Neuroscience

Rescuing auditory temporal processing with a novel augmented acoustic environment in a mouse model of congenital SNHL

1. Adam C. Dziorny
2. Luisa L. Scott
3. Anne E. Luebke
4. Joseph P. Walton

• Curated by eLife

  Summary: The reviewer and the editors both recognize that the study suggests a clear improvement of auditory sensitivity, at least to gaps, with early temporal enrichment, and agree on the quality of the work performed. However, the improvements brought by the new paradigm are small and not supported by strong statistics. Overall also this study seems sound but too specialized for a broader readership.

Reviewed by eLife

Local projections of layer Vb-to-Va are more effective in lateral than in medial entorhinal cortex

1. Shinya Ohara
2. Stefan Blankvoort
3. Rajeevkumar R. Nair
4. Maximiliano J. Nigro
5. Eirik S. Nilssen
6. Clifford Kentros
7. Menno P. Witter

• Curated by eLife

  Summary: The study addresses a fundamentally important question regarding the connectivity of LVb and LVa in the medial and lateral entorhinal cortex. The authors suggest that LVb to LVa connection exists in the LEC but not in the MEC. This finding would have important implications on studies investigating circuits functions between the hippocampus and the EC. All three reviewers found the central question important and the data novel. However, there are several technical issues that limit the robustness of the authors claim.

  1. While the transgenic animal used in these experiments is elegant and novel, it only labels a subpopulation of the neurons. There is a possibility of selective labelling of neurons with distinct connectivity patterns. The authors would need to show that their approach is not leading to false negative results due to the selective visualization of those neurons that project more modestly to the LVa.

  2. The specificity of the injection to the LEC/MEC should be better documented and potential spread to the perirhinal or postrhinal cortex carefully excluded.

  3. The findings are presented as LVb to LVa connection did not exist at all in the MEC, however the data shows that the connection is there but it is significantly less dense than in the LEC. Given the graded finding, if the authors aim to show their central claim regarding the lack of mediation of hippocampo-cortical outputs by this connection in the MEC, this would require the addition of functional studies.

Reviewed by eLife

Axonal ER Ca ²⁺ Release Enhances Miniature, but Reduces Activity-Dependent Glutamate Release in a Huntington Disease Model

1. James P. Mackay
2. Amy I. Smith-Dijak
3. Ellen T. Koch
4. Peng Zhang
5. Evan Fung
6. Wissam B. Nassrallah
7. Caodu Buren
8. Mandi Schmidt
9. Michael R. Hayden
10. Lynn A. Raymond

Reviewed by eLife

Neonatal LPS exposure reduces ATP8A2 level in the prefrontal cortex in mice via increasing IFN-γ level

1. Jiapeng Deng
2. Linyang Song
3. Zhiqin Yang
4. Sixie Zheng
5. Zhuolin Du
6. Li Luo
7. Jing Liu
8. Xiaobao Jin
9. Junhua Yang

Reviewed by eLife

Responsiveness variability during anaesthesia relates to inherent differences in brain structure and function of the fronto-parietal networks

1. Feng Deng
2. Nicola Taylor
3. Adrian M. Owen
4. Rhodri Cusack
5. Lorina Naci

Reviewed by eLife

Spontaneous activity changes in large-scale cortical networks in older adults couple to distinct hemodynamic morphology

1. Tatiana Sitnikova
2. Jeremy W. Hughes
3. Casey M. Howard
4. Kimberly A. Stephens
5. Mark W. Woolrich
6. David H. Salat

Reviewed by eLife

Role of matrix metalloproteinase-9 in neurodevelopmental deficits and experience-dependent plasticity in Xenopus laevis

1. Sayali V Gore
2. Eric J James
3. Lin-chien Huang
4. Jenn J Park
5. Andrea Berghella
6. Adrian C Thompson
7. Hollis T Cline
8. Carlos D Aizenman

Reviewed by eLife

Sleep-learning Impairs Subsequent Awake-learning

1. Simon Ruch
2. Marc Alain Züst
3. Katharina Henke

Reviewed by eLife

Learning excitatory-inhibitory neuronal assemblies in recurrent networks

1. Owen Mackwood
2. Laura B. Naumann
3. Henning Sprekeler

Reviewed by eLife

Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech

1. Melissa J Polonenko
2. Ross K Maddox

• Curated by eLife

  Summary: This manuscript describes a type of alteration to speech to make it more peaky, with the goal of inducing stronger responses in the auditory brainstem. Recent work has employed naturalistic speech to investigate subcortical mechanisms of speech processing. However, previous methods were ill equipped to tease apart the neural responses in different parts of the brainstem. The authors show that their speech manipulation improves this: the peaky speech that they develop allows to segregate different waves of the brainstem response. This development may allow further and more refined investigations of the contribution of different parts of the brainstem to speech processing, as well as to hearing deficits.

Reviewed by eLife