Microbiology

Timing of exposure is critical in a highly sensitive model of SARS-CoV-2 transmission

1. Ketaki Ganti
2. Lucas M. Ferreri
3. Chung-Young Lee
4. Camden R. Bair
5. Gabrielle K. Delima
6. Kate E. Holmes
7. Mehul S. Suthar
8. Anice C. Lowen

Reviewed by ScreenIT

Combinatorial mRNA vaccination enhances protection against SARS-CoV-2 delta variant

1. Renee L. Hajnik
2. Jessica A. Plante
3. Yuejin Liang
4. Mohamad-Gabriel Alameh
5. Jinyi Tang
6. Chaojie Zhong
7. Awadalkareem Adam
8. Dionna Scharton
9. Grace H. Rafael
10. Yang Liu
11. Nicholas C. Hazell
12. Jiaren Sun
13. Lynn Soong
14. Pei-Yong Shi
15. Tian Wang
16. Jie Sun
17. Drew Weissman
18. Scott C. Weaver
19. Kenneth S. Plante
20. Haitao Hu

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Nanotrap Particles Improve Nanopore Sequencing of SARS-CoV-2 and Other Respiratory Viruses

1. P Andersen
2. S Barksdale
3. RA Barclay
4. N Smith
5. J Fernandes
6. K Besse
7. D Goldfarb
8. R Barbero
9. R Dunlap
10. T Jones-Roe
11. R Kelly
12. S Miao
13. C Ruhunusiri
14. A Munns
15. S Mosavi
16. L Sanson
17. D Munns
18. S Sahoo
19. O Swahn
20. K Hull
21. D White
22. K Kolb
23. F Noroozi
24. J Seelam
25. A Patnaik
26. B Lepene

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The cellular characterisation of SARS-CoV-2 spike protein in virus-infected cells using Receptor Binding Domain-binding specific human monoclonal antibodies

1. Conrad En-Zuo Chan
2. Ching-Ging Ng
3. Angeline Pei-Chew Lim
4. Shirley Lay-Kheng Seah
5. De-Hoe Chye
6. Steven Ka-Khuen Wong
7. Jie-Hui Lim
8. Vanessa Zi-Yun Lim
9. Soak-Kuan Lai
10. Pui-San Wong
11. Kok-Mun Leong
12. Yi-Chun Liu
13. Richard J Sugrue
14. Boon-Huan Tan

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Intranasal Immunization with a Vaccinia Virus Vaccine Vector Expressing Pre-Fusion Stabilized SARS-CoV-2 Spike Fully Protected Mice against Lethal Challenge with the Heavily Mutated Mouse-Adapted SARS2-N501YMA30 Strain of SARS-CoV-2

1. Karen V. Kibler
2. Mateusz Szczerba
3. Douglas Lake
4. Alexa J. Roeder
5. Masmudur Rahman
6. Brenda G. Hogue
7. Lok-Yin Roy Wong
8. Stanley Perlman
9. Yize Li
10. Bertram L. Jacobs

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Orally administered epeleuton inhibits SARS-CoV-2 viral load, replication and pathology in the Syrian Hamster model

1. John Climax
2. Moayed Hamza
3. Adam Lafferty
4. Kate Guilfoyle
5. Geert van Amerongen
6. Konrad Stadler
7. Peter Wohlsein
8. Wolfgang Baumgärtner
9. Markus Weissbach
10. David Coughlan

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Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

1. Wanwisa Dejnirattisai
2. Jiandong Huo
3. Daming Zhou
4. Jiří Zahradník
5. Piyada Supasa
6. Chang Liu
7. Helen M.E. Duyvesteyn
8. Helen M. Ginn
9. Alexander J. Mentzer
10. Aekkachai Tuekprakhon
11. Rungtiwa Nutalai
12. Beibei Wang
13. Aiste Dijokaite
14. Suman Khan
15. Ori Avinoam
16. Mohammad Bahar
17. Donal Skelly
18. Sandra Adele
19. Sile Ann Johnson
20. Ali Amini
21. Thomas Ritter
22. Chris Mason
23. Christina Dold
24. Daniel Pan
25. Sara Assadi
26. Adam Bellass
27. Nikki Omo-Dare
28. David Koeckerling
29. Amy Flaxman
30. Daniel Jenkin
31. Parvinder K Aley
32. Merryn Voysey
33. Sue Ann Costa Clemens
34. Felipe Gomes Naveca
35. Valdinete Nascimento
36. Fernanda Nascimento
37. Cristiano Fernandes da Costa
38. Paola Cristina Resende
39. Alex Pauvolid-Correa
40. Marilda M. Siqueira
41. Vicky Baillie
42. Natali Serafin
43. Zanele Ditse
44. Kelly Da Silva
45. Shabir Madhi
46. Marta C Nunes
47. Tariq Malik
48. Peter JM Openshaw
49. J Kenneth Baillie
50. Malcolm G Semple
51. Alain R Townsend
52. Kuan-Ying A. Huang
53. Tiong Kit Tan
54. Miles W. Carroll
55. Paul Klenerman
56. Eleanor Barnes
57. Susanna J. Dunachie
58. Bede Constantinides
59. Hermione Webster
60. Derrick Crook
61. Andrew J Pollard
62. Teresa Lambe
63. OPTIC consortium
64. ISARIC4C consortium
65. Neil G. Paterson
66. Mark A. Williams
67. David R. Hall
68. Elizabeth E. Fry
69. Juthathip Mongkolsapaya
70. Jingshan Ren
71. Gideon Schreiber
72. David I. Stuart
73. Gavin R Screaton

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Loss of Neutralizing Antibody Response to mRNA Vaccination against SARS-CoV-2 Variants: Differing Kinetics and Strong Boosting by Breakthrough Infection

1. John P. Evans
2. Cong Zeng
3. Claire Carlin
4. Gerard Lozanski
5. Linda J. Saif
6. Eugene M. Oltz
7. Richard J. Gumina
8. Shan-Lu Liu

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An antibody-escape estimator for mutations to the SARS-CoV-2 receptor-binding domain

1. Allison J Greaney
2. Tyler N Starr
3. Jesse D Bloom

Reviewed by ScreenIT

Lytic transglycosylases mitigate periplasmic crowding by degrading soluble cell wall turnover products

1. Anna Isabell Weaver
2. Laura Alvarez
3. Kelly M Rosch
4. Asraa Ahmed
5. Garrett Sean Wang
6. Michael S van Nieuwenhze
7. Felipe Cava
8. Tobias Dörr

• Curated by eLife

  Evaluation Summary:

  This study addresses a major missing element in the understanding of how bacteria grow their cell wall and the role of lytic transglycosylases in this process. It had been previously assumed these enzymes cut glycan strands to make room for the insertion of new glycans. However, results presented in this manuscript demonstrate these enzymes have a very different, yet essential role in degrading uncrosslinked glycan strands in the periplasm. The authors further demonstrate that in the absence of lytic transglycosylases, cells undergo periplasmic stress due a toxic accumulation of these "free strands" in the periplasm. The work will be of interest to those in the bacterial growth and division field.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife