Neuroscience

Synergistic MAPT mutations as a platform to uncover modifiers of tau pathogenesis

1. Miles R Bryan
2. Michael F Almeida
3. Kyle Pellegrino
4. Carli K Opland
5. J Ethan Paulakonis
6. Jake McGillion-Moore
7. Hanna Trzeciakiewicz
8. Diamond King
9. Xu Tian
10. Jui-Heng Tseng
11. Jonathan C Schisler
12. Nicholas G Brown
13. Ben A Bahr
14. Todd J Cohen

• Curated by eLife

  eLife Assessment

  This study presents compelling new data that combine two FTD-tau mutations, P301L/S320F (PL-SF), that reliably induce spontaneous full-length tau aggregation across multiple cellular systems. The findings are important for the field of neurodegenerative disease. The strength of evidence is solid; however, several conclusions would benefit from more validation.

Reviewed by eLife

Decoding Spine Nanostructure in Mental Disorders Reveals a Schizophrenia-Linked Role for Ecrg4

1. Yutaro Kashiwagi
2. Qingrui Liu
3. Yasuhiro Go
4. Ryo Saito
5. Atsu Aiba
6. Takanobu Nakazawa
7. Shigeo Okabe

• Curated by eLife

  eLife Assessment

  By investigating spine nanostructure and dynamics across multiple genetic mouse models for neurodevelopmental disorders, this important study has the potential to uncover convergent or divergent synaptic phenotypes that may be specifically associated with autism versus schizophrenia risk. While the imaging and breadth are impressive, there are potential methodological concerns, especially around statistical analyses, which render the evidence incomplete and should be addressed. The purely in vitro nature of the study also slightly limits the generalisability of the findings.

Reviewed by eLife

A neuropeptide-specific signaling pathway for state-dependent regulation of the mesolimbic dopamine system

1. Mollie X. Bernstein
2. Omar Koita
3. Marta Trzeciak
4. Andrew Fan
5. Daniel T. McAuley
6. Seung-Woo Jin
7. Larry S. Zweifel

Reviewed by PREreview

ATF4 activates a transcriptional program that chronically suppresses mTOR activity promoting neurodegeneration in Parkinson’s disease models

1. Matthew D. Demmings
2. Erica A. Kane
3. Elizabeth C. Tennyson
4. Kate Hurley
5. Joy Zhao
6. Nicholas A. Cruickshanks
7. Victoria Ciz
8. Jordan M. Krupa
9. Stephen H. Pasternak
10. Sean P. Cregan

Reviewed by PREreview

Grid cells encode reward distance during path integration in cue-rich environments

1. Satoshi Kuroki
2. Sébastien Royer

Reviewed by PREreview

Reduced melanocortin tone mediates increased feeding during pregnancy in mice

1. Ingrid Camila Possa-Paranhos
2. Kerem Catalbas
3. Samuel Congdon
4. Tanya Pattnaik
5. Christina Nelson
6. Dajin Cho
7. Patrick Sweeney

Reviewed by PREreview

Nociceptors use multiple neurotransmitters to drive pain

1. Donald Iain MacDonald
2. Rakshita Balaji
3. Alexander T. Chesler

Reviewed by PREreview

Dietary restriction promotes neuronal resilience via ADIOL

1. Ana Guijarro-Hernández
2. Shinja Yoo
3. George A. Lemieux
4. Sena Komatsu
5. Abdullah Q. Latiff
6. Rishika R. Patil
7. Kaveh Ashrafi

Reviewed by PREreview

The encoding of interoceptive-based predictions by the paraventricular nucleus of the thalamus D2R+ neurons

1. Briana Machen
2. Sierra N. Miller
3. Al Xin
4. Carine Lampert
5. Lauren Assaf
6. Julia Tucker
7. Sarah Herrell
8. Francisco Pereira
9. Gabriel Loewinger
10. Sofia Beas

Reviewed by PREreview

The representation of facial emotion expands from sensory to prefrontal cortex with development

1. Xiaoxu Fan
2. Abhishek Tripathi
3. Kelly Bijanki

• Curated by eLife

  **eLife Assessment
  **
  This study examines an important question regarding the developmental trajectory of neural mechanisms supporting facial expression processing. Leveraging a rare intracranial EEG (iEEG) dataset including both children and adults, the authors reported that facial expression recognition mainly engaged the posterior superior temporal cortex (pSTC) among children, while both pSTC and the prefrontal cortex were engaged among adults. In terms of strength of evidence, the solid methods, data and analyses broadly support the claims with minor weaknesses.

Reviewed by eLife