Neuroscience

The Spatial and Cell-Type Distribution of SARS-CoV-2 Receptor ACE2 in the Human and Mouse Brains

1. Rongrong Chen
2. Keer Wang
3. Jie Yu
4. Derek Howard
5. Leon French
6. Zhong Chen
7. Chengping Wen
8. Zhenghao Xu

Reviewed by ScreenIT

SARS-CoV-2 Receptors and Entry Genes Are Expressed in the Human Olfactory Neuroepithelium and Brain

1. Leon Fodoulian
2. Joël Tuberosa
3. Daniel Rossier
4. Madlaina Boillat
5. Chenda Kan
6. Véronique Pauli
7. Kristof Egervari
8. Johannes A. Lobrinus
9. Basile N. Landis
10. Alan Carleton
11. Ivan Rodriguez

Reviewed by ScreenIT

A monocarboxylate transporter rescues frontotemporal dementia and Alzheimer’s disease models

1. Dongwei Xu
2. Alec Vincent
3. Andrés González-Gutiérrez
4. Benjamin Aleyakpo
5. Sharifah Anoar
6. Ashling Giblin
7. Magda L. Atilano
8. Mirjam Adams
9. Dunxin Shen
10. Annora Thoeng
11. Elli Tsintzas
12. Marie Maeland
13. Adrian M. Isaacs
14. Jimena Sierralta
15. Teresa Niccoli

Reviewed by Review Commons

Two extreme Loss-of-Function GRIN2B -mutations are detrimental to tri-heteromeric NMDAR-function, but rescued by pregnanolone-sulfate

1. Shai Kellner
2. Shai Berlin

Reviewed by Review Commons

Developmental Alterations in Brain Network Asymmetry in 3- to 9-Month Infants with Congenital Sensorineural Hearing Loss

1. Guangfang Liu
2. Xin Zhou
3. Zhenyan Hu
4. Yidi Liu
5. Endi Huo
6. Heather Bortfeld
7. Qi Dong
8. Haihong Liu
9. Haijing Niu

• Curated by eLife

  eLife assessment

  This study presents findings on changes in brain network asymmetry in infants with congenital hearing loss. The findings are valuable but the evidence supporting the claims is incomplete and needs more appropriate and strict statistical analyses. The findings will be of interest to psychologists, neuroscientists, and clinicians.

Reviewed by eLife

Prior information enhances tactile representation in primary somatosensory cortex

1. Pegah Kassraian
2. Finn Rabe
3. Nadja Enz
4. Marloes Maathuis
5. Nicole Wenderoth

• Curated by eLife

  eLife assessment

  This study presents a valuable set of findings on how prior expectations modulate tactile sensory processing. The neuroimaging evidence supporting the main conclusions is solid, although the nature of the experimental task somewhat limits the interpretation of the findings. This work will be of interest to neuroscientists working on sensory processing and perception.

Reviewed by eLife

Distinct hippocampal and cortical contributions in the representation of hierarchies

1. Robert Scholz
2. Arno Villringer
3. Mauricio J.D. Martins

• Curated by eLife

  eLife assessment

  This valuable study investigates how hierarchies are processed in the brain, using a paradigm that intends to bridge disparate domains (e.g., language/music and memory). The main findings are that hippocampus and medial prefrontal cortex are sensitive to hierarchy position, while the response in inferior frontal gyrus seems to vary with amount of experience with the hierarchy. Evidence supporting these claims is solid, and would be strengthened by additional methodological clarifications (e.g., as to why the particular analyses are most appropriate for the research question) and further discussion of limitations related to the study design (e.g., the possibility that the task does not require hierarchical representations).

Reviewed by eLife

FriendlyClearMap: An optimized toolkit for mouse brain mapping and analysis

1. Moritz Negwer
2. Bram Bosch
3. Maren Bormann
4. Rick Hesen
5. Lukas Lütje
6. Lynn Aarts
7. Carleen Rossing
8. Nael Nadif Kasri
9. Dirk Schubert

Reviewed by GigaScience

Diversity and evolution of cerebellar folding in mammals

1. Katja Heuer
2. Nicolas Traut
3. Alexandra Allison de Sousa
4. Sofie Louise Valk
5. Julien Clavel
6. Roberto Toro

• Curated by eLife

  eLife assessment

  This important study gives novel insight into the folding diversity of the cerebellum compared to the cerebrum among 56 mammalian species. Based on impressive data, the analyses performed for anatomical descriptions and phylogenetic comparisons are solid, although some issues need to be addressed regarding the choice of statistical models, and the sample size versus the number of explanatory variables. This study will be of interest to neuroscientists, evolutionary and developmental biologists, and physicists interested in biomechanics, as these observations provide a basis for models of brain folding mechanisms.

Reviewed by eLife

Balancing true and false detection of intermittent sensory targets by adjusting the inputs to the evidence accumulation process

1. Anna C Geuzebroek
2. Hannah Craddock
3. Redmond G O'Connell
4. Simon P Kelly

• Curated by eLife

  eLife assessment

  This research provides convincing evidence that standard behavioral modeling and EEG-derived signatures of the decision process may not agree on mechanisms underlying changes in decision strategy. The authors make a strong case for the importance of informing behavioral modeling with putative neural signatures of the corresponding decision processes. The assumptions of this neurally-informed modeling approach should be further explored and clarified to highlight not only its benefits but also potential caveats.

Reviewed by eLife