1. Patchy Striatonigral Neurons Modulate Locomotor Vigor in Response to Environmental Valence

    This article has 9 authors:
    1. Sarah Hawes
    2. Bo Liang
    3. Braden Oldham
    4. Breanna T Sullivan
    5. Lupeng Wang
    6. Bin Song
    7. Lisa Chang
    8. Da-Ting Lin
    9. Huaibin Cai
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The manuscript by Hawes et al. provides important findings on how striatal projection neurons regulate spontaneous locomotion speed in the context of implicit motivation and distinct contextual valence. Overall, the evidence for the findings is solid, although evidence for the claim that striatonigral projections from the matrix and patches have functionally opposing roles is incomplete. This work will be of broad interest to neuroscientists in the basal ganglia, movement control, and cognition fields.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. AgRP1 modulates breeding season-dependent feeding behavior in female medaka

    This article has 9 authors:
    1. Yurika Tagui
    2. Shingo Takeda
    3. Hiroyo Waida
    4. Shoichi Kitahara
    5. Tomoki Kimura
    6. Shinji Kanda
    7. Yoshitaka Oka
    8. Yu Hayashi
    9. Chie Umatani
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript provides fundamental new insight into the mechanisms linking photoperiod, reproduction function, and feeding activity, using medaka, a genetic model that itself exhibits photoperiodic responses. As well as identifying key neuropeptide genes that are regulated by photoperiod and involved in regulating feeding activity, the authors establish a knockout line for agrp1 using CRISPR Cas9 - based approach, profiting from the extensive use and development on this methodology in medaka. The combination of the RNAseq and quantitative in situ hybridization analysis with the knockout results as well as the study of ovariectomized fish provides compelling evidence implicating agrp1 in feeding regulation in response to photoperiod and reproductive status.

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    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  3. Rapid and Inducible Mislocalization of Endogenous TDP43 in a Novel Human Model of Amyotrophic Lateral Sclerosis

    This article has 6 authors:
    1. Johanna Ganssauge
    2. Sophie Hawkins
    3. Seema C Namboori
    4. Szi Kay Leung
    5. Jonathan Mill
    6. Akshay Bhinge
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      TDP-43 mislocalization is a key feature of some neurodegenerative diseases, but cellular models are lacking. The authors endogenously-tagged TDP-43 with a C-terminal GFP tag in human iPSCs, followed by expression of an intrabody-NES that targeted GFP to the cytosol. They convincingly report physical mislocalization and functional depletion of TDP-43, as measured by microscopy and RNAseq. This method will be valuable to investigators studying the biological consequences of TDP-43 mislocalization and the methodology is in line with the current state-of-the-art.

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    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  4. Bridging verbal coordination and neural dynamics

    This article has 6 authors:
    1. Isaïh Schwab-Mohamed
    2. Manuel R. Mercier
    3. Agnès Trébuchon
    4. Benjamin Morillon
    5. Leonardo Lancia
    6. Daniele Schön
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This paper reports on an important study that aims to move beyond current experimental approaches in speech production by (1) investigating speech in the context of a fully interactive task and (2) employing advanced methodology to record intracranial brain activity. Together these allow for examination of the unfolding temporal dynamics of brain-behaviour relationships during interactive speech. This approach and the analyses presented in support of the authors' claims pose convincing evidence.

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    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  5. Prediction tendency, eye movements, and attention in a unified framework of neural speech tracking

    This article has 5 authors:
    1. Juliane Schubert
    2. Quirin Gehmacher
    3. Fabian Schmidt
    4. Thomas Hartmann
    5. Nathan Weisz
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      These are valuable findings for those interested in how neural signals reflect auditory speech streams, and in understanding the roles of prediction, attention, and eye movements in this tracking. However, the evidence as it stands is incomplete. Further analyses are needed to clarify how the observed results relate to the relevant theoretical claims.

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    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  6. Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues

    This article has 34 authors:
    1. Adam Glaser
    2. Jayaram Chandrashekar
    3. Sonya Vasquez
    4. Cameron Arshadi
    5. Rajvi Javeri
    6. Naveen Ouellette
    7. Xiaoyun Jiang
    8. Judith Baka
    9. Gabor Kovacs
    10. Micah Woodard
    11. Shamishtaa Seshamani
    12. Kevin Cao
    13. Nathan Clack
    14. Andrew Recknagel
    15. Anna Grim
    16. Pooja Balaram
    17. Emily Turschak
    18. Marcus Hooper
    19. Alan Liddell
    20. John Rohde
    21. Ayana Hellevik
    22. Kevin Takasaki
    23. Lindsey Erion Barner
    24. Molly Logsdon
    25. Chris Chronopoulos
    26. Saskia EJ de Vries
    27. Jonathan T Ting
    28. Steven Perlmutter
    29. Brian E Kalmbach
    30. Nikolai Dembrow
    31. Bosiljka Tasic
    32. R Clay Reid
    33. David Feng
    34. Karel Svoboda
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The ExA-SPIM methodology developed here and characterized and supported by convincing evidence is an important development for the field of light sheet microscopy as the new technology provides an impressive field of view making it possible to image the entire expanded mouse brain at cellular and subcellular resolution.

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    This article has 11 evaluationsAppears in 2 listsLatest version Latest activity
  7. A Stimulus-Computable Model for Audiovisual Perception and Spatial Orienting in Mammals

    This article has 1 author:
    1. Cesare V. Parise
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is an important study introducing a stimulus-computable model of multisensory perception that extends an existing framework to accept raw, stimulus-level inputs (i.e., image- and soundscape-computable). The author demonstrates how low-level correlation detection can drive both illusions and cue integration, and the model bridges diverse stimuli, behaviors, and species. The model and evidence provided are deemed generally convincing and of broad applicability, potentially impacting areas across neuroscience, psychology, and computational cognitive science. There are, however, certain aspects of the work considered incomplete, particularly as they relate to explaining details pertinent to model fitting.

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    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. Cellular and synaptic organization of the Octopus vertical lobe

    This article has 5 authors:
    1. Flavie Bidel
    2. Yaron Meirovitch
    3. Fuming Yang
    4. Jeff William Lichtman
    5. Binyamin Hochner
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study of the inhibitory complex amacrines (CAM) in the vertical lobe of Octopus vulgaris delivers a solid standard for the structural characterization of an anatomical region likely to be key for memory processing in this unconventional but complex organism, as well as a helpful classification of CAM subtypes. This work will be of broad relevance to the fields of memory and evolutionary neuroscience.

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  9. Fingertip viscoelasticity enables human tactile neurons to encode loading history alongside current force

    This article has 3 authors:
    1. Hannes P Saal
    2. Ingvars Birznieks
    3. Roland S Johansson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The fundamental findings reported here provide insight into how the viscoelasticity of the fingertip skin influences the activity of mechanoreceptive afferents and thus the neural coding of force in humans. The basic principle studied was whether and to what extent the previous applied force directions impact the firing of FA-1, SA-1 and SA-2 neurons during the current applied force directions. The data and analyses are compelling and will be helpful for modeling the neural representations of force in the context of object grasping and manipulation.

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    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  10. Integration of head and body orientations in the macaque superior temporal sulcus is stronger for upright bodies

    This article has 2 authors:
    1. Yordanka Zafirova
    2. Rufin Vogels
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study examines the neuronal mechanisms underlying visual perception of integrated face and body cues. The innovative paradigm, which employs monkey avatars in combination with electrophysiological recordings from fMRI-defined brain areas, provides compelling evidence on face and body integration. These results should be of wide interest to system and cognitive neuroscientists, psychologists, and behavioural biologists working on visual and social cognition.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
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