Neuroscience

The openretina Project: Collaborative Retina Modelling Across Datasets and Species

1. Federico D’Agostino
2. Thomas Zenkel
3. Baptiste Lorenzi
4. Michaela Vystrčilová
5. Dominic Gonschorek
6. Samuel Suhai
7. Samuele Virgili
8. Alexander S. Ecker
9. Olivier Marre
10. Larissa Höfling
11. Thomas Euler
12. Matthias Bethge

• Curated by eLife

  eLife Assessment

  This manuscript presents openretina, an open-source platform that integrates retinal datasets, model training, benchmarking, and in silico analysis tools within a unified framework. The resource is valuable because it addresses long-standing challenges in reproducibility, accessibility, and cross-study comparison in computational retina research, while providing a foundation for community-driven model development and evaluation. The supporting evidence is solid, with the authors demonstrating a functional and well-documented platform across multiple datasets and species, although a clearer discussion of model interpretability, current performance limitations, and data quality standards would strengthen the resource.

Reviewed by eLife

Neurons, Muscles, and Venom: Elucidating a Neural-to-Secretory Pathway in Cephalopod Predation

1. Kim N. Kirchhoff
2. José Ramón Pardos-Blas
3. Amy Courtney
4. Belkes Stambouli
5. Andrew L. Sugarman
6. Daniel J. Vanselow
7. Melvin Williams
8. Christian Carrasco
9. Mariam Gelashvilli
10. Cecilia Cuddy
11. Praveena Naidu
12. William R. Schafer
13. Keith C. Cheng
14. Eve Seuntjens
15. Mandë Holford

Reviewed by Review Commons

Symmetric brain-liver circuits mediate lateralized regulation of hepatic glucose output in mice

1. Zhonglong Wang
2. Xiangfei Gong
3. Li Jiang
4. Ke Wang
5. Xinyuan Sun
6. Yingxi Li
7. Mengtong Ran
8. Yanshen Chen
9. Hongdong Wang
10. Xuehui Chu
11. Shun Wang
12. Junjie Wang
13. Xiao Zheng
14. Haiping Hao
15. Hao Xie

• Curated by eLife

  eLife Assessment

  This important study combines anatomical tracing, tissue clearing, and functional manipulations to demonstrate lateralized brainstem control of hepatic glucose metabolism and identify a site of sympathetic nerve crossover supplying the liver. The evidence supporting the anatomical organization of hepatic sympathetic innervation is compelling, and the functional studies provide solid support for a role of asymmetric sympathetic outflow in regulating glucose homeostasis. While some uncertainty remains regarding the contribution of sensory innervation and the extent to which these findings generalize beyond mice, the work provides an invaluable advance in understanding neural regulation of liver metabolism.

Reviewed by eLife

Visuomotor mismatch EEG responses over occipital cortex of freely moving human subjects

1. Magdalena Solyga
2. Marek Zelechowski
3. Georg B Keller

• Curated by eLife

  eLife Assessment

  This valuable study demonstrates that self-motion strongly affects neural responses to visual stimuli, comparing humans moving through a virtual environment to passive viewing. The evidence for visuomotor mismatch responses is solid, although the interpretation in terms of prediction remains somewhat preliminary. This study bridges human and rodent studies on the role of prediction in sensory processing, and is therefore expected to be of interest to a large community of neuroscientists.

Reviewed by eLife

Human Brain-Wide Activation of Sleep Rhythms

1. Haiteng Wang
2. Qihong Zou
3. Jinbo Zhang
4. Jia-Hong Gao
5. Yunzhe Liu

• Curated by eLife

  eLife Assessment

  The study presents important findings from a very rich EEG-fMRI dataset including 107 participants, which was collected during nocturnal naps. Using overall solid methods, the authors link activity in memory related brain regions (e.g., hippocampus, thalamus, and medial prefrontal cortex), as well as their functional connectivity, to the occurrence of canonical sleep rhythms (spindles and slow oscillations) during non-rapid eye movement (NREM) sleep. This work will be of broad interest to researchers studying sleep, memory, and related domains.

Reviewed by eLife

Behavioural and neurogenetic evidence for emotion primitives in the fruit fly Drosophila: insights from the Open Field Test

1. Yi Lueningschroer-Wang
2. Emilia Derksen
3. Hannah Wilde
4. Maria Steigmeier
5. Christian Wegener

• Curated by eLife

  eLife Assessment

  This useful study reports findings that support the use of the Open Field Test in Drosophila as a model to study "emotion-like states", which are behavioral responses to several stressful or aversive treatments, and resilience upon their subsequent removal. Behavioral data, by employing established stress-causing treatments and genetic manipulations, are solid. The main advance of this work over previous Drosophila work using a similar experimental setup is systematic analysis of various stressors.

Reviewed by eLife

Arm Control and its Recovery after Selective Lesions of Sensorimotor Cortex and the Red Nucleus: A Kinematic Study in Non-Human Primates

1. Anna Baines
2. Annie Poll
3. Anne ME Baker
4. John W Krakauer
5. Stuart N Baker

• Curated by eLife

  eLife Assessment

  This important study describes how selective lesions of key cortical and subcortical motor areas affect reaching actions in macaque monkeys. The results will be of interest to both basic and clinical researchers studying the neural control of movement. Kinematic analysis of movement quality is solid but could be improved by considering other metrics, especially those that relate to grasping. Evidence for the general claims related to the role of specific motor areas is incomplete because the lesions did not fully eliminate any single area while simultaneously involving neighbouring areas.

Reviewed by eLife

Concurrent category-selective neural activity across the ventral occipito-temporal cortex supports a non-hierarchical view of human visual recognition

1. Corentin Jacques
2. Jacques Jonas
3. Sophie Colnat-Coulbois
4. Bruno Rossion

• Curated by eLife

  eLife Assessment

  This important study addresses a classic debate in visual processing, using a strong method applied to an impressive dataset obtained from a rare clinical population to evaluate hierarchical models of visual object perception. The paper provides compelling evidence that the hierarchical model is only partly supported: as expected, neural responses in ventral visual cortex show increased representational selectivity for faces along the posterior-anterior axes, but the onsets of the signals do not show a temporal hierarchy, indicating more parallel processing.

Reviewed by eLife

Cell type transcriptomics reveal shared genetic mechanisms in Alzheimer’s and Parkinson’s disease

1. Anwesha Bhattacharya
2. Edward A. Fon
3. Alain Dagher
4. Yasser Iturria-Medina
5. Jo Anne Stratton
6. Chloe Savignac
7. Jack Stanley
8. Liam Hodgson
9. Badr Ait Hammou
10. David A Bennett
11. Danilo Bzdok

Reviewed by GigaScience

Decoding spine nanostructure in cultured neurons derived from mouse models of neuropsychiatric disorder reveals a schizophrenia-linked role for Ecrg4

1. Yutaro Kashiwagi
2. Qingrui Liu
3. Yasuhiro Go
4. Ryo Saito
5. Atsu Aiba
6. Takanobu Nakazawa
7. Shigeo Okabe

• Curated by eLife

  eLife Assessment

  By investigating spine nanostructure and dynamics across multiple genetic mouse models for neurodevelopmental disorders, this important study has the potential to uncover convergent or divergent synaptic phenotypes that may be specifically associated with autism versus schizophrenia risk. The imaging and overall breadth of the methods are convincing. The purely in vitro nature of the study slightly limits the generalisability of the findings, though these limitations are acknowledged and discussed in the manuscript.

Reviewed by eLife