Neuroscience

Quantifying decision-making in dynamic, continuously evolving environments

1. Maria Ruesseler
2. Lilian Aline Weber
3. Tom Rhys Marshall
4. Jill O'Reilly
5. Laurence Tudor Hunt

• Curated by eLife

  eLife assessment

  The authors use a clever experimental design and approach to tackle an important set of questions in the field of decision-making. From this work, the authors have a number of intriguing results. However, questions remain regarding the extent to which a number of alternative models and interpretations, not considered in the paper, could account for the observed effects.

Reviewed by eLife

Astrocyte and L-lactate in the anterior cingulate cortex modulate schema memory and neuronal mitochondrial biogenesis

1. Mastura Akter
2. Mahadi Hasan
3. Aruna Surendran Ramkrishnan
4. Zafar Iqbal
5. Xianlin Zheng
6. Zhongqi Fu
7. Zhuogui Lei
8. Anwarul Karim
9. Ying Li

• Curated by eLife

  eLife assessment

  This is an important study that investigates the role of astrocytic Gi signaling in the anterior cingulate cortex in the modulation of extracellular L-lactate level and consequently impairment in flavor-place associates (PA) learning. However, whereas some of the behavioral observations and signaling mechanism data are compelling, the conclusions about effects on memory and the role of L-lactate are based on inadequate methods. With the addition of a few key experiments, this work will be of interest to neuroscientists studying learning and memory and the contribution of astrocytes to these processes.

Reviewed by eLife

Astrocytes gate long-term potentiation in hippocampal interneurons

1. Weida Shen
2. Yejiao Tang
3. Jing Yang
4. Linjing Zhu
5. Wen Zhou
6. Liyang Xiang
7. Feng Zhu
8. Jingyin Dong
9. Yicheng Xie
10. Ling-Hui Zeng

• Curated by eLife

  eLife assessment

  The study presents valuable insights into the regulation of astrocytes in the long-term potentiation of excitatory synapses onto inhibitory interneurons. However, reviewers identified concerns regarding originality and proper acknowledgment of replicated work, representation of interneuron diversity, and the robustness of certain conclusions. The strength of evidence provided is deemed incomplete, necessitating significant revisions for clarity, and accuracy, and to address highlighted concerns.

Reviewed by eLife

The Lack of Synapsin Alters Presynaptic Plasticity at Hippocampal Mossy Fibers in Male Mice

1. Felicitas Bruentgens
2. Laura Moreno Velasquez
3. Alexander Stumpf
4. Daniel Parthier
5. Jörg Breustedt
6. Fabio Benfenati
7. Dragomir Milovanovic
8. Dietmar Schmitz
9. Marta Orlando

Reviewed by PREreview

Approach-avoidance reinforcement learning as a translational and computational model of anxiety-related avoidance

1. Yumeya Yamamori
2. Oliver J Robinson
3. Jonathan P Roiser

• Curated by eLife

  eLife assessment

  This is a valuable paper demonstrating the validity of a novel task that could advance the field of reinforcement learning to better incorporate threat processing in approach-avoidance-conflict. A compelling methodology includes the use of online samples and computational modelling, psychometrics, discovery/replication and pre-registration. This work provides a foundation for future work, which is required to establish this task as relevant to psychopathology and treatment.

Reviewed by eLife

Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function

1. Surjeet Mastwal
2. Xinjian Li
3. Rianne Stowell
4. Matthew Manion
5. Wenyu Zhang
6. Nam-Shik Kim
7. Ki-Jun Yoon
8. Hongjun Song
9. Guo-Li Ming
10. Kuan Hong Wang

• Curated by eLife

  eLife assessment

  This is an important study that addresses the interesting question of whether stimulation of DA input to prefrontal cortex during adolescence can be used to rescue genetic defects on DA regulation of PFC function. The conclusions are convincingly supported by the data together with discussion of some limitations of the approach. This story will of interest to a broad group of neuroscientists interested in regulation of prefrontal cortical function in behavior.

Reviewed by eLife

Laws for Glia Organization Conserved Across Mammals

1. Antonio Pinto-Duarte
2. Katharine Bogue
3. Terrence J. Sejnowski
4. Shyam Srinivasan

Reviewed by Arcadia Science

Genomic stability of self-inactivating rabies

1. Ernesto Ciabatti
2. Ana González-Rueda
3. Daniel de Malmazet
4. Hassal Lee
5. Fabio Morgese
6. Marco Tripodi

• Curated by eLife

  eLife assessment

  The authors previously developed a tool with the goal of non-toxic trans-synaptic tracing using a modified rabies virus, an important goal for the neuroscience field. The tool has the propensity to accumulate mutations over time that promote toxicity, and the manuscript here describes techniques to avoid these mutations. It remains important to show that the non-mutated virus can serve as an effective trans-synaptic tracing tool.

Reviewed by eLife

Optogenetic activation of visual thalamus generates artificial visual percepts

1. Jing Wang
2. Hamid Azimi
3. Yilei Zhao
4. Melanie Kaeser
5. Pilar Vaca Sánchez
6. Abraham Vazquez-Guardado
7. John A Rogers
8. Michael Harvey
9. Gregor Rainer

• Curated by eLife

  eLife assessment

  This important study shows that tree shrews can detect optogenetic stimulation of the lateral geniculate nucleus (LGN) after training detection of visual stimuli. The solid evidence links optogenetic stimulation of the LGN to behavioural detection and neurophysiological responses. This paper is potentially of interest to neuroscientists and clinicians working on the visual system and visual prostheses.

Reviewed by eLife

Olfaction regulates peripheral mitophagy and mitochondrial function

1. Julian G. Dishart
2. Corinne L. Pender
3. Koning Shen
4. Hanlin Zhang
5. Megan Ly
6. Madison B. Webb
7. Andrew Dillin

Reviewed by PREreview