Microbiology

Gut bacterial dysbiosis and instability is associated with the onset of complications and mortality in COVID-19

1. David Schult
2. Sandra Reitmeier
3. Plamena Koyumdzhieva
4. Tobias Lahmer
5. Moritz Middelhoff
6. Johanna Erber
7. Jochen Schneider
8. Juliane Kager
9. Marina Frolova
10. Julia Horstmann
11. Lisa Fricke
12. Katja Steiger
13. Moritz Jesinghaus
14. Klaus-Peter Janssen
15. Ulrike Protzer
16. Klaus Neuhaus
17. Roland M. Schmid
18. Dirk Haller
19. Michael Quante

Reviewed by ScreenIT

An intestinally secreted host factor promotes microsporidia invasion of C. elegans

1. Hala Tamim El Jarkass
2. Calvin Mok
3. Michael R Schertzberg
4. Andrew G Fraser
5. Emily R Troemel
6. Aaron W Reinke

• Curated by eLife

  Evaluation Summary:

  Despite the broad impact of microsporidia on diverse animals, host factors involved in their invasion have not been characterized. The present study identifies a previously uncharacterized intestinal factor (AAIM-1) that is necessary for efficient infection of early larval stages of C. elegans. The secreted factor has a minor effect mediating resistance to pathogenic bacteria, suggesting more general impact on the susceptibility of the worm to diverse pathogens.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

SARS-CoV-2 hijacks neutralizing dimeric IgA for enhanced nasal infection and injury

1. Biao Zhou
2. Runhong Zhou
3. Jasper Fuk-Woo Chan
4. Jianwei Zeng
5. Qi Zhang
6. Shuofeng Yuan
7. Li Liu
8. Rémy Robinot
9. Sisi Shan
10. Jiwan Ge
11. Hugo Yat-Hei Kwong
12. Dongyan Zhou
13. Haoran Xu
14. Chris Chung-Sing Chan
15. Vincent Kwok-Man Poon
16. Hin Chu
17. Ming Yue
18. Ka-Yi Kwan
19. Chun-Yin Chan
20. Na Liu
21. Chris Chun-Yiu Chan
22. Kenn Ka-Heng Chik
23. Zhenglong Du
24. Ka-Kit Au
25. Haode Huang
26. Hiu-On Man
27. Jianli Cao
28. Cun Li
29. Ziyi Wang
30. Jie Zhou
31. Youqiang Song
32. Man-Lung Yeung
33. Kelvin Kai-Wang To
34. David D. Ho
35. Lisa A. Chakrabarti
36. Xinquan Wang
37. Linqi Zhang
38. Kwok-Yung Yuen
39. Zhiwei Chen

Reviewed by ScreenIT

TREM2+ and interstitial macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques

1. Amit A. Upadhyay
2. Timothy N. Hoang
3. Maria Pino
4. Arun K. Boddapati
5. Elise G. Viox
6. Michelle Y.H. Lee
7. Jacqueline Corry
8. Zachary Strongin
9. David A. Cowan
10. Elizabeth N. Beagle
11. Tristan R. Horton
12. Sydney Hamilton
13. Hadj Aoued
14. Justin L. Harper
15. Kevin Nguyen
16. Kathryn L. Pellegrini
17. Gregory K. Tharp
18. Anne Piantadosi
19. Rebecca D. Levit
20. Rama R. Amara
21. Simon M. Barratt-Boyes
22. Susan P. Ribeiro
23. Rafick P. Sekaly
24. Thomas H. Vanderford
25. Raymond F. Schinazi
26. Mirko Paiardini
27. Steven E. Bosinger

Reviewed by ScreenIT

Lung-selective Cas13d-based nanotherapy inhibits lethal SARS-CoV-2 infection by targeting host protease Ctsl

1. Zhifen Cui
2. Cong Zeng
3. Furong Huang
4. Fuwen Yuan
5. Jingyue Yan
6. Yue Zhao
7. Jiaoti Huang
8. Herman F. Staats
9. Jeffrey I. Everitt
10. Gregory D. Sempowski
11. Hongyan Wang
12. Yizhou Dong
13. Shan-Lu Liu
14. Qianben Wang

Reviewed by ScreenIT

B.1.617.3 SARS CoV-2 spike E156G/Δ157-158 mutations contribute to reduced neutralization sensitivity and increased infectivity

1. Tarun Mishra
2. Garima Joshi
3. Atul Kumar
4. Rishikesh Dalavi
5. Pankaj Pandey
6. Sanjeev Shukla
7. Ram Kumar Mishra
8. Ajit Chande

Reviewed by ScreenIT

In vitro activity of cysteamine against SARS-CoV-2 variants

1. Jess Thoene
2. Robert F. Gavin
3. Aaron Towne
4. Lauren Wattay
5. Maria Grazia Ferrari
6. Jennifer Navarrete
7. Ranajit Pal

Reviewed by ScreenIT

The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector

1. Xiaotian Tang
2. Yongguo Cao
3. Gunjan Arora
4. Jesse Hwang
5. Andaleeb Sajid
6. Courtney L Brown
7. Sameet Mehta
8. Alejandro Marín-López
9. Yu-Min Chuang
10. Ming-Jie Wu
11. Hongwei Ma
12. Utpal Pal
13. Sukanya Narasimhan
14. Erol Fikrig

• Curated by eLife

  Evaluation Summary:

  This article identifies a new metabolic pathway in ticks that Borrelia burgdorferi, the agent of Lyme disease, requires for survival. The authors show that the adiponectin receptor (ISARL) is upregulated after a blood meal and find that the tick complement C1q-like protein (C1QL3) is an ISARL ligand whose knockdown impairs spirochete colonization.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Comparison of Plaque Size, Thermal Stability, and Replication Rate among SARS-CoV-2 Variants of Concern

1. Gi Uk Jeong
2. Gun Young Yoon
3. Hyun Woo Moon
4. Wooseong Lee
5. Insu Hwang
6. Haesoo Kim
7. Kyun-Do Kim
8. Chonsaeng Kim
9. Dae-Gyun Ahn
10. Bum-Tae Kim
11. Seong-Jun Kim
12. Young-Chan Kwon

Reviewed by ScreenIT

SARS-CoV-2 Variants of Concern Infect the Respiratory Tract and Induce Inflammatory Response in Wild-Type Laboratory Mice

1. Shannon Stone
2. Hussin Alwan Rothan
3. Janhavi Prasad Natekar
4. Pratima Kumari
5. Shaligram Sharma
6. Heather Pathak
7. Komal Arora
8. Tabassum Tasnim Auroni
9. Mukesh Kumar

Reviewed by ScreenIT