Neuroscience

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium

1. Fadi Jacob
2. Sarshan R. Pather
3. Wei-Kai Huang
4. Feng Zhang
5. Samuel Zheng Hao Wong
6. Haowen Zhou
7. Beatrice Cubitt
8. Wenqiang Fan
9. Catherine Z. Chen
10. Miao Xu
11. Manisha Pradhan
12. Daniel Y. Zhang
13. Wei Zheng
14. Anne G. Bang
15. Hongjun Song
16. Juan Carlos de la Torre
17. Guo-li Ming

Reviewed by ScreenIT

Disruption of nuclear architecture as a cause of COVID-19 induced anosmia

1. Marianna Zazhytska
2. Albana Kodra
3. Daisy A. Hoagland
4. John F. Fullard
5. Hani Shayya
6. Arina Omer
7. Stuart Firestein
8. Qizhi Gong
9. Peter D. Canoll
10. James E. Goldman
11. Panos Roussos
12. Benjamin R. tenOever
13. Jonathan B. Overdevest
14. Stavros Lomvardas

Reviewed by ScreenIT

Age-dependent appearance of SARS-CoV-2 entry sites in mouse chemosensory systems reflects COVID-19 anosmia-ageusia symptoms

1. Julien Brechbühl
2. Ana Catarina Lopes
3. Dean Wood
4. Sofiane Bouteiller
5. Aurélie de Vallière
6. Chantal Verdumo
7. Marie-Christine Broillet

Reviewed by ScreenIT

COVID-19–related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters

1. Guilherme Dias de Melo
2. Françoise Lazarini
3. Sylvain Levallois
4. Charlotte Hautefort
5. Vincent Michel
6. Florence Larrous
7. Benjamin Verillaud
8. Caroline Aparicio
9. Sebastien Wagner
10. Gilles Gheusi
11. Lauriane Kergoat
12. Etienne Kornobis
13. Flora Donati
14. Thomas Cokelaer
15. Rémi Hervochon
16. Yoann Madec
17. Emmanuel Roze
18. Dominique Salmon
19. Hervé Bourhy
20. Marc Lecuit
21. Pierre-Marie Lledo

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Expression of the ACE2 Virus Entry Protein in the Nervus Terminalis Reveals the Potential for an Alternative Route to Brain Infection in COVID-19

1. Katarzyna Bilinska
2. Christopher S. von Bartheld
3. Rafal Butowt

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Brain Inflammation and Intracellular α-Synuclein Aggregates in Macaques after SARS-CoV-2 Infection

1. Ingrid H. C. H. M. Philippens
2. Kinga P. Böszörményi
3. Jacqueline A. M. Wubben
4. Zahra C. Fagrouch
5. Nikki van Driel
6. Amber Q. Mayenburg
7. Diana Lozovagia
8. Eva Roos
9. Bernadette Schurink
10. Marianna Bugiani
11. Ronald E. Bontrop
12. Jinte Middeldorp
13. Willy M. Bogers
14. Lioe-Fee de Geus-Oei
15. Jan A. M. Langermans
16. Ernst J. Verschoor
17. Marieke A. Stammes
18. Babs E. Verstrepen

Reviewed by ScreenIT

SARS-CoV-2 binding to ACE2 triggers pericyte-mediated angiotensin-evoked cerebral capillary constriction

1. Chanawee Hirunpattarasilp
2. Gregory James
3. Felipe Freitas
4. Huma Sethi
5. Josef T. Kittler
6. Jiandong Huo
7. Raymond J. Owens
8. David Attwell

Reviewed by ScreenIT

Cortical entrainment to hierarchical contextual rhythms recomposes dynamic attending in visual perception

1. Peijun Yuan
2. Ruichen Hu
3. Xue Zhang
4. Ying Wang
5. Yi Jiang

• Curated by eLife

  Evaluation Summary:

  This study by Wang et al. used a series of carefully designed behavioral experiments to convincingly demonstrate that the attentional blink (AB) could be modulated by higher-order rhythmic regularity. EEG results further support the link between the elicited neural entrainment and the AB modulation effect. They propose that the rhythmic context implements a second-order temporal structure to the first-order regularities posited in dynamic attention theory.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Distinct protocerebral neuropils associated with attractive and aversive female-produced odorants in the male moth brain

1. Jonas Hansen Kymre
2. XiaoLan Liu
3. Elena Ian
4. Christoffer Nerland Berge
5. GuiRong Wang
6. Bente Gunnveig Berg
7. XinCheng Zhao
8. Xi Chu

• Curated by eLife

  Evaluation Summary:

  This study identifies and describes the functional properties of antennal lobe output neurons towards the response to pheromone odors in the moth brain. This paper will be of interest to neuroscientists investigating how sensory information is organized in the brain. Through a combination of technically challenging experiments, the paper identifies the brain regions that differentially process attractive vs aversive olfactory pheromone signals. While not an exhaustive data set, it provides compelling evidence for one model of how the moth brain interprets complex pheromone olfactory odors.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts

1. Jasbir Singh Dalal
2. Kellen Diamond Winden
3. Catherine Lourdes Salussolia
4. Maria Sundberg
5. Achint Singh
6. Truc Thanh Pham
7. Pingzhu Zhou
8. William T Pu
9. Meghan T Miller
10. Mustafa Sahin

• Curated by eLife

  Evaluation Summary:

  The main strength of the manuscript is the data sets generated by the cell type-specific RNA-seq and TRAP-seq in cerebellar PCs that lack Tsc1. In addition, the bioinformatic analysis revealed several interesting findings, including the observation that FMRP target RNAs are reduced in the Tsc1 mutant PCs and that the translational efficiency of these RNAs is actually increased, likely through compensatory mechanisms.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife