Microbiology

Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis

1. Virender Kumar Pal
2. Ragini Agrawal
3. Srabanti Rakshit
4. Pooja Shekar
5. Diwakar Tumkur Narasimha Murthy
6. Annapurna Vyakarnam
7. Amit Singh

• Curated by eLife

  Evaluation Summary:

  In the present study Pal and colleagues provide evidence that hydrogen sulfide (H2S) inhibits HIV replication and reactivation by a variety of mechanisms including inhibition of NF-kB and and recruitment of the epigenetic silencer, YY1, to the HIV promoter. They further report that H2S helps to maintaining mitochondrial bioenergetics and redox homeostasis and suggest that inclusion of an H2S donor in current ART regimens may help to achieve a functional HIV-1 cure.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Spike mutation resilient scFv76 antibody counteracts SARS-CoV-2 lung damage upon aerosol delivery

1. Ferdinando M. Milazzo
2. Antonio Chaves-Sanjuan
3. Olga Minenkova
4. Daniela Santapaola
5. Anna M. Anastasi
6. Gianfranco Battistuzzi
7. Caterina Chiapparino
8. Antonio Rosi
9. Emilio Merlo Pich
10. Claudio Albertoni
11. Emanuele Marra
12. Laura Luberto
13. Cécile Viollet
14. Luigi G. Spagnoli
15. Anna Riccio
16. Antonio Rossi
17. M. Gabriella Santoro
18. Federico Ballabio
19. Cristina Paissoni
20. Carlo Camilloni
21. Martino Bolognesi
22. Rita De Santis

Reviewed by ScreenIT

Inhibition of major histocompatibility complex-I antigen presentation by sarbecovirus ORF7a proteins

1. Fengwen Zhang
2. Trinity M. Zang
3. Eva M. Stevenson
4. Xiao Lei
5. Dennis C. Copertino
6. Talia M. Mota
7. Julie Boucau
8. Wilfredo F. Garcia-Beltran
9. R. Brad Jones
10. Paul D. Bieniasz

Reviewed by ScreenIT

Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5

1. Qian Wang
2. Yicheng Guo
3. Sho Iketani
4. Manoj S. Nair
5. Zhiteng Li
6. Hiroshi Mohri
7. Maple Wang
8. Jian Yu
9. Anthony D. Bowen
10. Jennifer Y. Chang
11. Jayesh G. Shah
12. Nadia Nguyen
13. Zhiwei Chen
14. Kathrine Meyers
15. Michael T. Yin
16. Magdalena E. Sobieszczyk
17. Zizhang Sheng
18. Yaoxing Huang
19. Lihong Liu
20. David D. Ho

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5

1. Izumi Kimura
2. Daichi Yamasoba
3. Tomokazu Tamura
4. Naganori Nao
5. Tateki Suzuki
6. Yoshitaka Oda
7. Shuya Mitoma
8. Jumpei Ito
9. Hesham Nasser
10. Jiri Zahradnik
11. Keiya Uriu
12. Shigeru Fujita
13. Yusuke Kosugi
14. Lei Wang
15. Masumi Tsuda
16. Mai Kishimoto
17. Hayato Ito
18. Rigel Suzuki
19. Ryo Shimizu
20. MST Monira Begum
21. Kumiko Yoshimatsu
22. Kanako Terakado Kimura
23. Jiei Sasaki
24. Kaori Sasaki-Tabata
25. Yuki Yamamoto
26. Tetsuharu Nagamoto
27. Jun Kanamune
28. Kouji Kobiyama
29. Hiroyuki Asakura
30. Mami Nagashima
31. Kenji Sadamasu
32. Kazuhisa Yoshimura
33. Kotaro Shirakawa
34. Akifumi Takaori-Kondo
35. Jin Kuramochi
36. Gideon Schreiber
37. Ken J. Ishii
38. Takao Hashiguchi
39. Terumasa Ikeda
40. Akatsuki Saito
41. Takasuke Fukuhara
42. Shinya Tanaka
43. Keita Matsuno
44. Kei Sato

Reviewed by ScreenIT

Distinct antigenic properties of the SARS-CoV-2 Omicron lineages BA.4 and BA.5

1. Brian J. Willett
2. Ashwini Kurshan
3. Nazia Thakur
4. Joseph Newman
5. Maria Manali
6. Grace Tyson
7. Nicola Logan
8. Pablo R. Murcia
9. Luke B. Snell
10. Jonathan D. Edgeworth
11. Jie Zhou
12. Ksenia Sukhova
13. Gayatri Amirthalingam
14. Kevin Brown
15. Bryan Charleston
16. Michael H. Malim
17. Emma C. Thomson
18. Wendy S. Barclay
19. Dalan Bailey
20. Katie J. Doores
21. Thomas P. Peacock

Reviewed by ScreenIT

Intranasal vaccination induced cross-protective secretory IgA antibodies against SARS-CoV-2 variants with reducing the potential risk of lung eosinophilic immunopathology

1. Takuya Hemmi
2. Akira Ainai
3. Takao Hashiguchi
4. Minoru Tobiume
5. Takayuki Kanno
6. Naoko Iwata-Yoshikawa
7. Shun Iida
8. Yuko Sato
9. Sho Miyamoto
10. Akira Ueno
11. Kaori Sano
12. Shinji Saito
13. Nozomi Shiwa-Sudo
14. Noriyo Nagata
15. Koji Tamura
16. Ryosuke Suzuki
17. Hideki Hasegawa
18. Tadaki Suzuki

Reviewed by ScreenIT

Host-directed therapy with 2-deoxy-D-glucose inhibits human rhinoviruses, endemic coronaviruses, and SARS-CoV-2

1. Laxmikant Wali
2. Michael Karbiener
3. Scharon Chou
4. Vitalii Kovtunyk
5. Adam Adonyi
6. Irene Gösler
7. Ximena Contreras
8. Delyana Stoeva
9. Dieter Blaas
10. Johannes Stöckl
11. Thomas R. Kreil
12. Guido A. Gualdoni
13. Anna-Dorothea Gorki

Reviewed by ScreenIT

Further antibody escape by Omicron BA.4 and BA.5 from vaccine and BA.1 serum

1. Aekkachai Tuekprakhon
2. Jiandong Huo
3. Rungtiwa Nutalai
4. Aiste Dijokaite-Guraliuc
5. Daming Zhou
6. Helen M. Ginn
7. Muneeswaran Selvaraj
8. Chang Liu
9. Alexander J. Mentzer
10. Piyada Supasa
11. Helen M.E. Duyvesteyn
12. Raksha Das
13. Donal Skelly
14. Thomas G. Ritter
15. Ali Amini
16. Sagida Bibi
17. Sandra Adele
18. Sile Ann Johnson
19. Bede Constantinides
20. Hermione Webster
21. Nigel Temperton
22. Paul Klenerman
23. Eleanor Barnes
24. Susanna J. Dunachie
25. Derrick Crook
26. Andrew J Pollard
27. Teresa Lambe
28. Philip Goulder
29. OPTIC consortium
30. ISARIC4C consortium
31. Elizabeth E. Fry
32. Juthathip Mongkolsapaya
33. Jingshan Ren
34. David I. Stuart
35. Gavin R Screaton

Reviewed by ScreenIT

Using a reverse genetics system to generate recombinant SARS-CoV-2 expressing robust levels of reporter genes

1. Chengjin Ye
2. Luis Martinez-Sobrido

Reviewed by ScreenIT