Neuroscience

Programmed Cell Death Modifies Neural Circuits and Tunes Intrinsic Behavior

1. Alison Kochersberger
2. Dongyeop Lee
3. Mohammad Mahdi Torkashvand
4. Sandeep Kumar
5. Saba Baskoylu
6. Titas Sengupta
7. Noelle Koonce
8. Chloe E. Emerson
9. Nandan V. Patel
10. Daniel Colón-Ramos
11. Steven Flavell
12. Andrew M. Leifer
13. Vivek Venkatachalam
14. H. Robert Horvitz
15. Marc Hammarlund

Reviewed by Review Commons

Patient-Specific Midbrain Organoids with CRISPR Correction Recapitulate Neuronopathic Gaucher Disease Phenotypes and Enable Evaluation of Novel Therapies

1. Yi Lin
2. Benjamin Liou
3. Venette Fannin
4. Stuart Adler
5. Christopher N Mayhew
6. Jason E Hammonds
7. Yueh-Chiang Hu
8. Jason Tchieu
9. Wujuan Zhang
10. Xueheng Zhao
11. Rebecca L Beres
12. Kenneth DR Setchell
13. Ahmet Kaynak
14. Xiaoyang Qi
15. Ricardo A Feldman
16. Ying Sun

• Curated by eLife

  eLife Assessment

  This study provides potentially important insights by establishing a human disease model and exploring therapeutic approaches. The evidence is generally convincing for descriptive and comparative findings. The authors present solid data, but evidence for proposed biological mechanisms and functional outcomes remains limited.

Reviewed by eLife

Characterisation of cold-selective lamina I spinal projection neurons

1. Aimi N Razlan
2. Wenhui Ma
3. Allen C Dickie
4. Erika Polgár
5. Anna McFarlane
6. Mansi Yadav
7. Andrew H Cooper
8. Douglas Strathdee
9. Masahiko Watanabe
10. Andrew M Bell
11. Andrew J Todd
12. Junichi Hachisuka

• Curated by eLife

  eLife Assessment

  This important study offers insights into the anatomical and physiological features of cold-selective lamina I spinal projection neurons. The evidence supporting the authors' claims is convincing, although including a larger sample size and more quantification would have strengthened the study, and the claims of monosynaptic connectivity would benefit from further experimental evidence. The work will interest those in the field of somatosensory biology, especially researchers studying spinal cord dorsal horn circuits and projection neuron cell types

Reviewed by eLife

The Locomoting State Selectively Amplifies Activity of Sensitizing Neurons in Primary Visual Cortex

1. Antonio J Hinojosa
2. Yehor Kosiachkin
3. Sina E Dominiak
4. Benjamin D Evans
5. Leon Lagnado

• Curated by eLife

  eLife Assessment

  This manuscript presents a valuable analysis of how locomotion modulates the activity of different subtypes of cortical neurons in the mouse primary visual cortex, showing that locomotion more strongly increases responses in sensitizing than in depressing excitatory cells. This data is then used to constrain a model of the responses. While the data are very interesting, the analyses remain incomplete, in particular due to concerns surrounding the modelling.

Reviewed by eLife

Consciously detecting and recognizing a past visual word after its sensory trace is gone

1. Daphné Rimsky Robert
2. Matteo Lisi
3. Kevin Nguy
4. Roxane Jannin
5. Thomas Hardy
6. Nathan Beraud
7. Claire Sergent

Reviewed by preLights

Trial-by-trial inter-areal interactions in visual cortex in the presence or absence of visual stimulation

1. Dianna Hidalgo
2. Giorgia Dellaferrera
3. Giordano Ramos-Traslosheros
4. Will Xiao
5. Carlos R Ponce
6. Maria Papadopouli
7. Stelios Smirnakis
8. Gabriel Kreiman

• Curated by eLife

  eLife Assessment

  This study investigates trial-by-trial intra- and inter-cortical interactions in the visual cortex of the mouse and the monkey. The authors find that activity in one layer (in mice) or one area (in monkeys) can partially predict neural activity in another layer or area on the single-trial level in different experimental contexts. This valuable finding expands previously known contributions of stimulus-independent downstream activity to neural responses in the visual cortex by demonstrating how these change under varying visual stimuli as well as in the absence of visual stimulation. While the methodology is solid, the juxtaposition of mouse and monkey data from different modalities and at difference scales limits the interpretability of the observations and forces superficial comparisons. More in-depth focus on either data set in isolation may reveal more nuanced understanding of cortical interactions rather than trying to draw parallels between very different datasets.

Reviewed by eLife

MLIB: an easy-to-use Matlab toolbox for the analysis of extracellular spike data

1. Maik Christopher Stüttgen

Reviewed by Peer Community in Neuroscience

Dissociable neural substrates of integration and segregation in exogenous attention

1. Yu-Jie Chen
2. Ai-Su Li
3. Yang Yu
4. Su Hu
5. Xun He
6. Yang Zhang

• Curated by eLife

  eLife Assessment

  This important study uses an optimized IOR-Stroop fMRI paradigm to dissociate integration and segregation processes and to show that attentional orienting modulates conflict processing at both the semantic and response levels. The evidence is compelling, supporting the integration-segregation theory of exogenous attention in inhibition of return while also deepening our understanding of how attentional orienting shapes downstream cognitive processing. The work will therefore be of broad interest to researchers in attention and cognitive control.

Reviewed by eLife

Cortical motor activity modulates respiration and reduces apnoea in neonates

1. Coen S Zandvoort
2. Fatima Usman
3. Shellie Robinson
4. Odunayo Fatunla
5. Eleri Adams
6. Kyle TS Pattinson
7. Simon F Farmer
8. Caroline Hartley

• Curated by eLife

  eLife Assessment

  Zandvoort and colleagues have used an innovative approach to study respiration-brain coupling in the context of apnoea in human newborns. This fundamental question is supported with convincing data and analyses. Having addressed all the reviewer comments, there was a general consensus that this work will be of great interest, not only to neonatal clinicians and physiologists, but also broadly to anyone interested in brain-body interactions.

Reviewed by eLife

Neural Representation of Associative Threat Learning in Pulvinar Divisions, Lateral Geniculate Nucleus, and Mediodorsal Thalamus in Humans

1. Muhammad Badarnee
2. Zhenfu Wen
3. B Isabel Moallem
4. Stephen Maren
5. Mohammed R Milad

• Curated by eLife

  eLife Assessment

  This study provides valuable insights into the role of thalamic nuclei in associative threat and extinction learning, underpinned by a large dataset and rigorous, multipronged analyses. The evidence provided is solid, supporting the main conclusions. Minor analytical refinements notwithstanding, the manuscript will be of broad interest to researchers in learning and memory, fear, thalamic circuitry, and related mental health conditions.

Reviewed by eLife