Neuroscience

Barcode activity in a recurrent network model of the hippocampus enables efficient memory binding

1. Ching Fang
2. Jack Lindsey
3. Larry F Abbott
4. Dmitriy Aronov
5. Selmaan Chettih

• Curated by eLife

  eLife Assessment

  This fundamental work substantially advances our understanding of episodic memory by proposing a biologically plausible mechanism through which hippocampal barcode activity enables efficient memory binding and flexible recall. The evidence supporting the conclusions is convincing, with rigorously validated computational models and alignment with experimental findings. The work will be of broad interest to neuroscientists and computational modelers studying memory and hippocampal function.

Reviewed by eLife

WAChRs are excitatory opsins sensitive to indoor lighting

1. Amanda J. Tose
2. Alberto A. Nava
3. Sara N. McGrath
4. Alan R. Mardinly
5. Alexander Naka

Reviewed by PREreview, Arcadia Science

Semaglutide drives weight loss through cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons

1. Claire Gao
2. Isabelle C. Geneve
3. Chia Li
4. Kaitlyn McElhern
5. Marc L. Reitman
6. Andrew Lutas
7. Michael J. Krashes

Reviewed by PREreview

Central Amygdala Neuronal Ensembles Coordinate Visceral Pain and Its Affective Behaviors

1. Vijay K Samineni
2. Julian N Sackey
3. Jun-Nan Li
4. Lite Yang
5. Alexander Chamessian
6. Sienna B Sewell
7. Hannah Hahm
8. Yufen Zhang
9. Bo Zhang
10. Robert W. Gereau

Reviewed by PREreview

Trial-level Representational Similarity Analysis

1. Shenyang Huang
2. Cortney M Howard
3. Paul C Bogdan
4. Ricardo Morales-Torres
5. Matthew Slayton
6. Roberto Cabeza
7. Simon W Davis

• Curated by eLife

  eLife Assessment

  This study proposes a potentially useful improvement on a popular fMRI method for quantifying representational similarity in brain measurements by focusing on representational strength at the single trial level and adding linear mixed effects modeling for group-level inference. The manuscript provides solid evidence of increased sensitivity with no loss of precision compared to more classic versions of the method. However, several assumptions are insufficiently motivated, and it is unclear to what extent the approach would generalize to other paradigms.

Reviewed by eLife

Characterisation of cold-selective lamina I spinal projection neurons

1. Aimi N Razlan
2. Wenhui Ma
3. Allen C Dickie
4. Erika Polgár
5. Anna McFarlane
6. Mansi Yadav
7. Andrew H Cooper
8. Douglas Strathdee
9. Masahiko Watanabe
10. Andrew M Bell
11. Andrew J Todd
12. Junichi Hachisuka

• Curated by eLife

  eLife Assessment

  This study offers valuable insights into the anatomical and physiological features of cold-selective lamina I spinal projection neurons. The evidence supporting the authors' claims is convincing, although including a larger sample size and more quantification would have strengthened the study, and the claims of monosynaptic connectivity would benefit from being stated more cautiously. The work will interest those in the field of somatosensory biology, especially researchers studying spinal cord dorsal horn circuits and projection neuron cell types.

Reviewed by eLife

Decision-making components and times revealed by the single-trial electro-encephalogram

1. Gabriel Weindel
2. Jelmer P Borst
3. Leendert van Maanen

• Curated by eLife

  eLife Assessment

  Weindel et al examine behavioural and EEG data in an innovative contrast comparison paradigm where they vary mean contrast widely while keeping contrast difference constant. As intended, this allowed an elegant decomposition of processing stages: while sensory encoding shortened with increasing contrast in keeping with Pieron's law, the period of decision formation lengthened, in keeping with Fechner's law, which was applied to drift rates in a diffusion model of that period. This is an important demonstration of how these two laws apply in concert, to two distinct processing levels, and the multivariate topography parsing, mixed effect models and diffusion models are convincing.

Reviewed by eLife

cxcl18b-defined transitional state-specific nitric oxide drives injury-induced Müller glia cell-cycle re-entry in the zebrafish retina

1. Aojun Ye
2. Shuguang Yu
3. Meng Du
4. Dongming Zhou
5. Jie He
6. Chang Chen

• Curated by eLife

  eLife Assessment

  Following retinal injury, zebrafish Müller glia reenter the cell cycle and generate replacement cells; this potentially valuable study proposes that injury induces a cxcl18b+ transitional state in Müller cells, which then express nitric oxide, inhibiting Notch signaling and allowing Müller glial cells to reenter the cell cycle. However, the evidence supporting the claims is incomplete, and the authors have made interpretations and conclusions that are not supported by the data. Questions of the temporal expression and function of cxcl18b, as well as the source of potential inflammatory cues before cxcl18b expression, remain unanswered and technical limitations and data inconsistencies raise concerns. Using larval animals complicates the analysis since the retina is still forming, and distinguishing between injury-induced regeneration and ongoing development is complex. With more rigorous testing of the signaling pathways proposed and a clear demonstration of their interdependence, the link between nitric oxide signaling and Notch activity, particularly, would interest those investigating retinal regeneration.

Reviewed by eLife

DANCE: An open-source analysis pipeline and low-cost hardware to quantify aggression and courtship in Drosophila

1. R Sai Prathap Yadav
2. Paulami Dey
3. Faizah Ansari
4. Tanvi Kottat
5. P Pallavi Prabhu
6. Manohar Vasam
7. Shrinivas Ayyangar
8. Bhaskar S Swathi
9. Krishnananda Prabhu
10. Monalisa Ghosh
11. Pavan Agrawal

• Curated by eLife

  eLife Assessment

  This study presents a valuable open-source and cost-effective method for automating the quantification of male aggression and courtship in Drosophila melanogaster. The work as presented provides solid evidence that the use of the behavioral setup that the authors designed - using readily available laboratory equipment and standardised high-performing classifiers they developed using existing software packages - accurately and reliably characterises social behavior in Drosophila. The work will be of interest to Drosophila neurobiologists and particularly to those working on male social behaviors.

Reviewed by eLife

Continuous flashing suppression of V1 responses and the perceptual consequences revealed via two-photon calcium imaging and transformer modeling

1. Cai-Xia Chen
2. Xin Wang
3. Dan-Qing Jiang
4. Shi-Ming Tang
5. Cong Yu

• Curated by eLife

  eLife Assessment

  This important study shows that orientation tuning of V1 neurons is suppressed during a continuous flash suppression paradigm, especially when the neurons have a binocular receptive field. However, the evidence presented is incomplete and, in particular, does not distinguish whether this suppression is due to reduced contrast or due to masking.

Reviewed by eLife