1. Neural basis of cognitive control signals in anterior cingulate cortex during delay discounting

    This article has 8 authors:
    1. Jeremy K Seamans
    2. Shelby White
    3. Mitchell Morningstar
    4. Eldon Emberly
    5. David Linsenbardt
    6. Baofeng Ma
    7. Cristine L Czachowski
    8. Christopher C Lapish
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors studied cognitive control signals in the anterior cingulate cortex (ACC) while rats selected between small immediate and larger delayed rewards. The description of behavioral strategies related to value-tracking signals in ACC is potentially useful. The evidence in support of this finding is incomplete due to issues with the task design, analyses, and modeling.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  2. Characterisation of cold-selective lamina I spinal projection neurons

    This article has 12 authors:
    1. Aimi N Razlan
    2. Wenhui Ma
    3. Allen C Dickie
    4. Erika Polgár
    5. Anna McFarlane
    6. Mansi Yadav
    7. Andrew H Cooper
    8. Douglas Strathdee
    9. Masahiko Watanabe
    10. Andrew M Bell
    11. Andrew J Todd
    12. Junichi Hachisuka
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study offers valuable insights into the anatomical and physiological features of cold-selective lamina I spinal projection neurons. The evidence supporting the authors' claims is compelling, although including a larger sample size and more quantification would have strengthened the study further, and the claims of monosynaptic connectivity would benefit from being stated more cautiously. The work will interest those in the field of somatosensory biology, especially researchers studying spinal cord dorsal horn circuits and projection neuron cell types.

    Reviewed by eLife

    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
  3. Linear and categorical coding units in the mouse gustatory cortex drive population dynamics and behavior in taste decision-making

    This article has 5 authors:
    1. Liam Lang
    2. Camelia Yuejiao Zheng
    3. Jennifer M Blackwell
    4. Giancarlo La Camera
    5. Alfredo Fontanini
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work advances our understanding of the single neuron coding types in the mouse gustatory cortex and the functional roles of these neurons for perceptual decision-making. The conclusions are based on compelling evidence from rigorous behavioral experiments, high-density electrophysiology, sophisticated data analysis, and neural network modeling with in silico perturbations of functionally-identified units. This work will be of broad interest to systems neuroscientists.

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    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  4. Reactivation-coupled brain stimulation enables complete learning generalization

    This article has 8 authors:
    1. Yibo Xie
    2. Minmin Wang
    3. Yuan Gao
    4. Baoyu Wu
    5. Shaomin Zhang
    6. Mengyuan Gong
    7. Zoe Kourtzi
    8. Ke Jia
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study shows that combining reactivation-based training with anodal tDCS yields an unusually broad generalization of visual perceptual learning, while preserving robust learning gains and markedly reducing total training time. Although the empirical evidence is solid, the proposed mechanistic account, i.e., the GABA modulation, disrupted offline consolidation and reduced perceptual overfitting, remains insufficiently substantiated, as these assumptions lack direct neurochemical support, and several alternative behavioral explanations and necessary control comparisons have not been fully addressed. The work will be of broad interest to researchers investigating brain plasticity, perceptual learning, and rehabilitation training.

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    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. Complimentary vertebrate Wac models exhibit phenotypes relevant to DeSanto-Shinawi Syndrome

