Molecular Biology

  1. PI3Kα inhibition blocks osteochondroprogenitor specification and the hyper-inflammatory response to prevent heterotopic ossification

    1. José Antonio Valer
    2. Alexandre Deber
    3. Marius Wits
    4. Carolina Pimenta-Lope
    5. Marie-José Goumans
    6. Jose Luis Rosa
    7. Gonzalo Sánchez-Duffhues
    8. Francesc Ventura

    • Curated by eLife

      eLife Assessment

      This study, which includes additional experiments in response to the reviewer comments, presents valuable findings illustrating the role of PI3Kα in heterotopic ossification in FOP model mice. The methods, data, and analyses are solid and generally support the claims although as noted by one of the reviewers, there is no data demonstrating the effect of BYL79 on cell growth, and it remains unclear whether BYL79 also inhibits the Smad2/3 pathway. While this study provides new insights into the role of the PI3Kα pathway as a therapeutic target for FOP, questions about the mechanism of BYL79 still exist.

    Reviewed by eLife

    11 evaluationsAppears in 1 listLatest version Latest activity

  2. The Viral AlphaFold Database of monomers and homodimers reveals conserved protein folds in viruses of bacteria, archaea, and eukaryotes

    1. Roni Odai
    2. Michèle Leemann
    3. Tamim Al-Murad
    4. Minhal Abdullah
    5. Lena Shyrokova
    6. Tanel Tenson
    7. Vasili Hauryliuk
    8. Janani Durairaj
    9. Joana Pereira
    10. Gemma C. Atkinson

    Reviewed by Arcadia Science

    2 evaluationsAppears in 1 listLatest version Latest activity

  3. tRNA synthetase activity is required for stress granule and P-body assembly

    1. Max Baymiller
    2. Noah S. Helton
    3. Benjamin Dodd
    4. Stephanie L. Moon

    Reviewed by preLights, Life Science Editors Foundation

    2 evaluationsAppears in 2 listsLatest version Latest activity

  4. Metabolic reprogramming by endothelial ANGPTL4 depletion protects against diabetic kidney disease

    1. Swayam Prakash Srivastava
    2. Han Zhou
    3. Rachel Shenoi
    4. Myshal Morris
    5. Begoña Lainez-Mas
    6. Yuta Takagaki
    7. Barani Kumar Rajendran
    8. Ocean Setia
    9. Binod Aryal
    10. Keizo Kanasaki
    11. Daisuke Koya
    12. Ken Inoki
    13. Alan Dardik
    14. Carlos Fernández-Hernando
    15. Gerald I. Shulman
    16. Julie E. Goodwin

    Reviewed by Life Science Editors Foundation

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Venomous Maggots? A first exploration of the toxin arsenal of larval stages of the horse fly Tabanus autumnalis

    1. Jonas Krämer
    2. Ludwig Dersch
    3. Andreas Vilcinskas
    4. Tim Lüddecke

    Reviewed by Arcadia Science

    1 evaluationAppears in 1 listLatest version Latest activity

  6. PDZ-directed substrate recruitment is the primary determinant of specific 4E-BP1 dephosphorylation by PP1-Neurabin

    1. Roman O Fedoryshchak
    2. Karim El-Bouri
    3. Dhira Joshi
    4. Stephane Mouilleron
    5. Richard Treisman

    • Curated by eLife

      eLife Assessment

      This important study reports on a basis for neurabin-mediated specification of substrate choice by protein phosphatase-1. The data from the comprehensive approach using structural, biochemical, and computational methods are compelling. This paper is broadly relevant to those investigating various cellular signaling cascades that entail phosphorylation as the main mechanism.

    Reviewed by eLife

    10 evaluationsAppears in 1 listLatest version Latest activity

  7. Structural basis of lipopolysaccharide translocon assembly mediated by the small lipoprotein LptM

    1. Ryoji Miyazaki
    2. Mai Kimoto
    3. Hidetaka Kohga
    4. Tomoya Tsukazaki

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity

  8. A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia

    1. Sven M. Lange
    2. Robyn J. Eisert
    3. Alan Brown

    Reviewed by Arcadia Science

    3 evaluationsAppears in 1 listLatest version Latest activity

  9. Rapid Raman spectroscopy-based test for antimicrobial resistance

    1. Vladimir Mushenkov
    2. Ksenia Zhigalova
    3. Pavel Denisov
    4. Alexey Gordeev
    5. Dmitry Lukyanov
    6. Vladimir Kukushkin
    7. Tatiana Priputnevich
    8. Elena Zavyalova

    Reviewed by Arcadia Science

    5 evaluationsAppears in 1 listLatest version Latest activity

  10. Autophagy Suppresses CCL2 to Preserve Appetite and Prevent Lethal Cachexia

    1. Maria Ibrahim
    2. Maria Gomez-Jenkins
    3. Adina Scheinfeld
    4. Zhengqiao Zhao
    5. Eduardo Cararo Lopes
    6. Akshada Sawant
    7. Zhixian Hu
    8. Aditya Dharani
    9. Michael Sun
    10. Sarah Siddiqui
    11. Emily T. Mirek
    12. Johan Abram-Saliba
    13. Edmund C. Lattime
    14. Xiaoyang Su
    15. Tobias Janowitz
    16. Marcus D. Goncalves
    17. Steven M. Dunn
    18. Yuri Pritykin
    19. Tracy G. Anthony
    20. Joshua D. Rabinowitz
    21. Eileen White

    Reviewed by Life Science Editors Foundation

    1 evaluationAppears in 1 listLatest version Latest activity
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