Molecular Biology

Histones with an unconventional DNA-binding mode in vitro are major chromatin constituents in the bacterium Bdellovibrio bacteriovorus

1. Antoine Hocher
2. Shawn P. Laursen
3. Paul Radford
4. Jess Tyson
5. Carey Lambert
6. Kathryn M. Stevens
7. Alex Montoya
8. Pavel V. Shliaha
9. Mathieu Picardeau
10. R. Elizabeth Sockett
11. Karolin Luger
12. Tobias Warnecke

Reviewed by Arcadia Science

HuR modulation counteracts lipopolysaccharide response in murine macrophages

1. Isabelle Bonomo
2. Giulia Assoni
3. Valeria La Pietra
4. Giulia Canarutto
5. Elisa Facen
6. Greta Donati
7. Chiara Zucal
8. Silvia Genovese
9. Mariachiara Micaelli
10. Anna Pérez-Ràfols
11. Sergio Robbiati
12. Dimitris L. Kontoyannis
13. Marilenia De Matteo
14. Marco Fragai
15. Pierfausto Seneci
16. Luciana Marinelli
17. Daniela Arosio
18. Silvano Piazza
19. Alessandro Provenzani

Reviewed by Review Commons

Functionally distinct promoter classes initiate transcription via different mechanisms reflected in focused versus dispersed initiation patterns

1. Leonid Serebreni
2. Lisa‐Marie Pleyer
3. Vanja Haberle
4. Oliver Hendy
5. Anna Vlasova
6. Vincent Loubiere
7. Filip Nemčko
8. Katharina Bergauer
9. Elisabeth Roitinger
10. Karl Mechtler
11. Alexander Stark

Reviewed by Review Commons

Iron status influences mitochondrial disease progression in Complex I-deficient mice

1. CJ Kelly
2. Reid K Couch
3. Vivian T Ha
4. Camille M Bodart
5. Judy Wu
6. Sydney Huff
7. Nicole T Herrel
8. Hyunsung D Kim
9. Azaad O Zimmermann
10. Jessica Shattuck
11. Yu-Chen Pan
12. Matt Kaeberlein
13. Anthony S Grillo

• Curated by eLife

  eLife assessment

  This manuscript starts from the hypothesis that a model of mitochondrial disease, the NDUFS4 knockout mouse, causes iron dysregulation, and that iron status may modify the neurological phenotypes that result in the mouse. This study has the potential to inform how body iron homeostasis can modify neurological phenotypes caused by mitochondrial disease. This study will be of interest to a broad audience of neuroscientists, particularly those with an interest in mitochondrial diseases.

Reviewed by eLife

A comprehensive survey of C. elegans argonaute proteins reveals organism-wide gene regulatory networks and functions

1. Uri Seroussi
2. Andrew Lugowski
3. Lina Wadi
4. Robert X Lao
5. Alexandra R Willis
6. Winnie Zhao
7. Adam E Sundby
8. Amanda G Charlesworth
9. Aaron W Reinke
10. Julie M Claycomb

• Curated by eLife

  eLife assessment

  This impressive study presents the most comprehensive analysis of the Argonautes, their small RNA partners, their targets, and their biological functions in any species to date. The work provides new insights into Argonaute-based pathways, it includes extensive validation of existing models, and describes overall a treasure-trove of reagents and datasets for future exploration of the vast Argonaute world in C. elegans.

Reviewed by eLife

Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers

1. Jean-Philippe Defour
2. Emilie Leroy
3. Sharmila Dass
4. Thomas Balligand
5. Gabriel Levy
6. Ian C Brett
7. Nicolas Papadopoulos
8. Céline Mouton
9. Lidvine Genet
10. Christian Pecquet
11. Judith Staerk
12. Steven O Smith
13. Stefan N Constantinescu

• Curated by eLife

  eLife assessment

  This very well-written paper advances our understanding of the mechanism of activation of the thrombopoietin receptor (TpoR), a very important cytokine receptor that regulates megakaryocyte differentiation and platelet production. The authors supply an elegant combination of NMR and cell biology experiments to support their conclusions and the data are of high quality.

Reviewed by eLife

Translation of dipeptide repeat proteins in C9ORF72 ALS/FTD through unique and redundant AUG initiation codons

1. Yoshifumi Sonobe
2. Soojin Lee
3. Gopinath Krishnan
4. Yuanzheng Gu
5. Deborah Y Kwon
6. Fen-Biao Gao
7. Raymond P Roos
8. Paschalis Kratsios

• Curated by eLife

  eLife assessment

  This valuable study by Sonobe et al uses transfected cells and patient iPSC-derived neurons to define mechanisms underlying translation of the antisense C4G2 RNA strand expressed in C9orf72-associated ALS and FTD. The authors design a series of constructs to explore the start codon required to produce toxic PR and prominent PG dipeptides in disease. Using these constructs they provide solid data that translation in the PR and PG reading frames occur due to the presence of AUG codons within the 5'UTR of the RNA strand. However, in its current form the paper is incomplete and the conclusions require additional experimental support.

Reviewed by eLife

Phosphorylation of Rab29 at Ser185 regulates its localization and role in the lysosomal stress response in concert with LRRK2

1. Tadayuki Komori
2. Tomoki Kuwahara
3. Tetta Fujimoto
4. Maria Sakurai
5. Ikuko Koyama-Honda
6. Mitsunori Fukuda
7. Takeshi Iwatsubo

Reviewed by Review Commons

STAT3 promotes RNA polymerase III-directed transcription by controlling the miR-106a-5p/TP73 axis

1. Cheng Zhang
2. Shasha Zhao
3. Huan Deng
4. Shihua Zhang
5. Juan Wang
6. Xiaoye Song
7. Deen Yu
8. Yue Zhang
9. Wensheng Deng

• Curated by eLife

  eLife assessment

  The author arrive at the convincing conclusion that STAT3 expression promotes TFIIIB assembly through miR-106A-5p-mediated inhibition of TP73 expression, thereby increasing Pol III transcription, which contributes to enhanced cell proliferation. The data are very good and clearly support the proposed model.

Reviewed by eLife

Myoglobin-derived iron causes wound enlargement and impaired regeneration in pressure injuries of muscle

1. Nurul Jannah Mohamed Nasir
2. Hans Heemskerk
3. Julia Jenkins
4. Nur Hidayah Hamadee
5. Ralph Bunte
6. Lisa Tucker-Kellogg

Reviewed by Review Commons