Neuroscience

Challenges and Efficacy of Astrocyte-to-Neuron Reprogramming in Spinal Cord Injury: In Vitro Insights and In Vivo Outcomes

1. ALESSIA NICEFORO
2. Lyandysha V Zholudeva
3. Silvia Fernandes
4. Yashvi Shah
5. Michael A Lane
6. Liang Qiang

Reviewed by PREreview

Mid1 deletion leads to cognitive dysfunction in Opitz syndrome by regulates neural rhythms through the inhibition of p-Creb by PP2Ac

1. Ziye Yang
2. Pengxiang Li
3. Yue Chen
4. Xiaoyu Guo
5. Ping Liu
6. Guangjian Ni
7. Shuang Liu
8. Liqun Chen
9. Dong Ming

• Curated by eLife

  eLife Assessment

  This study provides important insights into the role of the Mid1 gene in hippocampal development and its implications in Opitz G/BBB syndrome, with much evidence supporting its impact on synaptic plasticity, neural rhythms, and cognitive functions. The methods, data, and analyses are solid, supporting the claims, presenting several minor weaknesses, and establishing Mid1 as a potential therapeutic target for neurological deficits associated with OS. The conclusions are largely supported by the results, but additional data are needed.

Reviewed by eLife

Multiple and subject-specific roles of uncertainty in reward-guided decision-making

1. Alexander Paunov
2. Maëva L’Hôtellier
3. Dalin Guo
4. Zoe He
5. Angela Yu
6. Florent Meyniel

• Curated by eLife

  eLife Assessment

  The findings of this study are valuable, as they address a critical methodological gap in decision-making research by demonstrating how heuristic strategies can confound interpretations of uncertainty-driven behaviour and provide a clearer framework for distinguishing between uncertainty-seeking and heuristic-driven exploration. While the evidence is solid, with strong methodological rigour in task design and computational modelling, some claims, such as the stability of uncertainty parameters and correlations with psychopathology measures, require refinement. Overall, the data broadly support the study's claims, but interpretational ambiguities limit the impact of certain findings.

Reviewed by eLife