Neuroscience

Age-associated changes to neuronal dynamics involve a disruption of excitatory/inhibitory balance in C. elegans

1. Gregory S Wirak
2. Jeremy Florman
3. Mark J Alkema
4. Christopher W Connor
5. Christopher V Gabel

• Curated by eLife

  Evaluation Summary:

  This study reports ageing associated decline in coordinated whole brain dynamics of the nematode C. elegans. It is interesting to a broad range of scientists studying neuronal circuit dynamics, the processes of ageing and neurodegenerative diseases. The work provides an impressive amount of whole brain imaging experiments and is the first single cell resolution whole brain imaging study in any organism that reports how whole brain dynamics change over the course of ageing.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Prefrontal cortex supports speech perception in listeners with cochlear implants

1. Arefeh Sherafati
2. Noel Dwyer
3. Aahana Bajracharya
4. Mahlega Samira Hassanpour
5. Adam T Eggebrecht
6. Jill B Firszt
7. Joseph P Culver
8. Jonathan E Peelle

• Curated by eLife

  Evaluation Summary:

  This work generates helpful new data on the network of brain areas employed for listening to speech in cochlear implant users. This is a difficult undertaking because functional MR is not possible in this group. The work uses a new type of near infrared spectroscopy to obtain measures related to brain activity in superficial areas and shows increased activity in frontal areas during speech perception.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Cd59 and inflammation regulate Schwann cell development

1. Ashtyn T Wiltbank
2. Emma R Steinson
3. Stacey J Criswell
4. Melanie Piller
5. Sarah Kucenas

• Curated by eLife

  Evaluation Summary:

  This paper by Wiltbank et al. "Cd59 and inflammation orchestrate Schwann cell development" investigates the function of the small GPI-anchored protein Cd59, a protein known to suppress complement mediated inflammation, in Schwann cell development and myelination, using zebrafish as a model system. This paper will be of broad interest to developmental biologists, glial biologists and immunologists, as it suggests the interesting and novel findings that Cd59 regulates Schwann cell development, mainly by modulating Schwann cell proliferation.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Predictions and experimental tests of a new biophysical model of the mammalian respiratory oscillator

1. Ryan S Phillips
2. Hidehiko Koizumi
3. Yaroslav I Molkov
4. Jonathan E Rubin
5. Jeffrey C Smith

• Curated by eLife

  Evaluation Summary:

  In this paper the authors test three hypotheses: 1) INap and ICAN blockade alter network excitability in the preBötC, the region of the brainstem that generates inspiratory breathing rhythm; 2) that INaP is essential for preBötC rhythmogenesis; 3) ICAN is essential for generating the amplitude of rhythmic output but not rhythm generation. They test these hypotheses using optogenetic manipulation of local preBötC excitability and the use of pharmacologic blockade of INaP and ICAN. This manuscript provides substantive evidence for the role of INaP in modulating breathing frequency and ICAN in altering amplitude with some interesting boundary conditions when ICAN and INaP are selectively blocked and tests predictions about these currents using computational simulation.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife

Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice

1. Vasiliki-Ilya Gargareta
2. Josefine Reuschenbach
3. Sophie B Siems
4. Ting Sun
5. Lars Piepkorn
6. Carolina Mangana
7. Erik Späte
8. Sandra Goebbels
9. Inge Huitinga
10. Wiebke Möbius
11. Klaus-Armin Nave
12. Olaf Jahn
13. Hauke B Werner

• Curated by eLife

  Evaluation Summary:

  In this impressive manuscript the authors study the similarities and differences between the molecules that comprise the insulation that surrounds human brain nerve fibers (myelin), providing essential insight into how to interpret studies of myelin, from the perspective of different species. In all, this manuscript provides a new resource that will be of interest to the myelin community as well as investigators examining the contributions of oligodendrocytes to human neurodegenerative disease.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

Reviewed by eLife

SARS-CoV-2 spike proteins uptake mediated by lipid raft ganglioside GM1 in human cerebrovascular cells

1. Conor McQuaid
2. Alexander Solorzano
3. Ian Dickerson
4. Rashid Deane

Reviewed by ScreenIT

Toward A Reproducible, Scalable Framework for Processing Large Neuroimaging Datasets

1. Erik C. Johnson
2. Miller Wilt
3. Luis M. Rodriguez
4. Raphael Norman-Tenazas
5. Corban Rivera
6. Nathan Drenkow
7. Dean Kleissas
8. Theodore J. LaGrow
9. Hannah Cowley
10. Joseph Downs
11. Jordan Matelsky
12. Marisa Hughes
13. Elizabeth Reilly
14. Brock Wester
15. Eva Dyer
16. Konrad Kording
17. William Gray-Roncal

Reviewed by GigaScience

A highly predictive signature of cognition and brain atrophy for progression to Alzheimer's dementia

1. Angela Tam
2. Christian Dansereau
3. Yasser Iturria-Medina
4. Sebastian Urchs
5. Pierre Orban
6. Hanad Sharmarke
7. John Breitner
8. Pierre Bellec
9. Alzheimer's Disease Neuroimaging Initiative

Reviewed by GigaScience

A databank for intracellular electrophysiological mapping of the adult somatosensory cortex

1. Angelica da Silva Lantyer
2. Niccolò Calcini
3. Ate Bijlsma
4. Koen Kole
5. Melanie Emmelkamp
6. Manon Peeters
7. Wim J J Scheenen
8. Fleur Zeldenrust
9. Tansu Celikel

Reviewed by GigaScience

Advanced lesion symptom mapping analyses and implementation as BCBtoolkit

1. Chris Foulon
2. Leonardo Cerliani
3. Serge Kinkingnéhun
4. Richard Levy
5. Charlotte Rosso
6. Marika Urbanski
7. Emmanuelle Volle
8. Michel Thiebaut de Schotten

Reviewed by GigaScience