Molecular Biology

Proteomic Analysis of Human Milk Reveals Nutritional and Immune Benefits in the Colostrum from Mothers with COVID-19

1. Juanjuan Guo
2. Minjie Tan
3. Jing Zhu
4. Ye Tian
5. Huanyu Liu
6. Fan Luo
7. Jianbin Wang
8. Yanyi Huang
9. Yuanzhen Zhang
10. Yuexin Yang
11. Guanbo Wang

Reviewed by ScreenIT

Mouse models of COVID-19 recapitulate inflammatory pathways rather than gene expression

1. Cameron R. Bishop
2. Troy Dumenil
3. Daniel J. Rawle
4. Thuy T. Le
5. Kexin Yan
6. Bing Tang
7. Gunter Hartel
8. Andreas Suhrbier

Reviewed by ScreenIT

Multi-omic rejuvenation of human cells by maturation phase transient reprogramming

1. Diljeet Gill
2. Aled Parry
3. Fátima Santos
4. Hanneke Okkenhaug
5. Christopher D Todd
6. Irene Hernando-Herraez
7. Thomas M Stubbs
8. Inês Milagre
9. Wolf Reik

• Curated by eLife

  Evaluation Summary:

  This study describes a novel "maturation phase transient reprogramming" (MPTR) method to restore the epigenome of cells to a more youthful state. The authors demonstrate the effectiveness of the method to reverse several age-related changes including remodeling of the transcriptome. The method appears to peform favorably compared to other transient reprogramming protocols, and the study will be of interest to developmental biologists as well as researchers that study ageing.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Discovery and functional interrogation of SARS-CoV-2 protein-RNA interactions

1. Joy S. Xiang
2. Jasmine R. Mueller
3. En-Ching Luo
4. Brian A. Yee
5. Danielle Schafer
6. Jonathan C. Schmok
7. Frederick E. Tan
8. Katherine Rothamel
9. Rachael N. McVicar
10. Elizabeth M. Kwong
11. Krysten L. Jones
12. Hsuan-Lin Her
13. Chun-Yuan Chen
14. Anthony Q. Vu
15. Wenhao Jin
16. Samuel S. Park
17. Phuong Le
18. Kristopher W. Brannan
19. Eric R. Kofman
20. Yanhua Li
21. Alexandra T. Tankka
22. Kevin D. Dong
23. Yan Song
24. Aaron F. Carlin
25. Eric L. Van Nostrand
26. Sandra L. Leibel
27. Gene W. Yeo

Reviewed by ScreenIT

Targeted Down Regulation Of Core Mitochondrial Genes During SARS-CoV-2 Infection

1. Joseph W. Guarnieri
2. Joseph M. Dybas
3. Hossein Fazelinia
4. Man S. Kim
5. Justin Frere
6. Yuanchao Zhang
7. Yentli Soto Albrecht
8. Deborah G. Murdock
9. Alessia Angelin
10. Larry N. Singh
11. Scott L. Weiss
12. Sonja M. Best
13. Marie T. Lott
14. Henry Cope
15. Viktorija Zaksas
16. Amanda Saravia-Butler
17. Cem Meydan
18. Jonathan Foox
19. Christopher Mozsary
20. Yared H. Kidane
21. Waldemar Priebe
22. Mark R. Emmett
23. Robert Meller
24. Urminder Singh
25. Yaron Bram
26. Benjamin R. tenOever
27. Mark T. Heise
28. Nathaniel J. Moorman
29. Emily A. Madden
30. Sharon A. Taft-Benz
31. Elizabeth J. Anderson
32. Wes A. Sanders
33. Rebekah J. Dickmander
34. Victoria K. Baxter
35. Stephen B. Baylin
36. Eve Syrkin Wurtele
37. Pedro M. Moraes-Vieira
38. Deanne Taylor
39. Christopher E. Mason
40. Jonathan C. Schisler
41. Robert E. Schwartz
42. Afshin Beheshti
43. Douglas C. Wallace

Reviewed by ScreenIT

Genomic characterization of SARS-CoV-2 from Islamabad, Pakistan by Rapid Nanopore sequencing

1. Nazish Badar
2. Aamer Ikram
3. Muhammad Salman
4. Massab Umair
5. Zaira Rehman
6. Abdul Ahad
7. Hamza Ahmed Mirza
8. Masroor Alam
9. Nayab mehmood
10. Uzma Bashir

Reviewed by ScreenIT

Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer’s model

1. Felicia Reinitz
2. Elizabeth Y Chen
3. Benedetta Nicolis di Robilant
4. Bayarsaikhan Chuluun
5. Jane Antony
6. Robert C Jones
7. Neha Gubbi
8. Karen Lee
9. William Hai Dang Ho
10. Sai Saroja Kolluru
11. Dalong Qian
12. Maddalena Adorno
13. Katja Piltti
14. Aileen Anderson
15. Michelle Monje
16. H Craig Heller
17. Stephen R Quake
18. Michael F Clarke

• Curated by eLife

  Evaluation Summary:

  This is interesting and potentially impactful work uncovering mechanisms of stem cell exhaustion and impaired self-renewal that precede inflammatory phenotypes in Alzheimer's disease. The authors describe a mechanism converging on BMP signaling that may represent an early therapeutic target. The reviewers of this manuscript were excited about the potential impact but had some concerns which, if addressed, will strengthen the conclusions reached in this work.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Omicron Spike Protein Has a Positive Electrostatic Surface That Promotes ACE2 Recognition and Antibody Escape

1. Hin Hark Gan
2. John Zinno
3. Fabio Piano
4. Kristin C. Gunsalus

Reviewed by ScreenIT

SARS-CoV-2 Nsp1 N-terminal and linker regions as a platform for host translational shutoff

1. Andrea Graziadei
2. Fabian Schildhauer
3. Christian Spahn
4. Matthew Kraushar
5. Juri Rappsilber

Reviewed by ScreenIT

An efficient and cost-effective method for directed mutagenesis at multiple dispersed sites—a case study with Omicron Spike DNA

1. Rita Rani
2. Kishore V L Parsa
3. Kiranam Chatti
4. Aarti Sevilimedu

Reviewed by ScreenIT