLife

  Summary: This study tackles a difficult problem of understanding the basis for hippocampal theta rhythms through reduction of a highly detailed model, seeking to validate a reduced model that would be more amenable to analysis. The reviewers appreciated the attention to this challenging problem and the substantial work that went into it, but had several fundamental concerns about the methodology, interpretation, and reporting.

Reviewed by eLife

Differential aberrant structural synaptic plasticity in axons and dendrites ahead of their degeneration in tauopathy

1. Johanna S. Jackson
2. James D. Johnson
3. Soraya Meftah
4. Tracey K Murray
5. Zeshan Ahmed
6. Matteo Fasiolo
7. Michael L. Hutton
8. John T.R. Isaac
9. Michael J. O’Neill
10. Michael C. Ashby

• Curated by eLife

  Summary: This paper describes studies of a mouse model of tauopathy with relevance to Alzheimer's Disease. A powerful approach of longitudinal imaging of single synaptic structures over time allows insights into the time course of progressive neurogenerative responses. The strengths of the report are the relevance of the question to human disease, the powerful imaging approach, and the indication that there may be a programmed sequence of structural changes that mediate tauopathy. On the other hand, there were multiple issues with the transgenic mouse model used, which would seriously limit interpretation of results without suitable controls. Further, the data set appeared to be quite noisy, and variable between animals, which may result in part from the nonspecific methods of expressing fluorescent markers, thus leading to uncertainty regarding the specific identity of pre- and post-synaptic elements.

Reviewed by eLife

Brain Network Reconfiguration for Narrative and Argumentative Thought

1. Yangwen Xu
2. Lorenzo Vignali
3. Olivier Collignon
4. Davide Crepaldi
5. Roberto Bottini

• Curated by eLife

  Summary: The reviewers thought this was a nicely written paper, and were interested in the idea of extending intersubject correlation (ISC) and intersubject functional connectivity (ISFC) work on narratives to arguments. One major concern was that effects reported here may be driven in part by the scrambled conditions. Specifically, the scrambled argument seems to have resulted in stronger and more widespread ISC than the intact argument: this would call into question assumptions about the scrambled version being a control condition. Another, related concern raised is that perhaps argumentative texts are very different from narrative texts: perhaps argumentative texts are less structured, or less interesting (?) and this is why the intact and scrambled versions are so similar. Together with other issues, relating to the interpretation of the findings, it was felt that while of interest, the study's major conclusions could not be justified without additional experiments.

Reviewed by eLife

Can computers understand words like humans do? Comparable semantic representation in neural and computer systems

1. Linmin Zhang
2. Lingting Wang
3. Jinbiao Yang
4. Peng Qian
5. Xuefei Wang
6. Xipeng Qiu
7. Zheng Zhang
8. Xing Tian

Reviewed by eLife

Evoked pain intensity representation is distributed across brain systems: A multistudy mega-analysis

1. Bogdan Petre
2. Philip Kragel
3. Lauren Y. Atlas
4. Stephan Geuter
5. Marieke Jepma
6. Leonie Koban
7. Anjali Krishnan
8. Marina Lopez-Sola
9. Mathieu Roy
10. Choong-Wan Woo
11. Tor D. Wager

Reviewed by eLife

Spinal lumbar dI2 interneurons contribute to stability of bipedal stepping

1. Baruch Haimson
2. Yoav Hadas
3. Nimrod Bernat
4. Artur Kania
5. Monica A Daley
6. Yuval Cinnamon
7. Aharon Lev-Tov
8. Avihu Klar

Reviewed by eLife

Neural signatures of vigilance decrements predict behavioural errors before they occur

1. Hamid Karimi-Rouzbahani
2. Alexandra Woolgar
3. Anina N. Rich

Reviewed by eLife

Timing matters: The temporal representation of experience in subjective mood reports

1. Hanna Keren
2. Charles Zheng
3. David C. Jangraw
4. Katharine Chang
5. Aria Vitale
6. Dylan Nielson
7. Robb B. Rutledge
8. Francisco Pereira
9. Argyris Stringaris

Reviewed by eLife

Post-mitotic Prox1 expression controls the final specification of cortical VIP interneuron subtypes

1. Tevye Jason Stachniak
2. Rahel Kastli
3. Olivia Hanley
4. Ali Özgür Argunsah
5. Theofanis Karayannis

Reviewed by eLife

Retinal optic flow during natural locomotion

1. Jonathan Samir Matthis
2. Karl S Muller
3. Kathryn Bonnen
4. Mary M Hayhoe

Reviewed by eLife