Neuroscience

PRRT2 as an auxiliary regulator of Nav channel slow inactivation

1. Bin Lu
2. Qi-Wu Xu
3. Jing Zhang
4. Xue-Mei Wu
5. Jun-Yan He
6. Guang Yang
7. Ke-Xian Li
8. Ling Zhuang
9. Yu-Xian Zhang
10. Zhi-Qi Xiong

• Curated by eLife

  eLife Assessment

  This important study identifies PRRT2 as an auxiliary regulator of Nav channel slow inactivation, proposing that PRRT2 facilitates entry into, and delays recovery from, the slow-inactivated state. The evidence provided is compelling and well executed, though the work would be bolstered by additional studies of Nav1.6, as well as structural studies to directly investigate the molecular basis of gating modulation. Overall, this study will be of interest to ion channel biophysicists and neurophysiologists, particularly those studying channelopathies.

Reviewed by eLife

Inflammatory reprogramming of human brain endothelial cells compromises blood–brain barrier integrity in Alzheimer’s disease

1. Rebecca L. Pinals
2. Md Rezaul Islam
3. Oisín King
4. Aaron Choi
5. Eulim Kang
6. Masayuki Nakano
7. Anjanet Tuyéras
8. Maeesha Tasnim Naomi
9. Arthur Ngo
10. Alan Jiang
11. Nhat Truong
12. Emre Agbas
13. Claudia F. Lozano Cruz
14. Colin Staab
15. Tak Ko
16. David A. Bennett
17. Alice E. Stanton
18. Robert Langer
19. Li-Huei Tsai

Reviewed by PREreview

Experience shapes the transformation of olfactory representations along the cortico-hippocampal pathway

1. Eleonore Schiltz
2. Martijn Broux
3. Cagatay Aydin
4. Pedro Goncalves
5. Sebastian Haesler

• Curated by eLife

  eLife Assessment

  This important study describes the progressive transformation of olfactory information across five different brain regions in the olfactory pathway, including a comparison of responses to familiar and unfamiliar odors. This dataset is of broad interest for olfactory researchers and provides a solid analysis of a graded change in representations of odor identity and experience in different locations in the pathway.

Reviewed by eLife

Feedback of peripheral saccade targets to early foveal cortex

1. Luca Kämmer
2. Lisa M Kroell
3. Tomas Knapen
4. Martin Rolfs
5. Martin N Hebart

• Curated by eLife

  eLife Assessment

  This valuable study addresses a question related to how we achieve visual stability across saccadic eye movements. The authors' gaze-contingent fMRI design provides convincing evidence that peripherally presented visual stimuli are represented in foveal visual cortex prior to a saccade. The results will be of interest to vision scientists and behavioural neuroscientists.

Reviewed by eLife

Pupil dilation offers a time-window on prediction error

1. Olympia Colizoli
2. Tessa van Leeuwen
3. Danaja Rutar
4. Harold Bekkering

• Curated by eLife

  eLife Assessment

  This valuable study investigates the relationship between pupil dilation and information gain during associative learning, using two different tasks. A key strength of this study is its exploration of pupil dilation beyond the immediate response period, extending analysis to later time windows after feedback, and it provides convincing evidence that pupillary response to information gain may be context-dependent during associative learning. The interpretation remains limited by task heterogeneity and unresolved contextual factors influencing pupil dynamics, but a range of interesting ideas are discussed.

Reviewed by eLife

High-Fidelity Neural Speech Reconstruction through an Efficient Acoustic-Linguistic Dual-Pathway Framework

1. Jiawei Li
2. Chunxu Guo
3. Chao Zhang
4. Edward F Chang
5. Yuanning Li

• Curated by eLife

  eLife Assessment

  This study presents a valuable advance in reconstructing naturalistic speech from intracranial ECoG data using a dual-pathway model. The evidence supporting the claims of the authors is solid, although the rationale for employing a smaller language model rather than a large language model (LLM) should be further clarified. This work will be of interest to cognitive neuroscientists and computer scientists/engineers working on speech reconstruction from neural data.

Reviewed by eLife

Neural activity profiles reveal overlapping, intermingled subpopulations spanning area borders in mouse sensorimotor cortex

1. Sohrab Salimian
2. Harrison A Grier
3. Matthew T Kaufman

• Curated by eLife

  eLife Assessment

  This fundamental study provides compelling evidence for the functional segregation of the sensorimotor cortex into precisely delineated areas, and highlights a rapid transition in functional properties at the boundaries between these areas. This result further confirms and extends recent work on the diversity of neural response specificities across cortical areas in the context of complex behavioral tasks. This work will be of interest to neuroscientists studying sensory-motor functions.

Reviewed by eLife

Grid cells encode reward distance during path integration in cue-rich environments

1. Satoshi Kuroki
2. Sébastien Royer

Reviewed by PREreview

Context-dependent presynaptic inhibition of somatostatin interneuron inputs to Layer 1 of the visual cortex

1. Mansour Alyahyay
2. Dimitri Dumontier
3. Deyl S. Djama
4. Morris Jackson
5. Abdullah Lugtum
6. Edenia C Menezes
7. Haojie Ye
8. Jun Chen Qian
9. Giulia Sansone
10. Mohammed Soheib
11. Andrea M.C. Mirow
12. Leena Ali Ibrahim
13. Gabrielle Pouchelon

Reviewed by PREreview

Brain-derived estrogens facilitate male-typical behaviors by potentiating androgen receptor signaling in medaka

1. Yuji Nishiike
2. Shizuku Maki
3. Daichi Miyazoe
4. Kiyoshi Nakasone
5. Yasuhiro Kamei
6. Takeshi Todo
7. Tomoko Ishikawa-Fujiwara
8. Kaoru Ohno
9. Takeshi Usami
10. Yoshitaka Nagahama
11. Kataaki Okubo

• Curated by eLife

  eLife Assessment

  This is an overall compelling set of findings on the role of centrally produced estrogens in the control of behaviors in male medaka. The significance of the findings rests on the revealed potential mechanism between brain derived estrogens modulating social behaviors in males , supported by the analysis of multiple transgenic lines. The evidence for the broader claim is incomplete since it has not been extended to female medaka, and further experimentation would be necessary to fully validate the conclusions on the role of brain-derived estrogens. Nonetheless, the findings have led to important hypotheses on the hormonal control of behaviors in teleosts that can be tested further.

Reviewed by eLife