1. Perceptual versus attentional impairments of conscious access: Distinct neural mechanisms despite equal task performance

    This article has 4 authors:
    1. Samuel Noorman
    2. Timo Stein
    3. Johannes J. Fahrenfort
    4. Simon van Gaal
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study provides new insights into the mechanisms that underlie perceptual and attentional impairments of conscious access. The paper presents convincing evidence of a dissociation between the early stages of low-level perception, which are impermeable to perceptual or attentional impairments, and subsequent stages of visual integration which are susceptible to perceptual impairment but resilient to attentional manipulations. This study will be of interest to scientists working on visual perception and consciousness.

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    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  2. Multi-dimensional social relationships shape social attention in monkeys

    This article has 5 authors:
    1. Sainan Liu
    2. Jiepin Huang
    3. Suhao Chen
    4. Michael Platt
    5. Yan Yang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study examined how multidimensional social relationships influence social attention in rhesus macaques, linking individual and group-level behaviors to attentional processes. The findings that oxytocin altered social attention and its relationship to both social tendencies and dyadic relationships are important, as recent technological advances allow for the exploration of neuronal activities and mechanisms in free-moving macaques. This work is convincing and will be of interest to those studying the interplay between social dynamics and information processing in primates.

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    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  3. Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability

    This article has 10 authors:
    1. Joshua D Garcia
    2. Chenyu Wang
    3. Emmie Banks
    4. Timothy Fenton
    5. Jean-Marc DeKeyser
    6. Tatiana V Abramova
    7. Alfred L George
    8. Roy Ben-Shalom
    9. David H Hackos
    10. Kevin J Bender
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript presents a clever and powerful approach to examining differential roles of Nav1.2 and Nav1.6 channels in excitability of neocortical pyramidal neurons, by engineering mice in which a sulfonamide inhibitor of both channels has reduced affinity for one or the other channels. Overall, the results in the manuscript are compelling and give important information about differential roles of Nav1.6 and Nav1.2 channels. Activity-dependent inactivation of NaV1.6 was also found to attenuate seizure-like activity in cells, demonstrating the promise of activity-dependent NaV1.6-specific pharmacotherapy for epilepsy.

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  4. Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum

    This article has 8 authors:
    1. Aske L Ejdrup
    2. Jakob K Dreyer
    3. Matthew D Lycas
    4. Søren H Jørgensen
    5. Trevor W Robbins
    6. Jeffrey W Dalley
    7. Freja Herborg
    8. Ulrik Gether
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The conclusions of this work are based on valuable simulations of a detailed model of striatal dopamine dynamics. Establishing that a lower dopamine uptake rate can lead to a 'tonic' level of dopamine in the ventral but not dorsal striatum, and that dopamine concentration changes at short delays can be tracked by D1 but not D2 receptor activation, is of value and will be of interest to dopamine aficionados. However, the simulations are incomplete, providing only partial support for the key claims. Several things can be done to strengthen the conclusions, including, for example, but not exclusively, a demonstration of how the results would change as a function of changes in D2 affinity.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. Human Brain-Wide Activation of Sleep Rhythms

    This article has 5 authors:
    1. Haiteng Wang
    2. Qihong Zou
    3. Jinbo Zhang
    4. Jia-Hong Gao
    5. Yunzhe Liu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The study reports valuable findings from a very rich EEG-fMRI dataset including 107 participants, which was collected during nocturnal naps. The authors link activity in memory-related brain regions (e.g., hippocampus, thalamus, and medial prefrontal cortex), and their functional connectivity, to the occurrence of canonical sleep rhythms, namely spindles and slow oscillations in non-rapid eye movement sleep. This work could contribute to further understanding of sleep neural dynamics, although the evidence for some of the main claims is incomplete at present.

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  6. Neurons in the medial prefrontal cortex that are not modulated by hippocampal sharp-wave ripples are involved in spatial tuning and signaling upcoming choice

    This article has 2 authors:
    1. Hanna den Bakker
    2. Fabian Kloosterman
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This useful study reports analyses of Neuropixel recordings in the medial prefrontal cortex and hippocampus of rats in a spatial navigation trial, focusing on classifying prefrontal neurons based on SWR modulation and anatomical location. However, the evidence for claims of a clear link between SWR modulation and neuronal encoding, and the evidence for anatomical organization, is currently incomplete. Further analyses might strengthen the evidence for some conclusions, and some of the strong claims of the paper should likely be moderated.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Dynamic Gamma Modulation of Hippocampal Place Cells Predominates Development of Theta Sequences

    This article has 10 authors:
    1. Ning Wang
    2. Yimeng Wang
    3. Mingkun Guo
    4. Ling Wang
    5. Xueling Wang
    6. Nan Zhu
    7. Jiajia Yang
    8. Lei Wang
    9. Chenguang Zheng
    10. Dong Ming
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Using electrophysiological recordings in freely moving rats, this valuable study investigates the role of different gamma frequency bands in the development of spatial representations in the hippocampus. Solid evidence supports the idea that gamma-modulated neurons are crucial for generating specific neuronal sequences. These findings will be of interest to neuroscientists studying spatial navigation and neuronal dynamics.

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    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  8. A deep learning framework for automated and generalized synaptic event analysis

    This article has 9 authors:
    1. Philipp S O’Neill
    2. Martín Baccino-Calace
    3. Peter Rupprecht
    4. Sungmoo Lee
    5. Yukun A Hao
    6. Michael Z Lin
    7. Rainer W Friedrich
    8. Martin Müller
    9. Igor Delvendahl
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This paper presents miniML, an AI-based framework for the detection of synaptic events. Benchmark results presented in the paper are compelling, demonstrating the superiority of miniML over current state-of-the-art alternatives. The performance of miniML is demonstrated across various experimental paradigms, showing that miniML has the potential to become a valuable tool for the analysis of synaptic signals.

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    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  9. Sexual Failure Decreases Sweet Taste Perception in Male Drosophila via Dopaminergic Signaling

    This article has 4 authors:
    1. Gaohang Wang
    2. Wei Qi
    3. Rui Huang
    4. Liming Wang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides valuable findings on the effects of mating experience on sweet taste perception. The data as presented provide solid evidence that the dopaminergic signaling-mediated reward system underlies this mating state-dependent behavioral modulation. The work will interest neuroscientists, particularly those working on neuromodulation and the effects of internal states on behavior.

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  10. Afadin-deficient retinas exhibit severe neuronal lamination defects but preserve visual functions

    This article has 12 authors:
    1. Akiko Ueno
    2. Konan Sakuta
    3. Hiroki Ono
    4. Haruki Tokumoto
    5. Mikiya Watanabe
    6. Taketo Nishimoto
    7. Toru Konishi
    8. Shunsuke Mizuno
    9. Jun Miyoshi
    10. Yoshimi Takai
    11. Masao Tachibana
    12. Chieko Koike
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study demonstrated that the conditional knockout of afadin disrupts retinal laminar organization and reduced number of photoreceptors while preserving some of the structure and light responsiveness of retinal ganglion cells. These findings are solid and useful for understanding afadin's role in retinal cell generation, lamination, and functional organization. However, the study provides limited new insights into the relationship between retinal lamination defects and overall retinal function.

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    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
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