Neuroscience

Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of Fragile X syndrome

1. Huei Bin Wang
2. Natalie E Smale
3. Sarah H Brown
4. Sophia Anne Marie B Villanueva
5. David Zhou
6. Aly Mulji
7. Deap S Bhandal
8. Kyle Nguyen-Ngo
9. John R Harvey
10. Cristina A Ghiani
11. Christopher S Colwell

• Curated by eLife

  eLife Assessment

  This manuscript presents solid experimental data using Fmr1 knockout mice to explore the fundamental role of Fmr1 in sleep regulation. The study supports the hypothesis that scheduled feeding can improve circadian rhythm and behavior in a mouse model of Fragile X syndrome. These findings may offer new insights into neurodevelopmental disorders and their potential treatment strategies.

Reviewed by eLife

Preparatory attentional templates in prefrontal and sensory cortex encode target-associated information

1. Zhiheng Zhou
2. Joy J Geng

• Curated by eLife

  eLife Assessment

  This important study decoded target-associated information in prefrontal and sensory cortex during the preparatory period of a visual search task, suggesting a memory component of human subjects performing such visual attention task. The evidence supporting this claim is compelling, based on multivariate pattern analyses of fMRI data. The results will be of interest to psychologists and cognitive neuroscientists.

Reviewed by eLife

Alternatives to Friction Coefficient: Fine Touch Perception Relies on Frictional Instabilities

1. Maryanne Derkaloustian
2. Pushpita Bhattacharyya
3. Truc Ngo
4. Joshua GA Cashaback
5. Jared Medina
6. Charles B Dhong

• Curated by eLife

  eLife Assessment

  This useful study integrates experimental methods from materials science with psychophysical methods to investigate how frictional stabilities influence tactile surface discrimination. The authors argue that force fluctuations arising from transitions between frictional sliding conditions facilitate the discrimination of surfaces with similar friction coefficients. However, the reliance on friction data from an artificial finger, combined with correlational analyses that fall short of establishing a mechanistic link to perception, renders the findings incomplete.

Reviewed by eLife

Decoding movie content from neuronal population activity in the human medial temporal lobe

1. Franziska Gerken
2. Alana Darcher
3. Pedro J Gonçalves
4. Rachel Rapp
5. Ismail Elezi
6. Johannes Niediek
7. Marcel S Kehl
8. Thomas P Reber
9. Stefanie Liebe
10. Jakob H Macke
11. Florian Mormann
12. Laura Leal-Taixé

• Curated by eLife

  eLife Assessment

  This valuable study demonstrates that it is possible to decode information about characters and locations from single-unit responses in the human brain to a narrative movie, using a convincing technical approach to capture information in population-level dynamics. The study introduces an exciting dataset of single-unit responses in humans during a naturalistic and dynamic movie stimulus, with recordings from multiple regions within the medial temporal lobe. Using both a traditional firing-rate analysis as well as a population decoding analysis to connect these neural responses to the visual content of the movie, they show that in this dataset, the decoding of semantic scene features (e.g., the person currently on screen), but not scene transitions, is surprisingly driven by classically non-responsive neurons. Based on these findings, the authors argue that dynamic naturalistic semantic information may be processed within the medial temporal lobe at the population level.

Reviewed by eLife

Maintenance of neuronal TDP-43 expression requires axonal lysosome transport

1. Veronica H Ryan
2. Sydney Lawton
3. Joel F Reyes
4. James Hawrot
5. Ashley M Frankenfield
6. Sahba Seddighi
7. Daniel M Ramos
8. Jacob Epstein
9. Faraz Faghri
10. Nicholas L Johnson
11. Jizhong Zou
12. Martin Kampmann
13. John Replogle
14. Yue A Qi
15. Hebao Yuan
16. Kory R Johnson
17. Dragan Maric
18. Ling Hao
19. Mike A Nalls
20. Michael E Ward

• Curated by eLife

  eLife Assessment

  In this important manuscript, Ryan et al perform a genome-wide CRISPR based screen to identify genes that modulate TDP-43 levels in neurons. They identify a number of genes and pathways and highlight the BORC complex, which is required for anterograde lysosome transport as one such regulator of TDP-43 protein levels. Overall, this is a convincing study, which opens the door for additional future investigations on the regulation of TDP-43.

Reviewed by eLife, PREreview

iGABASnFR2: Improved genetically encoded protein sensors of GABA

1. Ilya Kolb
2. Jeremy P. Hasseman
3. Akihiro Matsumoto
4. Thomas P. Jensen
5. Olga Kopach
6. Benjamin J. Arthur
7. Yan Zhang
8. Arthur Tsang
9. Daniel Reep
10. Getahun Tsegaye
11. Jihong Zheng
12. Ronak H. Patel
13. Loren L. Looger
14. Jonathan S. Marvin
15. Wyatt L. Korff
16. Dmitri A. Rusakov
17. Keisuke Yonehara
18. GENIE Project Team
19. Glenn C. Turner

Reviewed by PREreview

Efficient Generation of Expandable Dorsal Forebrain Neural Rosette Stem Cell Lines

1. Signe Emilie Dannulat Frazier
2. Kristian Honnens de Lichtenberg
3. Elham Jaberi
4. Charlotte Bertelsen
5. Simone Møller Jensen
6. Andreas Wrona
7. Nicolaj Strøyer Christophersen
8. Mie Kristensen
9. J Carlos Villaescusa

• Curated by eLife

  eLife Assessment

  The study provides valuable technical advances to generate and isolate neural rosettes. The technique is robust, as indicated by both reviewers. The evidence is solid, as shown in orthogonal characterization by flow cytometry, morphology, and scRNA-seq. Comparison with the manual-rosette-picking protocol will enhance the validity of the claims.

Reviewed by eLife

Policy shaping based on the learned preferences of others accounts for risky decision-making under social observation

1. HeeYoung Seon
2. Dongil Chung

• Curated by eLife

  eLife Assessment

  Seon and Chung investigate changes in own risk-taking behavior, when they are being observed by a "risky" or "safe" player. Using computational modeling and model-informed fMRI, the authors present convincing evidence that participants adjust their choice congruent with the other player's type (either risky or safe). The conclusions of the paper are an important contribution to the field of social decision-making as they show a differentiated adjustment of choices and not just a universally riskier choice behavior when being observed as has been claimed in previous studies.

Reviewed by eLife

The unique synaptic circuitry of specialized olfactory glomeruli in Drosophila melanogaster

1. Lydia Gruber
2. Rafael Cantera
3. Markus William Pleijzier
4. Michael Steinert
5. Thomas Pertsch
6. Bill S Hansson
7. Jürgen Rybak

• Curated by eLife

  eLife Assessment

  This study seeks to determine how synaptic relationships between principal cell types in the olfactory system vary with glomerulus selectivity and is therefore valuable to the field. The methodology is solid, and with the caveat that here was a technical need to group all local interneurons, centrifugal neurons and multiglomerular projection neurons into one category ("multiglomerular neurons"), this work reveals some very interesting potential differences in circuit architecture associated with glomerular tuning breadth.

Reviewed by eLife, preLights

Intrinsic Resistance of the Hippocampal CA2 Subfield to Neuroinflammation After Status Epilepticus

1. Bruno Ponciano Da silva
2. Edna Cristina Santos Franco
3. Silene Maria Araújo de Lima

Reviewed by PREreview