1. Homeostatic Synaptic Plasticity of Miniature Excitatory Postsynaptic Currents in Mouse Cortical Cultures Requires Neuronal Rab3A

    This article has 3 authors:
    1. Andrew G. Koesters
    2. Mark M. Rich
    3. Kathrin L. Engisch
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study presents findings on the role of the small GTPase Rab3A in homeostatic plasticity. While the study provides solid evidence for a requirement of Rab3A in homeostatic up-scaling in cultured mouse neurons, it does not provide a model of how Rab3A is involved in homeostatic plasticity. The work will be of interest to researchers in the field of synaptic transmission and synaptic plasticity.

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    This article has 20 evaluationsAppears in 1 listLatest version Latest activity
  2. Population-level morphological analysis of paired CO2- and odor-sensing olfactory neurons in D. melanogaster via volume electron microscopy

    This article has 7 authors:
    1. Jonathan Choy
    2. Shadi Charara
    3. Kalyani Cauwenberghs
    4. Quintyn McKaughan
    5. Keun-Young Kim
    6. Mark Ellisman
    7. Chih-Ying Su
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable work uses serial block face electron microscopy to reconstruct detailed morphologies of large populations of Drosophila sensory neurons to determine the degree of diversity both within and across distinct neuronal populations. The authors convincingly show that there is considerable morphological diversity even within classes, and develop testable hypotheses about how arbors are optimized for particular sensory function and physiology. This work will be of interest to biologists working in physiology, insect chemosensation, and neuroscience.

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  3. The information bottleneck as a principle underlying multi-area cortical representations during decision-making

    This article has 10 authors:
    1. Michael Kleinman
    2. Tian Wang
    3. Derek Xiao
    4. Ebrahim Feghhi
    5. Kenji Lee
    6. Nicole Carr
    7. Yuke Li
    8. Nima Hadidi
    9. Chandramouli Chandrasekaran
    10. Jonathan C Kao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This manuscript reports a useful computational study of information encoding across the monkey prefrontal and pre-motor cortices during decision making. While many of the conclusions are supported with solid analyses, the evidence for the main interpretation of the results, the role of an information bottleneck across areas, is not complete. The results will be of interest to a systems and computational neuroscience audience.

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    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  4. Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation

    This article has 5 authors:
    1. Yanshu Wang
    2. Amir Rattner
    3. Zhongming Li
    4. Philip M Smallwood
    5. Jeremy Nathans
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Endothelial cell-specific loss of TGF-beta signaling in mice leads to CNS vascular defects, specifically impairing retinal development and promoting immune cell infiltration. The data are solid, showing that loss of TGF-beta signaling triggers vascular inflammation and attracts immune cells specific to CNS vasculature, but there are issues with the single-nucleus RNA sequencing of immune cells. These findings are valuable, highlighting TGF-beta's role in maintaining vascular-immune homeostasis and its therapeutic potential in neurovascular inflammatory diseases.

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    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  5. A geometric shape regularity effect in the human brain

    This article has 8 authors:
    1. Mathias Sablé-Meyer
    2. Lucas Benjamin
    3. Cassandra Potier Watkins
    4. Chenxi He
    5. Maxence Pajot
    6. Thoé Morfoisse
    7. Fosca Al Roumi
    8. Stanislas Dehaene
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study provides converging results from complementary neuroimaging and behavioral experiments to identify human brain regions involved in representing regular geometric shapes. Geometric shape concepts are universally present across diverse human cultures and possibly essential for unique human capabilities such as numerical cognition and symbolic reasoning, and identifying the brain networks involved in geometric shape representation is of broad interest to researchers studying human visual perception, reasoning, and cognitive development. The provided experimental evidence regarding the presence of geometric shape regularity representation in dorsal parietal and prefrontal cortex is solid, but the claimed link with mathematical reasoning, the influence of experimental tasks, and the role of experience in driving geometric shape representation in both humans and artificial vision models require further elucidation.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. Decoding the Cognitive map: Learning place cells and remapping

    This article has 4 authors:
    1. Markus Borud Pettersen
    2. Vemund Sigmundson Schøyen
    3. Anders Malthe-Sørenssen
    4. Mikkel Elle Lepperød
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This useful modeling study shows how spatial representations, similar to those seen in experimental data, emerge in a recurrent neural network trained on a navigation task. The training required path integration and decodability but did not rely on grid cell inputs. The network modeling is solid, though the link to experimental data could be strengthened.

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    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  7. Guardian of Excitability: Multifaceted Role of Galanin in Whole Brain Excitability

    This article has 4 authors:
    1. Nicolas N Rieser
    2. Milena Ronchetti
    3. Adriana L Hotz
    4. Stephan CF Neuhauss
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The study investigated the effects of the peptide galanin on brain Ca2+ activity in zebrafish, which provides a useful model organism for whole-brain imaging because of its transparency. They found that galanin has distinct effects on hyperactivity and expression of galanin changes after activity increases. The strength of evidence was incomplete particularly for some of the conclusions regarding the use of convulsants and relevance to epilepsy because of limitations to the methods and interpretations of results.

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    This article has 15 evaluationsAppears in 1 listLatest version Latest activity
  8. Synaptic Connectivity of Sensorimotor Circuits for Vocal Imitation in the Songbird

    This article has 6 authors:
    1. Massimo Trusel
    2. Ziran Zhao
    3. Danyal H Alam
    4. Ethan S Marks
    5. Maaya Z Ikeda
    6. Todd F Roberts
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The songbird vocal motor nucleus HVC contains cells that project to the basal ganglia, the auditory system, or to downstream vocal motor structures. In this fundamental study, the authors conduct optogenetic circuit mapping to clarify how four distinct inputs to HVC act on these distinct HVC cell types. They provide compelling evidence that all long range projections engage inhibitory circuits in HVC and can also exhibit cell-type specific preferences in monosynpatic input strength. Understanding HVC at this microcircuit level is critical for constraining models of song learning and production.

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    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  9. Microglia are Required for Developmental Specification of AgRP Innervation in the Hypothalamus of Offspring Exposed to Maternal High-Fat Diet During Lactation

    This article has 4 authors:
    1. Haley N. Mendoza-Romero
    2. Jessica E. Biddinger
    3. Michelle N. Bedenbaugh
    4. Richard B. Simerly
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors provide a valuable contribution by documenting the role of microglia in pruning the axon terminals of AgRP neurons. The analysis of microglial axonal pruning is solid; however, the analysis of the effects inhibiting microglia on subsequent food consumption is not fully complete.

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    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  10. Disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar output

    This article has 6 authors:
    1. Nirvik Sinha
    2. Sharon Israely
    3. Ora Ben Harosh
    4. Ran Harel
    5. Julius PA Dewald
    6. Yifat Prut
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Using a unique cerebellar disruption approach in non-human primates, this study provides valuable new insight into how cerebellar inputs to the motor cortex contribute to reaching. The findings convincingly demonstrate that reaching movements following cerebellar disruption slow down because of both an acute deficit in producing muscle activity as well as a progressive decline in compensating for limb dynamics. This work will be of interest to neuroscientists and clinicians interested in cerebellar function and pathology.

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    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
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