Neurology

Lead-OR: A multimodal platform for deep brain stimulation surgery

1. Simón Oxenford
2. Jan Roediger
3. Clemens Neudorfer
4. Luka Milosevic
5. Christopher Güttler
6. Philipp Spindler
7. Peter Vajkoczy
8. Wolf-Julian Neumann
9. Andrea Kühn
10. Andreas Horn

• Curated by eLife

  Evaluation Summary:

  This manuscript is of interest to clinicians and researchers who are involved in both placement and controlling of the accuracy of the location of deep brain stimulation electrodes. The authors present a software tool combining and correlating the documentation of intraoperative neurophysiological findings with atlas and imaging data. They also show an exemplary validation of their tool in a clinical series of 52 Parkinson disease patients who underwent DBS surgery.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Trajectories of Neurologic Recovery 12 Months After Hospitalization for COVID-19

1. Jennifer A. Frontera
2. Dixon Yang
3. Chaitanya Medicherla
4. Samuel Baskharoun
5. Kristie Bauman
6. Lena Bell
7. Dhristie Bhagat
8. Steven Bondi
9. Alexander Chervinsky
10. Levi Dygert
11. Benjamin Fuchs
12. Daniel Gratch
13. Lisena Hasanaj
14. Jennifer Horng
15. Joshua Huang
16. Ruben Jauregui
17. Yuan Ji
18. D. Ethan Kahn
19. Ethan Koch
20. Jessica Lin
21. Susan Liu
22. Anlys Olivera
23. Jonathan Rosenthal
24. Thomas Snyder
25. Rebecca Stainman
26. Daniel Talmasov
27. Betsy Thomas
28. Eduard Valdes
29. Ting Zhou
30. Yingrong Zhu
31. Ariane Lewis
32. Aaron S. Lord
33. Kara Melmed
34. Sharon B. Meropol
35. Sujata Thawani
36. Andrea B. Troxel
37. Shadi Yaghi
38. Laura J. Balcer
39. Thomas Wisniewski
40. Steven Galetta

Reviewed by ScreenIT

SARS-CoV-2 mRNA vaccinations fail to elicit humoral and cellular immune responses in patients with multiple sclerosis receiving fingolimod

1. Lil Meyer-Arndt
2. Julian Braun
3. Florent Fauchere
4. Kanika Vanshylla
5. Lucie Loyal
6. Larissa Henze
7. Beate Kruse
8. Manuela Dingeldey
9. Karsten Jürchott
10. Maike Mangold
11. Ardit Maraj
12. Andre Braginets
13. Chotima Böttcher
14. Andreas Nitsche
15. Kathrin de la Rosa
16. Christoph Ratswohl
17. Birgit Sawitzki
18. Pavlo Holenya
19. Ulf Reimer
20. Leif E Sander
21. Florian Klein
22. Friedemann Paul
23. Judith Bellmann-Strobl
24. Andreas Thiel
25. Claudia Giesecke-Thiel

Reviewed by ScreenIT

Hospitalisation for COVID-19 predicts long lasting cerebrovascular impairment: A prospective observational cohort study

1. Kamen A Tsvetanov
2. Lennart R B Spindler
3. Emmanuel A Stamatakis
4. Virginia FJ Newcombe
5. Victoria C Lupson
6. Doris A Chatfield
7. Anne E Manktelow
8. Joanne G Outtrim
9. Anne Elmer
10. Nathalie Kingston
11. John R Bradley
12. Edward T Bullmore
13. James B Rowe
14. David K Menon
15. The Cambridge NeuroCOVID Group
16. The NIHR COVID-19 BioResource
17. The Cambridge NIHR Clinical Research Facility
18. The CITIID-NIHR BioResource COVID-19 Collaboration

