Gut bacterial dysbiosis and instability is associated with the onset of complications and mortality in COVID-19
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SciScore for 10.1101/2021.10.08.463613: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Ethical Approval: All patients provided written informed consent.
IRB: The study was conducted in accordance with the declaration of Helsinki and approved by the ethics committee of the Technical University Hospital of Munich (221/20 S-SR).Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources Raw FASTQ files were processed using the NGSToolkit (https://github.com/TUM-Core-Facility-Microbiome/ngstoolkit) based on USEARCH 11[27] to generate denoised zero-radiation operational-taxonomic units (zOTUs). USEARCHsuggested: (mubiomics, RRID:SCR_006785)Based on out-of-bag … SciScore for 10.1101/2021.10.08.463613: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Ethical Approval: All patients provided written informed consent.
IRB: The study was conducted in accordance with the declaration of Helsinki and approved by the ethics committee of the Technical University Hospital of Munich (221/20 S-SR).Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources Raw FASTQ files were processed using the NGSToolkit (https://github.com/TUM-Core-Facility-Microbiome/ngstoolkit) based on USEARCH 11[27] to generate denoised zero-radiation operational-taxonomic units (zOTUs). USEARCHsuggested: (mubiomics, RRID:SCR_006785)Based on out-of-bag error rates and Gini index, the most important features were selected for each iteration using rfcv from the R package randomForest v4.6-14. randomForestsuggested: (RandomForest Package in R, RRID:SCR_015718)Results from OddPub: Thank you for sharing your data.
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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