Neuroscience

eLife Assessment

This important study examines the stability and compensatory plasticity in the retinotopic mapping in patients with congenital achromatopsia. It provides convincing evidence for a stable mapping of the visual field in V1, alongside changes of the readout from V1 into V3, which shows revised receptive field location and size. This paper would be of interest to scientists studying the visual system, brain plasticity, and development.

eLife Assessment

This study addresses an important question about how large-scale brain networks interact, and specifically how the default mode network exchanges information with the sensory cortex. The analyses are sophisticated, but at present provide incomplete evidence for the claims made in the paper.

eLife Assessment

The valuable study aims to differentiate between foveal and peripheral attentional mechanisms in visual and frontal brain regions in monkeys engaged in a free-gaze visual search task. The authors interpret differences in responses between target and nontarget conditions as feature-based attention; however, this may not be the correct interpretation. The authors do not provide enough information on how they distinguish foveal and peripheral RFs. Consequently, the study provides only incomplete evidence that does not support the authors' conclusions, and the significance of the findings is not strong.

eLife Assessment

This is an important study that takes a key step towards understanding developmental disorders linked to mutations in the O-GlcNAc transferase enzyme by generating a mouse model harboring the C921Y mutation. While the mechanisms remain open, the study thoroughly examines behavioral and anatomical differences in these mice and provides convincing evidence for behavioral hyperactivity and learning/memory deficits, as well as phenotypic differences in skull and brain formation. This study will be of interest to those studying neurodevelopmental disorders and associated mechanisms.

eLife Assessment

This fundamental study substantially advances our understanding of sibling chimerism in marmosets by demonstrating that chimerism is limited to hematopoietic cells. The evidence supporting these findings is compelling, demonstrated through comprehensive analyses, including single-cell RNA-seq data from multiple individuals and tissues. A few minor concerns were successfully addressed in a revision. The work will be of broad interest to many fields of biology.

eLife Assessment

This important work examines the effects of gaze on valuation signals in the human brain as participants choose between bundles of sequentially presented items food items. The paper provides convincing analyses of how gaze affects participants choice behaviour and how this varies across time. The work will be of interest to neuroscientists working on attention and decision-making.

eLife Assessment

This manuscript provides a valuable contribution by identifying a stress-responsive circuit and its regulation of anxiety-related behaviors. The evidence is convincing that the supramammillary nucleus contains stress-responsive neurons that increase anxiety-like behaviors when activated, and that ventral subiculum projections to the supramammillary are also activated by stress and their inhibition alleviates some effects of stress. Evidence that this pathway encodes and is functionally specific to anxiety is, at present, not sufficiently support and will require future studies. This work offers new insights into how distinct circuits are activated by stress and can regulate emotional behaviors and will be of interest to those interested in brain systems of aversive emotional and behavioral states.