Neuroscience

Mapping patterns of thought onto brain activity during movie-watching

1. Raven S Wallace
2. Brontë Mckeown
3. Ian Goodall-Halliwell
4. Louis Chitiz
5. Philippe Forest
6. Theodoros Karapanagiotidis
7. Bridget Mulholland
8. Adam G Turnbull
9. Tamera Vanderwal
10. Samyogita Hardikar
11. Tirso Gonzalez Alam
12. Boris Bernhardt
13. Hao-Ting Wang
14. Will Strawson
15. Michael Milham
16. Ting Xu
17. Daniel Margulies
18. Giulia L Poerio
19. Elizabeth Jefferies
20. Jeremy I Skipper
21. Jeffery Wammes
22. Robert Leech
23. Jonathan Smallwood

• Curated by eLife

  eLife Assessment

  This study presents a valuable methodological advancement in quantifying thoughts over time. A novel multi-dimensional experience-sampling approach is presented, identifying data-driven patterns that the authors use to interrogate fMRI data collected during naturalistic movie-watching. The experimentation is inventive and the analyses carried out and results presented are convincing.

Reviewed by eLife

Endopiriform neurons projecting to ventral CA1 are a critical node for recognition memory

1. Naoki Yamawaki
2. Hande Login
3. Solbjørg Østergaard Feld-Jakobsen
4. Bernadett Mercedesz Molnar
5. Mads Zippor Kirkegaard
6. Maria Moltesen
7. Aleksandra Okrasa
8. Jelena Radulovic
9. Asami Tanimura

• Curated by eLife

  eLife Assessment

  This important study offers insights into the function and connectivity patterns of a relatively unknown afferent input from the endopiriform to the CA1 subfield of the ventral hippocampus, suggesting a neural mechanism that suppresses the processing of familiar stimuli in favor of detecting memory guided novelty. The strength of evidence is solid, with careful anatomical and electrophysiological circuit characterization. The work will be of broad interest to researchers studying the neural circuitry of behavior.

Reviewed by eLife

TYK2 as a novel therapeutic target in Alzheimer’s Disease with TDP-43 inclusions

1. Laura E. König
2. Steve Rodriguez
3. Clemens Hug
4. Shayda Daneshvari
5. Alexander Chung
6. Gary A. Bradshaw
7. Asli Sahin
8. George Zhou
9. Robyn J. Eisert
10. Federica Piccioni
11. Sudeshna Das
12. Marian Kalocsay
13. Artem Sokolov
14. Peter Sorger
15. David E. Root
16. Mark W. Albers

Reviewed by PREreview

Dysfunctional S1P/S1PR1 signaling in the dentate gyrus drives vulnerability of chronic pain-related memory impairment

1. Mengqiao Cui
2. Xiaoyuan Pan
3. Zhijie Fan
4. Shulin Wu
5. Ran Ji
6. Xianlei Wang
7. Xiangxi Kong
8. Zhou Wu
9. Lingzhen Song
10. Weiyi Song
11. Jun-Xia Yang
12. Hongjie Zhang
13. Hongxing Zhang
14. Hai-Lei Ding
15. Jun-Li Cao

• Curated by eLife

  eLife Assessment

  This study investigates the molecular mechanisms underlying chronic pain-related memory impairment by focusing on S1P/S1PR1 signaling in the dentate gyrus (DG) of the hippocampus. Through behavioral tests (Y-maze and Morris water maze) and RNA-seq analysis, the researchers discovered that S1P/S1PR1 signaling is crucial for determining susceptibility to memory impairment, with decreased S1PR1 expression linked to structural plasticity changes and memory deficits. This work has important significance and a convincing level of evidence, thus offering new insights into the mechanisms underlying chronic pain-related memory impairment.

