1. Cntnap2 loss drives striatal neuron hyperexcitability and behavioral inflexibility

    This article has 5 authors:
    1. Katherine R Cording
    2. Emilie M Tu
    3. Hongli Wang
    4. Alexander HCW Agopyan-Miu
    5. Helen S Bateup
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important and well-executed study describes how deleting the autism spectrum disorder risk gene CNTNAP2 in mice increases dorsolateral striatal projection neuron excitability and promotes repetitive behaviors and cognitive inflexibility. The evidence supporting this claim is convincing. The study provides a potential cellular explanation for the repetitive and inflexible behavior in Cntnap2 knockout mice and CNTNAP2 disorder in humans, which would interest both basic and translational neuroscientists.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  2. The novel role of Kallistatin in linking metabolic syndromes and cognitive memory deterioration by inducing amyloid-β plaques accumulation and tau protein hyperphosphorylation

    This article has 14 authors:
    1. Weiwei Qi
    2. Yanlan Long
    3. Ziming Li
    4. Zhen Zhao
    5. Jinhui Shi
    6. Wanting Xie
    7. Laijian Wang
    8. Yandan Tan
    9. Ti Zhou
    10. Minting Liang
    11. Ping Jiang
    12. Bin Jiang
    13. Xia Yang
    14. Guoquan Gao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study identified a molecular mechanism linking diabetes to AD risk and the data presented are convincing. The authors investigated the role of kallistatin in metabolic abnormalities associated with AD and identified that Kallistatin is a key player that mediates Aβ accumulation and tau hyperphosphorylation in AD. This manuscript provides novel insights into the pathogenesis of AD, indicating that the hypolipidemic drug fenofibrate attenuates AD-like pathology in Kallistatin transgenic mice.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  3. Flower/FLWR-1 regulates neuronal activity via the plasma membrane Ca2+-ATPase to promote recycling of synaptic vesicles

    This article has 9 authors:
    1. Marius Seidenthal
    2. Jasmina Redzovic
    3. Jana F Liewald
    4. Dennis Rentsch
    5. Stepan Shapiguzov
    6. Noah Schuh
    7. Nils Rosenkranz
    8. Stefan Eimer
    9. Alexander Gottschalk
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study uses C. elegans to provide new insights into the role of the conserved protein FLWR-1/Flower in synaptic transmission. Employing a variety of techniques, including calcium imaging, ultrastructural analysis, and electrophysiology, the paper provides convincing evidence that challenges some previous thinking about FLWR-1 function. This work will be of particular interest to neuroscientists studying synaptic physiology and plasticity.

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    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
  4. Multiplexed CRISPRi Reveals a Transcriptional Switch Between KLF Activators and Repressors in the Maturing Neocortex

    This article has 5 authors:
    1. Ryan W Kirk
    2. Liwei Sun
    3. Ruixuan Xiao
    4. Erin A Clark
    5. Sacha Nelson
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is an important study utilizing innovative CRISPR based approaches demonstrating the role of the KLF family of transcription factors in the post natal maturation of cortical projection neurons. The strength of evidence overall is compelling, and the study is well executed. The screen data presented provides a number of interesting candidates for future analyses into the mechanism of action of KLF family members in neuronal maturation.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. Esr1-Dependent Signaling and Transcriptional Maturation in the Medial Preoptic Area of the Hypothalamus Shapes the Development of Mating Behavior during Adolescence

    This article has 19 authors:
    1. Koichi Hashikawa
    2. Yoshiko Hashikawa
    3. Brandy Briones
    4. Kentaro Ishii
    5. Yuejia Liu
    6. Mark A Rossi
    7. Marcus L Basiri
    8. Jane Y Chen
    9. Omar R Ahmad
    10. Rishi V Mukundan
    11. Nathan L Johnston
    12. Rhiana C Simon
    13. James C Soetedjo
    14. Jason R Siputro
    15. Jenna A McHenry
    16. Richard D Palmiter
    17. David R Rubinow
    18. Larry S Zweifel
    19. Garret D Stuber
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors test the hypothesis that gonadal steroid signaling influences the transcriptional development of specific neurons in the mPOA during adolescence, and that such adolescent development of the mPOA is necessary for mating behaviors. The findings are valuable and supported by convincing data. This work contributes new insight into hormone-sensitive transcriptional profiles within genetically defined neuron clusters in the mPOA during adolescence and will be of interest to systems and molecular neuroscientists and those interested in development, sex differences, and/or hormonal regulation.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. cxcl18b-defined transitional state-specific nitric oxide drives injury-induced Müller glia cell-cycle re-entry in the zebrafish retina

