Microbiology

  1. An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccines

    1. Stephanie N. Seifert
    2. Shuangyi Bai
    3. Stephen Fawcett
    4. Elizabeth B. Norton
    5. Kevin J. Zwezdaryk
    6. James Robinson
    7. Bronwyn Gunn
    8. Michael Letko

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. SARS-CoV-2 infection of olfactory epithelial cells and neurons drives acute lung injury and lethal COVID-19 in mice

    1. Alan T. Tang
    2. David W. Buchholz
    3. Katherine M. Szigety
    4. Brian Imbhiaka
    5. Siqi Gao
    6. Maxwell Frankfurter
    7. Min Wang
    8. Jisheng Yang
    9. Peter Hewins
    10. Patricia Mericko-Ishizuka
    11. N Adrian Leu
    12. Stephanie Sterling
    13. Isaac A. Monreal
    14. Julie Sahler
    15. Avery August
    16. Xuming Zhu
    17. Kellie A. Jurado
    18. Mingang Xu
    19. Edward E. Morrisey
    20. Sarah E. Millar
    21. Hector C. Aguilar
    22. Mark L. Kahn

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Fast bacterial growth reduces antibiotic accumulation and efficacy

    1. Urszula Łapińska
    2. Margaritis Voliotis
    3. Ka Kiu Lee
    4. Adrian Campey
    5. M Rhia L Stone
    6. Brandon Tuck
    7. Wanida Phetsang
    8. Bing Zhang
    9. Krasimira Tsaneva-Atanasova
    10. Mark AT Blaskovich
    11. Stefano Pagliara

    • Curated by eLife

      Evaluation Summary:

      This manuscript addresses mechanisms by which bacteria are able to survive and evade killing by antibiotics. Using fluorescent versions of antibiotics it studies whether if entry/efflux of the drug itself is a significant contributor to the observed variability of antibiotic activity. This study will be of interest to microbiologists and clinicians for design of better antibiotic therapies.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 2 listsLatest version Latest activity

  4. Single Immunization with Recombinant ACAM2000 Vaccinia Viruses Expressing the Spike and the Nucleocapsid Proteins Protects Hamsters against SARS-CoV-2-Caused Clinical Disease

    1. Yvon Deschambault
    2. Jessie Lynch
    3. Bryce Warner
    4. Kevin Tierney
    5. Denise Huynh
    6. Robert Vendramelli
    7. Nikesh Tailor
    8. Kathy Frost
    9. Babu Sajesh
    10. Kyle LeBlanc
    11. Christine Layne
    12. Lisa Lin
    13. Levi Tamming
    14. Daniel Beniac
    15. Stephanie Booth
    16. Michael Carpenter
    17. David Safronetz
    18. Xuguang Li
    19. Darwyn Kobasa
    20. Jingxin Cao

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection

    1. Xiaoyuan Lin
    2. Beibei Fu
    3. Yan Xiong
    4. Na Xing
    5. Weiwei Xue
    6. Dong Guo
    7. Mohamed Zaky
    8. Krishna Pavani
    9. Dusan Kunec
    10. Jakob Trimpert
    11. Haibo Wu

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Direct lysis RT-qPCR of SARS-CoV-2 in cell culture supernatant allows for fast and accurate quantification of virus, opening a vast array of applications

    1. Nicky Craig
    2. Sarah L. Fletcher
    3. Alison Daniels
    4. Caitlin Newman
    5. Marie O’Shea
    6. Amanda Warr
    7. Christine Tait-Burkard

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection

    1. Nicholas Rinkenberger
    2. Michael E Abrams
    3. Sumit K Matta
    4. John W Schoggins
    5. Neal M Alto
    6. L David Sibley

    • Curated by eLife

      Evaluation Summary:

      Toxoplasma gondii is a widespread parasite of warm blooded animals, with estimates suggesting 2 billion people are currently and chronically infected with this pathogen. Many questions remain as to how humans control and eliminate T. gondii following infection. In this manuscript, Rinkenberger et al. reveal a previously unidentified and understudied host factor, RARRES3 that promotes cell autonomous control of T. gondii in human cells. The precise mechanism of control and its in vivo relevance remain areas for additional work.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 2 listsLatest version Latest activity

