Molecular Biology

Deep quantitative glycoproteomics reveals gut microbiome induced remodeling of the brain glycoproteome

1. Clément M Potel
2. Mira Lea Burtscher
3. Martin Garrido-Rodriguez
4. Amber Brauer-Nikonow
5. Isabelle Becher
6. Athanasios Typas
7. Michael Zimmermann
8. Mikhail M Savitski

Reviewed by PREreview

Adenine methylation is very scarce in the Drosophila genome and not erased by the ten-eleven translocation dioxygenase

1. Manon Boulet
2. Guerric Gilbert
3. Yoan Renaud
4. Martina Schmidt-Dengler
5. Emilie Plantié
6. Romane Bertrand
7. Xinsheng Nan
8. Tomasz Jurkowski
9. Mark Helm
10. Laurence Vandel
11. Lucas Waltzer

• Curated by eLife

  eLife assessment

  This study investigates the presence of DNA adenine methylation (6mA) and the associated function of TET enzyme, a DNA methylation mark eraser, in Drosophila. The study presents valuable findings on the scarcity of 6mA in the Drosophila genome and challenges previous findings regarding the role of TET in 6mA modification. The evidence supporting the claims is solid, and the paper has the potential to stimulate re-evaluations of the significance and regulatory mechanisms of 6mA DNA modifications in Drosophila.

Reviewed by eLife

Conserved and repetitive motifs in an intrinsically disordered protein drive ⍺-carboxysome assembly

1. Julia B. Turnšek
2. Luke M. Oltrogge
3. David F. Savage

Reviewed by Arcadia Science

Hibernating ribosomes tether to mitochondria as an adaptive response to cellular stress during glucose depletion

1. Olivier Gemin
2. Maciej Gluc
3. Michael Purdy
4. Higor Rosa
5. Moritz Niemann
6. Yelena Peskova
7. Simone Mattei
8. Ahmad Jomaa

Reviewed by preLights

RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit

1. Emilie L. Cerezo
2. Thibault Houles
3. Oriane Lié
4. Marie-Kerguelen Sarthou
5. Charlotte Audoynaud
6. Geneviève Lavoie
7. Maral Halladjian
8. Sylvain Cantaloube
9. Carine Froment
10. Odile Burlet-Schiltz
11. Yves Henry
12. Philippe P. Roux
13. Anthony K. Henras
14. Yves Romeo

Reviewed by Review Commons

SUMOylation of Bonus, the Drosophila homolog of Transcription Intermediary Factor 1, safeguards germline identity by recruiting repressive chromatin complexes to silence tissue-specific genes

1. Baira Godneeva
2. Maria Ninova
3. Katalin Fejes-Toth
4. Alexei Aravin

• Curated by eLife

  eLife assessment

  This important study advances our knowledge of Drosophila Bonus, the sole ortholog of the mammalian transcriptional regulator Tif1. Solid evidence, both in vivo and in vitro, shows how SUMOylation controls the function of the Bonus protein and what the impact of SUMOylation on the function of Bonus protein in the ovary is.

Reviewed by eLife