Neuroscience

Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain

1. Tom Bonnifet
2. Sandra Sinnassamy
3. Olivia Massiani-Beaudoin
4. Philippe Mailly
5. Héloïse Monnet
6. Damarys Loew
7. Berangère Lombard
8. Nicolas Servant
9. Rajiv L Joshi
10. Julia Fuchs

• Curated by eLife

  eLife assessment

  Bonnifet et al. present data on the expression and interacting partners of the transposable element L1 in the mammalian brain. The work includes important findings addressing the potential role of L1 in aging and neurodegenerative disease. However, several aspects of experimental evidence presented are preliminary and the study remains incomplete in its current form.

Reviewed by eLife

Beyond Auditory Relay: Dissecting the Inferior Colliculus’s Role in Sensory Prediction, Cognitive Decision-Making, and Reward Prediction

1. Xinyu Du
2. Haoxuan Xu
3. Peirun Song
4. Yuying Zhai
5. Hangting Ye
6. Xuehui Bao
7. Qianyue Huang
8. Hisashi Tanigawa
9. Zhiyi Tu
10. Pei Chen
11. Xuan Zhao
12. Josef P Rauschecker
13. Xiongjie Yu

• Curated by eLife

  eLife assessment

  This study presents a valuable finding on the role of the Inferior Colliculus in sensory prediction, cognitive decision-making, and reward prediction. The evidence supporting the claims of the authors is solid. The work will be of interest to neurobiologists working on auditory processing.

Reviewed by eLife

Aminergic and peptidergic modulation of Insulin-Producing Cells in Drosophila

1. Martina Held
2. Rituja S. Bisen
3. Meet Zandawala
4. Alexander S. Chockley
5. Isabella S. Balles
6. Selina Hilpert
7. Sander Liessem
8. Federico Cascino-Milani
9. Jan M. Ache

• Curated by eLife

  eLife assessment

  The fruit fly brain hosts neurosecretory neurons (Insulin Producing Cells or IPCs) that integrate many inputs and release insulin directly into the hemolymph. In this fundamental study, the population of IPCs are shown to be heterogeneous in their receptor diversity, exhibiting a range of responses to neuromodulation. The authors convincingly demonstrate, using a battery of experimental techniques and relying on the mapped whole brain connectome, how the heterogeneity in the responses across individual IPCs occur simultaneously and together modulate insulin release to maintain metabolic homeostasis. This work will be of interest to neuroscientists and physiologists, in particular for how cellular diversity results in a better control of homeostasis in short time scales.

Reviewed by eLife

Connectome-Based Attractor Dynamics Underlie Brain Activity in Rest, Task, and Disease

1. Robert Englert
2. Balint Kincses
3. Raviteja Kotikalapudi
4. Giuseppe Gallitto
5. Jialin Li
6. Kevin Hoffschlag
7. Choong-Wan Woo
8. Tor D Wager
9. Dagmar Timmann
10. Ulrike Bingel
11. Tamas Spisak

• Curated by eLife

  eLife assessment

  This study presents a useful approach for revealing large-scale brain attractor dynamics during resting states, task processing, and disease conditions using insights from Hopfield neural networks. The evidence supporting the findings is solid across the many datasets analysed. The work will be of broad interest to neuroscientists using neuroimaging data with interest in computational modelling of brain activity.

Reviewed by eLife

Drosulfakinin signaling encodes early-life memory for adaptive social plasticity

1. Jiwon Jeong
2. Kujin Kwon
3. Terezia Klaudia Geisseova
4. Jongbin Lee
5. Taejoon Kwon
6. Chunghun Lim

Reviewed by Review Commons

The subthalamic nucleus contributes causally to perceptual decision-making in monkeys

1. Kathryn Rogers
2. Joshua I Gold
3. Long Ding

• Curated by eLife

  eLife assessment

  The fundamental study by Ding and colleagues identifies subpopulations of neurons recorded in the monkey subthalamic nucleus (STN) with distinct activity profiles and causal contributions during perceptual decision-making. The combination of neuronal recording, microstimulation, and computational methods provides convincing evidence for a heterogenous neural population that could support multifaceted roles in decision formation. This study should be of wide interest to computational and experimental neuroscientists interested in cognitive function.

Reviewed by eLife

Flexible neural representations of abstract structural knowledge in the human Entorhinal Cortex

1. Shirley Mark
2. Phillipp Schwartenbeck
3. Avital Hahamy
4. Veronika Samborska
5. Alon B Baram
6. Timothy E Behrens

• Curated by eLife

  eLife assessment

  Mark and colleagues developed and validated a valuable method for examining subspace generalization in fMRI data and applied it to understand whether the entorhinal cortex uses abstract representations that generalize across different environments with the same structure. Evidence supporting the empirical findings - which show abstract entorhinal representations of hexagonal associative structures across different stimulus sets - is solid but could be further supported through additional analyses, discussion, and clarifications.

Reviewed by eLife

Rabphilin-3A negatively regulates neuropeptide release, through its SNAP25 interaction

1. Adlin Abramian
2. Rein I Hoogstraaten
3. Fiona H Murphy
4. Kathryn F McDaniel
5. Ruud F Toonen
6. Matthijs Verhage

• Curated by eLife

  eLife assessment

  This important study advances our understanding of the mechanisms of neuronal large dense-core vesicle (LDCV) secretion, which mediates neuropeptide and neurotrophin release. It describes a negative regulatory process involving the interaction of the Rab3-effector Rabphilin-3A with the SNARE fusion protein SNAP25, which limits LDCV secretion and neurite growth. The evidence in support of the authors' claims is generally convincing, but some conclusions, e.g regarding the role of Rabphilin-3A-controlled neurotrophin signaling in neurite growth, are incompletely supported. This study will be of interest to the fields of cell biology, cellular neuroscience, and neuroendocrinology.

Reviewed by eLife

Natural forgetting reversibly modulates engram expression

1. James D O’Leary
2. Rasmus Bruckner
3. Livia Autore
4. Tomás J Ryan

• Curated by eLife

  eLife assessment

  This is an important paper on the role of engrams and relevant conditions that influence memory and forgetting. The variety of methods used, namely, behavioural, labeling, interrogation, immunohistochemistry, microscopy, pharmacology, computational, are exemplary and provide convincing evidence for the role of engrams in the dentate gyrus in memory retrieval and forgetting. This examination will be of interest broadly across behavioural and neural science communities.

Reviewed by eLife

Multisensory integration operates on correlated input from unimodal transients channels

1. Cesare V Parise
2. Marc O Ernst

• Curated by eLife

  eLife assessment

  This important study evaluates a model for multisensory correlation detection, focusing on the detection of correlated transients in visual and auditory stimuli. Overall, the experimental design is sound and the evidence is compelling. The synergy between the experimental and theoretical aspects of the paper is strong, and the work will be of interest to both neuroscientists and psychologists working in the domain of sensory processing and perception.

Reviewed by eLife