    This article has 6 authors:
    1. Aojun Ye
    2. Shuguang Yu
    3. Meng Du
    4. Dongming Zhou
    5. Jie He
    6. Chang Chen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Following retinal injury, zebrafish Müller glia reenter the cell cycle and generate replacement cells; this potentially valuable study proposes that injury induces a cxcl18b+ transitional state in Müller cells, which then express nitric oxide, inhibiting notch signaling and allowing Müller glial to reenter the cell cycle. However, the evidence supporting the claims is incomplete; technical limitations and inconsistencies within the data raise concerns. Using larval animals complicates the analysis since the retina is still forming, and distinguishing between injury-induced regeneration and ongoing development is complex. With more rigorous testing of the signaling pathways proposed and a clear demonstration of their interdependence, the link between nitric oxide signaling and Notch activity, particularly, would interest those investigating retinal regeneration.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  7. Affinity-guided labeling reveals P2X7 nanoscale membrane redistribution during microglial activation

    This article has 10 authors:
    1. Benoit Arnould
    2. Adeline Martz
    3. Pauline Belzanne
    4. Francisco Andrés Peralta
    5. Federico Cevoli
    6. Volodya Hovhannisyan
    7. Yannick Goumon
    8. Eric Hosy
    9. Alexandre Specht
    10. Thomas Grutter
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors employ an unbiased, affinity-guided reagent to label P2X7 receptor and use super-resolution imaging to monitor P2X7 redistribution in response to inflammatory signaling. The evidence is generally solid but could be further strengthened through revisions. The study will be valuable to those studying the dynamics of receptor distribution and clustering.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  8. Neural substrates of cold nociception in Drosophila larva

    This article has 3 authors:
    1. Atit A Patel
    2. Albert Cardona
    3. Daniel N Cox
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study investigates neural circuits mediating motor responses to cold in Drosophila larvae. Using a combination of behavioral analysis, genetic manipulations, EM connectomics, and reporters of calcium activity, the authors provide solid evidence that specific sensory and central neurons are required for cold-induced body contraction. This paper may be of interest to neuroscientists interested in how nervous systems sense and respond to cold.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  9. Viral-mediated Oct4 overexpression and inhibition of Notch signaling synergistically induce neurogenic competence in mammalian Müller glia

    This article has 5 authors:
    1. Nguyet Le
    2. Sherine Awad
    3. Isabella Palazzo
    4. Thanh Hoang
    5. Seth Blackshaw
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript demonstrates that Oct4 overexpression synergizes with Notch inhibition (Rbpj knockout) to promote the conversion of adult murine Müller glia (MG) into bipolar cells. These findings are important as the authors used rigorous genetic lineage tracing (GLAST-CreER; Sun-GFP) to confirm that neurogenesis indeed originates from MGs, addressing a key issue in the field. The single-cell multiomic analyses are compelling, and while functional studies of MG-derived bipolar cells would strengthen the conclusions, they are beyond the scope of this study.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  10. A multiplex of connectome trajectories enables several connectivity patterns in parallel

    This article has 10 authors:
    1. Parham Mostame
    2. Jonathan Wirsich
    3. Thomas H Alderson
    4. Ben Ridley
    5. Anne-Lise Giraud
    6. David W Carmichael
    7. Serge Vulliemoz
    8. Maxime Guye
    9. Louis Lemieux
    10. Sepideh Sadaghiani
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work uses an innovative approach to understand similarities between haemodynamic and electrophysiological activity of the human brain, and how the brain might carry out multiple functions concurrently across different brain regions by using multiple timescales. The study provides convincing evidence to indicate that while spatially similar functional brain networks are found in both modalities, there is a tendency for these to occur asynchronously. This work will be of interest to neurophysiological and brain imaging researchers.

    Reviewed by eLife

    This article has 11 evaluationsAppears in 1 listLatest version Latest activity
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