Molecular Biology

  1. Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro

    1. Mikhail A. Hameedi
    2. Erica T. Prates
    3. Michael R. Garvin
    4. Irimpan I. Mathews
    5. B. Kirtley Amos
    6. Omar Demerdash
    7. Mark Bechthold
    8. Mamta Iyer
    9. Simin Rahighi
    10. Daniel W. Kneller
    11. Andrey Kovalevsky
    12. Stephan Irle
    13. Van-Quan Vuong
    14. Julie C. Mitchell
    15. Audrey Labbe
    16. Stephanie Galanie
    17. Soichi Wakatsuki
    18. Daniel Jacobson

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. SARS-CoV-2 RdRp uses NDPs as a substrate and is able to incorporate NHC into RNA from diphosphate form molnupiravir

    1. Maofeng Wang
    2. Cancan Wu
    3. Nan Liu
    4. Fengyu Zhang
    5. Hongjie Dong
    6. Shuai Wang
    7. Min Chen
    8. Xiaoqiong Jiang
    9. Kundi Zhang
    10. Lichuan Gu

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Molecular signature of postmortem lung tissue from COVID-19 patients suggests distinct trajectories driving mortality

    1. Anshul Budhraja
    2. Anubhav Basu
    3. Atish Gheware
    4. Dasari Abhilash
    5. Seesandra Rajagopala
    6. Suman Pakala
    7. Madhuresh Sumit
    8. Animesh Ray
    9. Arulselvi Subramaniam
    10. Purva Mathur
    11. Aruna Nambirajan
    12. Sachin Kumar
    13. Ritu Gupta
    14. Naveet Wig
    15. Anjan Trikha
    16. Randeep Guleria
    17. Chitra Sarkar
    18. Ishaan Gupta
    19. Deepali Jain

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. SARS-CoV-2 infection in free-ranging white-tailed deer ( Odocoileus virginianus )

    1. Vanessa L. Hale
    2. Patricia M. Dennis
    3. Dillon S. McBride
    4. Jaqueline M. Nolting
    5. Christopher Madden
    6. Devra Huey
    7. Margot Ehrlich
    8. Jennifer Grieser
    9. Jenessa Winston
    10. Dusty Lombardi
    11. Stormy Gibson
    12. Linda Saif
    13. Mary L. Killian
    14. Kristina Lantz
    15. Rachel Tell
    16. Mia Torchetti
    17. Suelee Robbe-Austerman
    18. Martha I. Nelson
    19. Seth A. Faith
    20. Andrew S. Bowman

    Reviewed by ScreenIT, NCRC

    2 evaluationsAppears in 3 listsLatest version Latest activity

  5. RNA-Seq is not required to determine stable reference genes for qPCR normalization

    1. Nirmal Kumar Sampathkumar
    2. Venkat Krishnan Sundaram
    3. Prakroothi S. Danthi
    4. Rasha Barakat
    5. Shiden Solomon
    6. Mrityunjoy Mondal
    7. Ivo Carre
    8. Tatiana El Jalkh
    9. Aïda Padilla-Ferrer
    10. Julien Grenier
    11. Charbel Massaad
    12. Jacqueline C. Mitchell

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  6. Rif2 protects Rap1-depleted telomeres from MRX-mediated degradation in Saccharomyces cerevisiae

    1. Fernando Rodrigo Rosas Bringas
    2. Sonia Stinus
    3. Pien de Zoeten
    4. Marita Cohn
    5. Michael Chang

    • Curated by eLife

      Evaluation Summary:

      This study investigates the tolerance to change in the sequence of telomere repeats, by analyzing a strain expressing mutant TLC1, the RNA component of the telomerase. The authors conclude that Rif2 protects telomere ends in the absence of RAP1 by inhibiting MRX and promoting Rad51-dependent homologous recombination to maintain telomere homeostasis. The study clarifies the role of Rif2 in telomere homeostais and describes how cells can extend telomeres and control senescence in the absence of Rap1 binding to telomeres. The possibility of coping with telomere sequence modification through flexibility and redundancy of capping proteins is of general interest in terms of telomere evolution.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  7. Exploring functional protein covariation across single cells using nPOP

    1. Andrew Leduc
    2. R. Gray Huffman
    3. Joshua Cantlon
    4. Saad Khan
    5. Nikolai Slavov

    Reviewed by ASAPbio crowd review

    1 evaluationAppears in 1 listLatest version Latest activity

  8. A rapid bead-based assay for screening of SARS-CoV-2 neutralizing antibodies

    1. Santhik Subhasingh Lupitha
    2. Pramod Darvin
    3. Aneesh Chandrasekharan
    4. Shankara Narayanan Varadarajan
    5. Soumya Jaya Divakaran
    6. Sreekumar Easwaran
    7. Shijulal Nelson-Sathi
    8. Perunthottathu K Umasankar
    9. Sara Jones
    10. Iype Joseph
    11. Madhavan Radhakrishna Pillai
    12. Thankayyan Retnabai Santhoshkumar

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids

    1. Yotam Menuchin-Lasowski
    2. André Schreiber
    3. Aarón Lecanda
    4. Angeles Mecate-Zambrano
    5. Linda Brunotte
    6. Olympia E. Psathaki
    7. Stephan Ludwig
    8. Thomas Rauen
    9. Hans R. Schöler

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Secondary Structure of Subgenomic RNA M of SARS-CoV-2

    1. Marta Soszynska-Jozwiak
    2. Agnieszka Ruszkowska
    3. Ryszard Kierzek
    4. Collin A. O’Leary
    5. Walter N. Moss
    6. Elzbieta Kierzek

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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