1. Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

    This article has 8 authors:
    1. Abdulkadir Ozkan
    2. Hari K Padmanabhan
    3. Seth L Shipman
    4. Eiman Azim
    5. Priyanka Kumar
    6. Cameron Sadegh
    7. A Nazli Basak
    8. Jeffrey D Macklis
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents fundamental new findings introducing a new approach for the reprogramming of brain glial cells to corticospinal neurons. The data is highly compelling, with multiple lines of evidence demonstrating the success of this new assay. These exciting findings set the stage for future studies of the potential of these reprogrammed cells to form functional connections in vivo and their utility in clinical conditions where corticospinal neurons are compromised.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  2. Orexin population activity precisely reflects net body movement across behavioral and metabolic states

    This article has 8 authors:
    1. Alexander L Tesmer
    2. Paulius Viskaitis
    3. Dane Donegan
    4. Eva F Bracey
    5. Nikola Grujic
    6. Tommaso Patriarchi
    7. Daria Peleg-Raibstein
    8. Denis Burdakov
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study shows that the activity of hypothalamic hypocretin/orexin neurons (HONs) correlates with body movement over multiple behaviors. Compelling evidence, supported by sophisticated, cutting-edge tools and data analyses, highlights a link that appears to be unique to HONs. This work should be of interest to scientists studying peptidergic neurons, movement, energy regulation, and brain-body coordination.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  3. Adaptation invariant concentration discrimination in an insect olfactory system

    This article has 5 authors:
    1. Doris Ling
    2. Lijun Zhang
    3. Debajit Saha
    4. Alex Bo-Yuan Chen
    5. Baranidharan Raman
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study addresses an important question in sensory neuroscience: how the olfactory system distinguishes decreases in stimulus intensity from decreases in neural responses due to adaptation. Based on a combination of electrophysiological and behavioral analyses, solid evidence establishes that neural coding changes differently between intensity reductions and adaptation, with intensity changes altering which neurons are activated while adaptation preserves the active ensemble but reduces response magnitude. Intriguingly, behavioral responses tend to increase as the neural responses decrease, suggesting that core features of the odor response persist through adaptation. While the experimental results are convincing overall, the conclusions will be strengthened by future work recording behavior and neural dynamics in the same animals.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  4. Astrocytic connexin43 phosphorylation contributes to seizure susceptibility after mild traumatic brain injury

    This article has 11 authors:
    1. Carmen Muñoz-Ballester
    2. Owen Leitzel
    3. Samantha Golf
    4. Chelsea M Phillips
    5. Michael J Zeitz
    6. Rahul Pandit
    7. Elizabeth Wash
    8. Jenna V. Donohue
    9. James W. Smyth
    10. Samy Lamouille
    11. Stefanie Robel

    Reviewed by Review Commons

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  5. Phase-specific premotor inhibition modulates leech rhythmic motor output

    This article has 4 authors:
    1. Martina Radice
    2. Agustín Sanchez Merlinsky
    3. Federico Yulita
    4. Lidia Szczupak
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The medicinal leech preparation is an amenable system in which to understand the neural basis of locomotion. Here a previously identified non-spiking neuron was studied in leech and found to alter the mean firing frequency of a crawl-related motoneuron, which fires during the contraction phase of crawling. The findings are valuable and the experiments were diligently done and generally solid; The results lay a foundation for additional studies in this system.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  6. Social Experience Shapes Fighting Strategies for Reproductive Success

    This article has 6 authors:
    1. Can Gao
    2. Mingze Ma
    3. Jie Chen
    4. Xiaoxiao Ji
    5. Qionglin Peng
    6. Yufeng Pan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The paper presents a new behavioral assay for Drosophila aggression and demonstrates that social experience influences fighting strategies, with group-housed males favoring high-intensity but low-frequency tussling over aggressive lunging observed in isolated males. This paper is important for researchers studying the impact of social isolation on aggression, while the description of tussling behavior and the interpretation of the link between tussling and mating success are incomplete.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  7. Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline

    This article has 8 authors:
    1. Rui Feng
    2. Sarah F Rosen
    3. Irshad Ansari
    4. Sebastian John
    5. Michael B Thomsen
    6. Oshri Avraham
    7. Cedric G Geoffroy
    8. Valeria Cavalli
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study examines the role of endothelin signaling in nerve regeneration, providing convincing evidence that it functions as a default brake on axon regrowth. Inhibiting endothelin signaling with Bosentan promotes regeneration and counteracts the decline in regenerative potential caused by aging. Since Bosentan is an FDA-approved drug, these findings could have therapeutic value in clinical settings where peripheral nerve regeneration is not adequate or seriously impaired, as is often the case in older individuals.

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    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  8. An applicable and efficient retrograde monosynaptic circuit mapping tool for larval zebrafish

    This article has 11 authors:
    1. Tian-Lun Chen
    2. Qiu-Sui Deng
    3. Kun-Zhang Lin
    4. Xiu-Dan Zheng
    5. Xin Wang
    6. Yong-Wei Zhong
    7. Xin-Yu Ning
    8. Ying Li
    9. Fu-Qiang Xu
    10. Jiu-Lin Du
    11. Xu-Fei Du
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study offers substantial technical advancements for neural circuit tracing in larval zebrafish, a model for systems and developmental neurobiology. The enhanced rabies virus-based retrograde transneuronal tracing improves efficiency and provides a method for combined structural and functional brain mapping. The supporting evidence is solid, and there is strong confidence in the technique's utility for neurobiologists working with zebrafish.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  9. Working memory shapes neural geometry in human EEG over learning

    This article has 7 authors:
    1. Michał J Wójcik
    2. Amy Li
    3. Dante Wasmuht
    4. Jake P Stroud
    5. Mark G Stokes
    6. Nicholas E Myers
    7. Laurence T Hunt
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The findings are valuable, given that they highlight the flexible and future-oriented nature of working memory. However, the evidence for the claims about context/color generalization, behavioural relevance of context decoding, dimensionality reduction, neural geometry, the XOR representation, and the specific contribution of working memory is incomplete. The work could be reframed in terms of prospective remapping.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  10. The influence of nucleus accumbens shell D1 and D2 neurons on outcome-specific Pavlovian instrumental transfer

    This article has 6 authors:
    1. Octavia Soegyono
    2. Elise Pepin
    3. Beatrice K Leung
    4. Billy C Chieng
    5. Bernard W Balleine
    6. Vincent Laurent
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides novel and convincing evidence that both dopamine D1 and D2 expressing neurons in the nucleus accumbens shell are crucial for the expression of cue-guided action selection, a fundamental component of decision-making. The research is systematic and rigorous in using optogenetic inhibition of either D1- or D2-expressing medium spiny neurons in the NAc shell to reveal attenuation of sensory-specific Pavlovian-Instrumental transfer, while largely sparing value-based decision on an instrumental task. Findings in this report build on prior research and resolve some conflicts in the literature regarding decision making.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
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