Molecular Biology

  1. BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism

    1. Zhiwang Zhang
    2. Qichao Liao
    3. Tingli Pan
    4. Lin Yu
    5. Zupeng Luo
    6. Songtao Su
    7. Shi Liu
    8. Menglong Hou
    9. Yixing Li
    10. Turtushikh Damba
    11. Yunxiao Liang
    12. Lei Zhou

    • Curated by eLife

      eLife assessment

      This valuable study presents reports on the role of the transcription factor BATF and its target PD1 in lipid metabolism including a model of nonalcoholic fatty liver disease (NAFLD). Overall, the evidence supporting the conclusions is convincing. The work will be of interest to medical biologists working on NAFLD.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity

  2. A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells

    1. Sana Ahmed-Seghir
    2. Manisha Jalan
    3. Helen E Grimsley
    4. Aman Sharma
    5. Shyam Twayana
    6. Settapong T Kosiyatrakul
    7. Christopher Thompson
    8. Carl L Schildkraut
    9. Simon N Powell

    • Curated by eLife

      eLife assessment

      This manuscript reports important data on the cellular response to a single site-specific replication fork block in human MCF7 cells. Compelling evidence shows the efficacy of the bacterial Tus-Ter system to stall replication forks in human cells. Fork stalling let to lasting ATR-dependent phosphorylation of histone H2AX but not of ATR itself and its downstream targets RPA and CHK1.

    Reviewed by eLife

    6 evaluationsAppears in 1 listLatest version Latest activity

  3. Defining amino acid pairs as structural units suggests mutation sensitivity to adjacent residues

    1. Aviv A. Rosenberg
    2. Nitsan Yehishalom
    3. Ailie Marx
    4. Alex Bronstein

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity

  4. lncRNA read-through regulates the BX-C insulator Fub-1

    1. Airat Ibragimov
    2. Xin Yang Bing
    3. Yulii V Shidlovskii
    4. Michael Levine
    5. Pavel Georgiev
    6. Paul Schedl

    • Curated by eLife

      eLife assessment

      This fundamental work substantially advances our understanding of how neighboring genes on a chromosome can be separately controlled in time and space. The evidence supporting the conclusions is compelling, with state-of-the-art genetic perturbations and imaging. The work will be of broad interest to geneticists and cell biologists.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  5. Inhibition of type I PRMTs reforms muscle stem cell identity enhancing their therapeutic capacity

    1. Claudia Dominici
    2. Oscar D Villarreal
    3. Junio Dort
    4. Emilie Heckel
    5. Yu Chang Wang
    6. Ioannis Ragoussis
    7. Jean-Sebastien Joyal
    8. Nicolas Dumont
    9. Stéphane Richard

    • Curated by eLife

      eLife assessment

      This valuable paper informs on the role of type I PRMTs in programming muscle stem cell identification. The evidence presented is mostly solid, with some weaknesses in the evidence regarding the proposed mechanism. The paper will be of particular interest to those who study skeletal muscle satellite cell biology.

    Reviewed by eLife, Arcadia Science

    12 evaluationsAppears in 2 listsLatest version Latest activity

  6. CRISPR/Cas9 mediated gene editing in non-model nematode Panagrolaimus sp. PS1159

    1. Viktoria Hellekes
    2. Denise Claus
    3. Johanna Seiler
    4. Felix Illner
    5. Philipp H. Schiffer
    6. Michael Kroiher

    Reviewed by Arcadia Science

    16 evaluationsAppears in 1 listLatest version Latest activity

  7. A novel eukaryotic RdRP-dependent small RNA pathway represses antiviral immunity by controlling an ERK pathway component in the black-legged tick

    1. Canran Feng
    2. Kyosuke Torimaru
    3. Mandy Yu Theng Lim
    4. Li-Ling Chak
    5. Masami Shiimori
    6. Kosuke Tsuji
    7. Tetsuya Tanaka
    8. Junko Iida
    9. Katsutomo Okamura

    Reviewed by Arcadia Science

    6 evaluationsAppears in 1 listLatest version Latest activity

  8. Iterative immunostaining combined with expansion microscopy and image processing reveals nanoscopic network organization of nuclear lamina

    1. Elina Mäntylä
    2. Toni Montonen
    3. Lucio Azzari
    4. Salla Mattola
    5. Markus Hannula
    6. Maija Vihinen-Ranta
    7. Jari Hyttinen
    8. Minnamari Vippola
    9. Alessandro Foi
    10. Soile Nymark
    11. Teemu O. Ihalainen

    Reviewed by Arcadia Science

    2 evaluationsAppears in 1 listLatest version Latest activity

  9. Exploring G-quadruplex structure in PRCC-TFE3 fusion Oncogene: Plausible use as anti cancer therapy for translocation Renal cell carcinoma (tRCC)

    1. Neha
    2. Parimal Das

    Reviewed by PREreview

    1 evaluationAppears in 2 listsLatest version Latest activity

  10. Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice

    1. Adriana C. Norris
    2. Eugenia M. Yazlovitskaya
    3. Lin Zhu
    4. Bailey S. Rose
    5. Jody C. May
    6. Katherine N. Gibson-Corley
    7. John A. McLean
    8. John M. Stafford
    9. Todd R. Graham

    Reviewed by PREreview

    1 evaluationAppears in 3 listsLatest version Latest activity
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