Neuroscience

In vivo and in silico alpha-synuclein propagation dynamics: The role of genotype, epicentre, and connectivity

1. Stephanie Tullo
2. Janice SH Park
3. Shady Rahayel
4. Daniel Gallino
5. Megan Park
6. Kristie Mar
7. Ying-Qiu Zheng
8. Esther del Cid-Pellitero
9. Edward A. Fon
10. Wen Luo
11. Irina Shlaifer
12. Thomas M. Durcan
13. Bratislav Misic
14. Alain Dagher
15. Gabriel A. Devenyi
16. M. Mallar Chakravarty

• Curated by eLife

  eLife Assessment

  This important study provides solid evidence that, in an α-synucleinoathy model, brain atrophy and associated functional decline generalize across host genotype and fibril species, while being strongly shaped by the site of seeding and regional vulnerability. With an unusually large longitudinal in vivo MRI dataset combined with behavioural and computational modelling, the study offers a comprehensive characterization of neurodegeneration across multiple biological and experimental conditions. The openly shared imaging dataset and analysis pipeline are an excellent resource, and the scale, longitudinal design, methodological breadth, and openness of the study make it a substantial contribution to the field. This work will be of interest to scientists in synucleinopathy- and network- neurodegeneration communities.

Reviewed by eLife