Microbiology

S100A8 and S100A9, biomarkers of SARS-Cov2-infected patients, suppress HIV replication in primary macrophages

1. Raphael M. Oguariri
2. Terrence W. Brann
3. Joseph W. Adelsberger
4. Qian Chen
5. Suranjana Goswami
6. Anthony R. Mele
7. Tomozumi Imamichi

Reviewed by ScreenIT

Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis

1. Bryan A. Johnson
2. Yiyang Zhou
3. Kumari G. Lokugamage
4. Michelle N. Vu
5. Nathen Bopp
6. Patricia A. Crocquet-Valdes
7. Birte Kalveram
8. Craig Schindewolf
9. Yang Liu
10. Dionna Scharton
11. Jessica A. Plante
12. Xuping Xie
13. Patricia Aguilar
14. Scott C. Weaver
15. Pei-Yong Shi
16. David H. Walker
17. Andrew L. Routh
18. Kenneth S. Plante
19. Vineet D. Menachery

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Bees can be trained to identify SARS-CoV-2 infected samples

1. Evangelos Kontos
2. Aria Samimi
3. Renate W. Hakze-van der Honing
4. Jan Priem
5. Aurore Avarguès-Weber
6. Alexander Haverkamp
7. Marcel Dicke
8. Jose L. Gonzales
9. Wim H. M. van der Poel

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A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

1. Pengfei Wang
2. Ryan G. Casner
3. Manoj S. Nair
4. Jian Yu
5. Yicheng Guo
6. Maple Wang
7. Jasper F.-W. Chan
8. Gabriele Cerutti
9. Sho Iketani
10. Lihong Liu
11. Zizhang Sheng
12. Zhiwei Chen
13. Kwok-Yung Yuen
14. Peter D. Kwong
15. Yaoxing Huang
16. Lawrence Shapiro
17. David D. Ho

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The adenosine analogue prodrug ATV006 is orally bioavailable and has potent preclinical efficacy against SARS-CoV-2 and its variants

1. Liu Cao
2. Yingjun Li
3. Sidi Yang
4. Guanguan Li
5. Qifan Zhou
6. Jing Sun
7. Tiefeng Xu
8. Yujian Yang
9. Tiaozhen Zhu
10. Siyao Huang
11. Yanxi Ji
12. Feng Cong
13. Yinzhu Luo
14. Yujun Zhu
15. Hemi Luan
16. Huan Zhang
17. Jingdiao Chen
18. Xue Liu
19. Ping Wang
20. Yang Yu
21. Fan Xing
22. Bixia Ke
23. Huanying Zheng
24. Xiaoling Deng
25. Wenyong Zhang
26. Chun-Mei Li
27. Yu Zhang
28. Jincun Zhao
29. Xumu Zhang
30. Deyin Guo

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A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy

1. Allison J. Greaney
2. Tyler N. Starr
3. Rachel T. Eguia
4. Andrea N. Loes
5. Khadija Khan
6. Farina Karim
7. Sandile Cele
8. John E. Bowen
9. Jennifer K. Logue
10. Davide Corti
11. David Veesler
12. Helen Y. Chu
13. Alex Sigal
14. Jesse D. Bloom

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Clp protease and antisense RNA jointly regulate the global regulator CarD to mediate mycobacterial starvation response

1. Xinfeng Li
2. Fang Chen
3. Xiaoyu Liu
4. Jinfeng Xiao
5. Binda T Andongma
6. Qing Tang
7. Xiaojian Cao
8. Shan-Ho Chou
9. Michael Y Galperin
10. Jin He

• Curated by eLife

  Evaluation Summary:

  CarD is an RNA polymerase interacting protein that is essential for mycobacterial viability, the levels of which are important for controlling gene expression in mycobacteria during various stress conditions. This study reports two mechanisms that regulate levels of CarD under stress conditions, including starvation. The authors report that CarD levels are tightly regulated and that there was a dramatic decrease in the levels of CarD when cells switched from the nutrient-rich to the starvation condition. They discovered two synergistic mechanisms that led to this dramatic decrease in CarD. The first is SigF-dependent induction of antisense RNA of CarD (AscarD), which inhibits CarD translation and a second mechanism involving Clp protease-mediated degradation of intracellular CarD. The work will be of interest to researchers studying non-coding RNAs, microbial gene expression, physiology and stress response.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

SARS-CoV-2 variants exhibit increased kinetic stability of open spike conformations as an evolutionary strategy

1. Ziwei Yang
2. Yang Han
3. Shilei Ding
4. Andrés Finzi
5. Walther Mothes
6. Maolin Lu

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Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles

1. Wael Kamel
2. Vincenzo Ruscica
3. Azman Embarc-Buh
4. Zaydah R. de Laurent
5. Manuel Garcia-Moreno
6. Yana Demyanenko
7. Richard J. Orton
8. Marko Noerenberg
9. Meghana Madhusudhan
10. Louisa Iselin
11. Aino I. Järvelin
12. Maximilian Hannan
13. Eduardo Kitano
14. Samantha Moore
15. Andres Merits
16. Ilan Davis
17. Shabaz Mohammed
18. Alfredo Castello

Reviewed by ScreenIT

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

1. Wei Qiao
2. Hui En Lau
3. Huizhi Xie
4. Vincent Kwok-Man Poon
5. Chris Chung-Sing Chan
6. Hin Chu
7. Shuofeng Yuan
8. Terrence Tsz-Tai Yuen
9. Kenn Ka-Heng Chik
10. Jessica Oi-Ling Tsang
11. Chris Chun-Yiu Chan
12. Jian-Piao Cai
13. Cuiting Luo
14. Kwok-Yung Yuen
15. Kenneth Man-Chee Cheung
16. Jasper Fuk-Woo Chan
17. Kelvin Wai-Kwok Yeung

Reviewed by ScreenIT