    This article has 23 authors:
    1. Kang-Han Lee
    2. April M Stafford
    3. Maria Pacheco-Vergara
    4. Karol Cichewicz
    5. Cesar P Canales
    6. Nicolas Seban
    7. Melissa Corea
    8. Darlene Rahbarian
    9. Kelly E. Bonekamp
    10. Grant R. Gillie
    11. Dariangelly Pacheco Cruz
    12. Alyssa M Gill
    13. Hye-Eun Hwang
    14. Katie L Uhl
    15. Tara E Jager
    16. Marwan Shinawi
    17. Xiaopeng Li
    18. Andre Obenaus
    19. Shane Crandall
    20. Juhee Jeong
    21. Alex Nord
    22. Cheol-Hee Kim
    23. Daniel Vogt
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study establishes the first vertebrate models of DeSanto-Shinawi Syndrome, revealing conserved craniofacial and social and behavioral phenotypes across mouse and zebrafish that mirror key clinical features. The solid evidence is supported by behavioral, anatomical, and molecular analyses of Wac animal mutants that broadly support the authors' claims, though additional mechanistic investigation would strengthen the conclusions. This study sets a baseline for future mechanistic studies and reports a platform to test approaches to reverse phenotypes.

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    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  6. Verbal Episodic Processing in Newborns

    This article has 4 authors:
    1. Emma Visibelli
    2. Ana Fló
    3. Eugenio Baraldi
    4. Silvia Benavides-Varela
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This fundamental study reports solid evidence for early verbal episodic memory formation. The findings demonstrate that speaker identity is a crucial feature, enabling episodic-like memories from birth, and will be of interest to cognitive neuroscientists working on brain development, memory, language learning and social cognition.

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    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  7. Spectral decomposition of local field potentials uncovers frequency-tuned gain modulation of working memory in primate visual system

    This article has 5 authors:
    1. Majid Roshanaei
    2. Mohammad Reza Daliri
    3. Zahra Bahmani
    4. Kelsey Clark
    5. Behrad Noudoost
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study offers a valuable contribution to understanding how working memory (WM) shapes neural processing in extrastriate cortex. By applying spectral decomposition to LFP recordings from primate middle temporal area (MT) during a spatial WM task, the authors show that lower-frequency components (theta, alpha, and beta, but not gamma or high-gamma) correlate with trial-by-trial gain modulation of visually evoked responses. However, certain aspects of the gain-modulation and statistical analyses are incomplete. A clearer and more comprehensive description of these components would substantially strengthen the manuscript.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  8. Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy

    This article has 14 authors:
    1. Eric R Wengert
    2. Sophie R Liebergall
    3. Teresa Jimenez
    4. Melody A Cheng
    5. Kelly H Markwalter
    6. Jerome Clatot
    7. Yerahm Hong
    8. Leroy Arias
    9. Eric D Marsh
    10. Xiaohong Zhang
    11. Theodoros Tsetsenis
    12. Ala Somarowthu
    13. Naiara Akizu
    14. Ethan M Goldberg
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides important evidence for the mechanism underlying KCNC1-related developmental and epileptic encephalopathy. The authors have generated and characterized a new knock-in mouse with a pathogenic mutation found in patients to determine the synaptic and circuit mechanisms contributing to KCNC1-associated epilepsy. They provide convincing evidence for reduced excitability of parvalbumin-positive fast-spiking interneurons, but not in neighboring excitatory neurons, and suggest that this may contribute to seizures and premature death in the mice.

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    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  9. Barcode activity in a recurrent network model of the hippocampus enables efficient memory binding

    This article has 5 authors:
    1. Ching Fang
    2. Jack Lindsey
    3. Larry F Abbott
    4. Dmitriy Aronov
    5. Selmaan Chettih
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This fundamental work substantially advances our understanding of episodic memory by proposing a biologically plausible mechanism through which hippocampal barcode activity enables efficient memory binding and flexible recall. The evidence supporting the conclusions is convincing, with rigorously validated computational models and alignment with experimental findings. The work will be of broad interest to neuroscientists and computational modelers studying memory and hippocampal function.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  10. WAChRs are excitatory opsins sensitive to indoor lighting

    This article has 5 authors:
    1. Amanda J. Tose
    2. Alberto A. Nava
    3. Sara N. McGrath
    4. Alan R. Mardinly
    5. Alexander Naka

    Reviewed by PREreview, Arcadia Science

    This article has 3 evaluationsAppears in 2 listsLatest version Latest activity
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