  8. Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines

    1. Li Wang
    2. Markus H. Kainulainen
    3. Nannan Jiang
    4. Han Di
    5. Gaston Bonenfant
    6. Lisa Mills
    7. Michael Currier
    8. Punya Shrivastava-Ranjan
    9. Brenda M. Calderon
    10. Mili Sheth
    11. Brian R. Mann
    12. Jaber Hossain
    13. Xudong Lin
    14. Sandra Lester
    15. Elizabeth A. Pusch
    16. Joyce Jones
    17. Dan Cui
    18. Payel Chatterjee
    19. M. Harley Jenks
    20. Esther K. Morantz
    21. Gloria P. Larson
    22. Masato Hatta
    23. Jennifer L. Harcourt
    24. Azaibi Tamin
    25. Yan Li
    26. Ying Tao
    27. Kun Zhao
    28. Kristine Lacek
    29. Ashley Burroughs
    30. Wei Wang
    31. Malania Wilson
    32. Terianne Wong
    33. So Hee Park
    34. Suxiang Tong
    35. John R. Barnes
    36. Mark W. Tenforde
    37. Wesley H. Self
    38. Nathan I. Shapiro
    39. Matthew C. Exline
    40. D. Clark Files
    41. Kevin W. Gibbs
    42. David N. Hager
    43. Manish Patel
    44. Alison L. Halpin
    45. Laura K. McMullan
    46. Justin S. Lee
    47. Hongjie Xia
    48. Xuping Xie
    49. Pei-Yong Shi
    50. C. Todd Davis
    51. Christina F. Spiropoulou
    52. Natalie J. Thornburg
    53. M. Steven Oberste
    54. Vivien G. Dugan
    55. SSEV Bioinformatics Working Group
    56. Dhwani Batra
    57. Andrew S. Beck
    58. Jason Caravas
    59. Reina Chau
    60. Roxana Cintron-Moret
    61. Peter W. Cook
    62. Jonathan Gerhart
    63. Christopher A. Gulvik
    64. Norman Hassell
    65. Dakota Howard
    66. Kristen Knipe
    67. Rebecca J. Kondor
    68. Nicholas A. Kovacs
    69. Kara Moser
    70. Roopa Reddy-Nagilla
    71. Clinton R. Paden
    72. Benjamin Rambo-Martin
    73. Sandra Mathew
    74. Matthew W. Schmerer
    75. Samuel S. Shepard
    76. Philip Shirk
    77. Richard A. Stanton
    78. Thomas J. Stark
    79. Erisa Sula
    80. Kendall Tymeckia
    81. Yvette Unoarumhi
    82. Voleti Subbalakshmi
    83. Xiao-yu Zheng
    84. David E. Wentworth
    85. Bin Zhou

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. SARS-CoV-2 Virus like Particles produced by a single recombinant baculovirus generate potent neutralizing antibody that protects against variant challenge

    1. Edward Sullivan
    2. Po-Yu Sung
    3. Weining Wu
    4. Neil Berry
    5. Sarah Kempster
    6. Deborah Ferguson
    7. Neil Almond
    8. Ian M. Jones
    9. Polly Roy

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Myeloid cell-driven nonregenerative pulmonary scarring is conserved in multiple nonhuman primate species regardless of SARS-CoV-2 infection modality

    1. Alyssa C Fears
    2. Brandon J Beddingfield
    3. Nicole R Chirichella
    4. Nadia Slisarenko
    5. Stephanie Z Killeen
    6. Rachel K Redmann
    7. Kelly Goff
    8. Skye Spencer
    9. Breanna Picou
    10. Nadia Golden
    11. Duane J Bush
    12. Luis M Branco
    13. Matthew L Boisen
    14. Hongmei Gao
    15. David C Montefiori
    16. Robert V Blair
    17. Lara A Doyle-Meyers
    18. Kasi Russel-Lodrigue
    19. Nicholas J Maness
    20. Chad J Roy

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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