Reviewed by ScreenIT

Breakthrough SARS-CoV-2 infections in MS patients on disease-modifying therapies

1. Irene Schiavetti
2. Cinzia Cordioli
3. Maria Laura Stromillo
4. Maria Teresa Ferrò
5. Alice Laroni
6. Eleonora Cocco
7. Gaia Cola
8. Livia Pasquali
9. Maria Teresa Rilla
10. Elisabetta Signoriello
11. Rosa Iodice
12. Alessia Di Sapio
13. Roberta Lanzillo
14. Francesca Caleri
15. Pietro Annovazzi
16. Antonella Conte
17. Giuseppe Liberatore
18. Francesca Ruscica
19. Renato Docimo
20. Simona Bonavita
21. Monica Ulivelli
22. Paola Cavalla
23. Francesco Patti
24. Diana Ferraro
25. Marinella Clerico
26. Paolo Immovilli
27. Massimiliano Di Filippo
28. Marco Salvetti
29. Maria Pia Sormani

Reviewed by ScreenIT

Correlation between leukocyte phenotypes and prognosis of amyotrophic lateral sclerosis

1. Can Cui
2. Caroline Ingre
3. Li Yin
4. Xia Li
5. John Andersson
6. Christina Seitz
7. Nicolas Ruffin
8. Yudi Pawitan
9. Fredrik Piehl
10. Fang Fang

• Curated by eLife

  Evaluation Summary:

  Cui et al. colleagues carried out a longitudinal analysis of blood cell counts in a cohort of patients with ALS patients. They found increased numbers of neutrophils and monocytes that negatively correlated with ALSFRS-R score, but not with rate of disease progression. In addition, increased levels in NK and central memory TH2 T cells correlated with a lower risk of death, while increased levels of CD4 CD45RA effector memory and CD8 T cells were correlated with a higher risk of death. These findings have broad implications for ALS pathogenesis and the development of immune-based ALS therapies tailored to specific immune cell populations.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Persistently reduced humoral and sustained cellular immune response from first to third SARS-CoV-2 mRNA vaccination in anti-CD20-treated multiple sclerosis patients

1. Hamza Mahmood Bajwa
2. Frederik Novak
3. Anna Christine Nilsson
4. Christian Nielsen
5. Dorte K. Holm
6. Kamilla Østergaard
7. Agnes Hauschultz Witt
8. Keld-Erik Byg
9. Isik S. Johansen
10. Kristen Mittl
11. William Rowles
12. Scott S. Zamvil
13. Riley Bove
14. Joseph J. Sabatino
15. Tobias Sejbaek

Reviewed by ScreenIT

Severe Acute Respiratory Syndrome Coronavirus 2 Third Vaccine Immune Response in Multiple Sclerosis Patients Treated with Ocrelizumab

1. Livnat Brill
2. Catarina Raposo
3. Ariel Rechtman
4. Omri Zveik
5. Netta Levin
6. Esther Oiknine‐Djian
7. Dana G. Wolf
8. Adi Vaknin‐Dembinsky

Reviewed by ScreenIT

Post-COVID-19 memory complaints: Prevalence and associated factors

1. M. Ahmed
2. S. Roy
3. M.A. Iktidar
4. S. Chowdhury
5. S. Akter
6. A.M.K. Islam
7. M.D.H. Hawlader

Reviewed by ScreenIT

Mapping dopaminergic projections in the human brain with resting-state fMRI

1. Marianne Oldehinkel
2. Alberto Llera
3. Myrthe Faber
4. Ismael Huertas
5. Jan K Buitelaar
6. Bastiaan R Bloem
7. Andre F Marquand
8. Rick C Helmich
9. Koen V Haak
10. Christian F Beckmann

• Curated by eLife

  Evaluation Summary:

  This paper provides a novel method for characterizing the functional topography of the striatum based on functional connectivity profiles. Importantly, a series of ambitious analyses provide compelling (if somewhat indirect) evidence via associations to SPECT imaging, in patient populations (Parkinson's Disease), and under drug manipulation (L-DOPA), that this organization is strongly associated with the distribution of dopamine transporter concentrations. Markers of dopamine neurophysiology and signaling, especially those available in standard, non-invasive imaging acquisitions, are of great interest across a wide number of research domains.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer # 2 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife