Molecular Biology

The Viral AlphaFold Database of monomers and homodimers reveals conserved protein folds in viruses of bacteria, archaea, and eukaryotes

1. Roni Odai
2. Michèle Leemann
3. Tamim Al-Murad
4. Minhal Abdullah
5. Lena Shyrokova
6. Tanel Tenson
7. Vasili Hauryliuk
8. Janani Durairaj
9. Joana Pereira
10. Gemma C. Atkinson

Reviewed by Arcadia Science

tRNA synthetase activity is required for stress granule and P-body assembly

1. Max Baymiller
2. Noah S. Helton
3. Benjamin Dodd
4. Stephanie L. Moon

Reviewed by preLights, Life Science Editors Foundation

Metabolic reprogramming by endothelial ANGPTL4 depletion protects against diabetic kidney disease

1. Swayam Prakash Srivastava
2. Han Zhou
3. Rachel Shenoi
4. Myshal Morris
5. Begoña Lainez-Mas
6. Yuta Takagaki
7. Barani Kumar Rajendran
8. Ocean Setia
9. Binod Aryal
10. Keizo Kanasaki
11. Daisuke Koya
12. Ken Inoki
13. Alan Dardik
14. Carlos Fernández-Hernando
15. Gerald I. Shulman
16. Julie E. Goodwin

Reviewed by Life Science Editors Foundation

Venomous Maggots? A first exploration of the toxin arsenal of larval stages of the horse fly Tabanus autumnalis

1. Jonas Krämer
2. Ludwig Dersch
3. Andreas Vilcinskas
4. Tim Lüddecke

Reviewed by Arcadia Science

PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

1. Roman O Fedoryshchak
2. Karim El-Bouri
3. Dhira Joshi
4. Stephane Mouilleron
5. Richard Treisman

• Curated by eLife

  eLife Assessment

  This important study reports on a basis for neurabin-mediated specification of substrate choice by protein phosphatase-1. The data from the comprehensive approach using structural, biochemical, and computational methods are compelling. This paper is broadly relevant to those investigating various cellular signaling cascades that entail phosphorylation as the main mechanism.

Reviewed by eLife

Structural basis of lipopolysaccharide translocon assembly mediated by the small lipoprotein LptM

1. Ryoji Miyazaki
2. Mai Kimoto
3. Hidetaka Kohga
4. Tomoya Tsukazaki

Reviewed by PREreview

A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia

1. Sven M. Lange
2. Robyn J. Eisert
3. Alan Brown

Reviewed by Arcadia Science

Rapid Raman spectroscopy-based test for antimicrobial resistance

1. Vladimir Mushenkov
2. Ksenia Zhigalova
3. Pavel Denisov
4. Alexey Gordeev
5. Dmitry Lukyanov
6. Vladimir Kukushkin
7. Tatiana Priputnevich
8. Elena Zavyalova

Reviewed by Arcadia Science

Autophagy Suppresses CCL2 to Preserve Appetite and Prevent Lethal Cachexia

1. Maria Ibrahim
2. Maria Gomez-Jenkins
3. Adina Scheinfeld
4. Zhengqiao Zhao
5. Eduardo Cararo Lopes
6. Akshada Sawant
7. Zhixian Hu
8. Aditya Dharani
9. Michael Sun
10. Sarah Siddiqui
11. Emily T. Mirek
12. Johan Abram-Saliba
13. Edmund C. Lattime
14. Xiaoyang Su
15. Tobias Janowitz
16. Marcus D. Goncalves
17. Steven M. Dunn
18. Yuri Pritykin
19. Tracy G. Anthony
20. Joshua D. Rabinowitz
21. Eileen White

Reviewed by Life Science Editors Foundation

Rtf1 HMD domain facilitates global histone H2B monoubiquitination and regulates morphogenesis and virulence in the meningitis-causing pathogen Cryptococcus neoformans

1. Yixuan Jiang
2. Ying Liang
3. Fujie Zhao
4. Zhenguo Lu
5. Siyu Wang
6. Yao Meng
7. Zhanxiang Liu
8. Jing Zhang
9. Youbao Zhao

• Curated by eLife

  eLife Assessment

  This is an important study that connects the polymerase-associated factor 1 complex (Paf1C) with Histone 2B monoubiquitination and the expression of genes key to virulence in Cryptococcus neoformans. The provided information is convincing and has the potential to open several opportunities to further understand the basic biology of this significant human fungal pathogen.

Reviewed by eLife