Reviewed by eLife

Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cells

1. Olivia Taylor
2. Nicholas DeGroff
3. Heithem El-Hodiri
4. Chengyu Gao
5. Andy J Fischer

• Curated by eLife

  eLife Assessment

  This valuable study investigates the signaling pathways regulating retina regeneration. Solid evidence shows that the sphingosine-1-phosphate (S1P) signaling pathway is inhibited following retinal injury. Small-molecule activators and inhibitors support a model in which S1P signaling must be inhibited to generate Müller glia progenitor cells-a key step in retinal regeneration. The presented results support the major conclusions. However, the methodology concerning drug treatments is unclear, and the conceptual innovation is, to some extent, incremental.

Reviewed by eLife

Neural circuit mechanisms for steering control in walking Drosophila

1. Aleksandr Rayshubskiy
2. Stephen L Holtz
3. Alexander Bates
4. Quinn X Vanderbeck
5. Laia Serratosa Capdevila
6. Rachel I Wilson

• Curated by eLife

  eLife Assessment

  This important work investigates how orientation signals detected in higher brain areas may be transformed into motor responses in behaving animals. The authors characterize two types of descending neurons (DNs) that connect the brain to motor units and are involved in different aspects of turning control. They further show that orientation signals act by preferentially increasing relative stimulation onto left- or right-turn-inducing DNs. These convincing results, together with the independent work that they have inspired, represent significant progress in our understanding of mechanisms of animal navigation.

Reviewed by eLife

Pharyngeal neuronal mechanisms governing sour taste perception in Drosophila melanogaster

1. Bhanu Shrestha
2. Jiun Sang
3. Suman Rimal
4. Youngseok Lee

• Curated by eLife

  eLife Assessment

  This is a useful contribution to our understanding of taste perception. The idea that specific receptors function in the pharynx to mediate responses to carboxylic acids is interesting, although the expression analysis is incomplete. Reviewers also have a number of other suggestions for improvement, including the request that authors provide more details about the methodology used. In general, the claims are supported by solid evidence and add to a growing body of literature on this topic.

Reviewed by eLife, preLights

Endosomal sorting protein SNX4 limits synaptic vesicle docking and release

1. Josse Poppinga
2. Nolan J Barret
3. L Niels Cornelisse
4. Matthijs Verhage
5. Jan RT van Weering

• Curated by eLife

  eLife Assessment

  This important study presents a series of results aimed at uncovering the involvement of the endosomal sorting protein SNX4 in neurotransmitter release. While the evidence supporting the conclusions is solid, the molecular mechanisms remain unclear. This paper will be of interest to cell biologists and neurobiologists.

Reviewed by eLife

Fractal cycles of sleep: a new aperiodic activity-based definition of sleep cycles

1. Yevgenia Rosenblum
2. Mahdad Jafarzadeh Esfahani
3. Nico Adelhöfer
4. Paul Zerr
5. Melanie Furrer
6. Reto Huber
7. Famke F Roest
8. Axel Steiger
9. Marcel Zeising
10. Csenge G Horváth
11. Bence Schneider
12. Róbert Bódizs
13. Martin Dresler

• Curated by eLife

  eLife Assessment

  This valuable study provides a novel method to detect sleep cycles based on variations in the slope of the power spectrum from electroencephalography signals. The method, dispensing with time-consuming and potentially subjective manual identification of sleep cycles, is supported by solid evidence and analyses. This study will be of interest to researchers and clinicians working on sleep and brain dynamics.

Reviewed by eLife

Temporal dynamics analysis reveals that concurrent working memory load eliminates the Stroop effect through disrupting stimulus-response mapping

1. Yafen Li
2. Yixuan Lin
3. Qing Li
4. Yongqiang Chen
5. Zhifang Li
6. Antao Chen

• Curated by eLife

  eLife Assessment

  This important study investigates how working memory load influences the Stroop effect from a temporal dynamics perspective. Convincing evidence is provided that the working memory load influences the Stroop effect in the late-stage stimulus-response mapping instead of the early sensory stage. This study will be of interest to both neuroscientists and psychologists who work on cognitive control.

Reviewed by eLife