Microbiology

Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants

1. Jared Pitts
2. Jiani Li
3. Jason K. Perry
4. Venice Du Pont
5. Nicholas Riola
6. Lauren Rodriguez
7. Xianghan Lu
8. Chaitanya Kurhade
9. Xuping Xie
10. Gregory Camus
11. Savrina Manhas
12. Ross Martin
13. Pei-Yong Shi
14. Tomas Cihlar
15. Danielle P. Porter
16. Hongmei Mo
17. Evguenia Maiorova
18. John P. Bilello

Reviewed by ScreenIT

Dual Inhibition of Cathepsin L and 3CL-Pro by GC-376 Constrains SARS Cov2 Infection Including Omicron Variant

1. Prabhakaran Kumar
2. Kiira M Ratia
3. Justin M Richner
4. Gregory R J Thatcher
5. Rashmi Kadam
6. Sandra P Smieszek
7. Bartlomiej P Przychodzen
8. Vuk Koprivica
9. Gunther Birznieks
10. Mihael H Polymeropoulos
11. Bellur S Prabhakar

Reviewed by ScreenIT

Host casein kinase 1-mediated phosphorylation modulates phase separation of a rhabdovirus phosphoprotein and virus infection

1. Xiao-Dong Fang
2. Qiang Gao
3. Ying Zang
4. Ji-Hui Qiao
5. Dong-Min Gao
6. Wen-Ya Xu
7. Ying Wang
8. Dawei Li
9. Xian-Bing Wang

• Curated by eLife

  Evaluation Summary:

  Recently liquid-liquid phase separation (LLPS) has emerged as a mechanism by which membraneless compartments are formed inside the cells to compartmentalize biomolecules. In this paper, the authors show that the P protein from a plant-infecting negative sense RNA virus undergoes LLPS to promote virus replication. The host casein kinase 1 phosphorylates P protein and inhibits phase separation and viral replication. This paper will be of interest to virologists and researchers who study LLPS.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Noisy metabolism can promote microbial cross-feeding

1. Jaime G Lopez
2. Ned S Wingreen

• Curated by eLife

  Evaluation Summary:

  This paper will be of broad interest to microbiologists interested in gene expression noise and/or metabolic interactions in microbial communities. It provides a novel hypothesis that complements existing theoretical frameworks. The hypothesis is well supported by data from a mathematical model, and it its predictions could be tested experimentally in future work.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

N-acylethanolamine acid amide hydrolase is a novel target for drugs against SARS-CoV-2 and Zika virus

1. Michele Lai
2. Veronica La Rocca
3. Rachele Amato
4. Elena Iacono
5. Carolina Filipponi
6. Elisa Catelli
7. Lucia Bogani
8. Rossella Fonnesu
9. Giulia Lottini
10. Alessandro De Carli
11. Alessandro Mengozzi
12. Stefano Masi
13. Paola Quaranta
14. Pietro Giorgio Spezia
15. Giulia Freer
16. Paola Lenzi
17. Francesco Fornai
18. Daniele Piomelli
19. Mauro Pistello

Reviewed by ScreenIT

SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export

1. Ross Hall
2. Anabel Guedán
3. Melvyn W. Yap
4. George R. Young
5. Ruth Harvey
6. Jonathan P. Stoye
7. Kate N. Bishop

Reviewed by ScreenIT

Boosting with Omicron-matched or historical mRNA vaccines increases neutralizing antibody responses and protection against B.1.1.529 infection in mice

1. Baoling Ying
2. Suzanne M. Scheaffer
3. Bradley Whitener
4. Chieh-Yu Liang
5. Oleksandr Dmytrenko
6. Samantha Mackin
7. Kai Wu
8. Diana Lee
9. Laura E. Avena
10. Zhenlu Chong
11. James Brett Case
12. LingZhi Ma
13. Thu Kim
14. Caralyn Sein
15. Angela Woods
16. Daniela Montes Berrueta
17. Andrea Carfi
18. Sayda M. Elbashir
19. Darin K. Edwards
20. Larissa B. Thackray
21. Michael S. Diamond

Reviewed by ScreenIT

Antibody evasion properties of SARS-CoV-2 Omicron sublineages

1. Sho Iketani
2. Lihong Liu
3. Yicheng Guo
4. Liyuan Liu
5. Jasper F.-W. Chan
6. Yiming Huang
7. Maple Wang
8. Yang Luo
9. Jian Yu
10. Hin Chu
11. Kenn K.-H. Chik
12. Terrence T.-T. Yuen
13. Michael T. Yin
14. Magdalena E. Sobieszczyk
15. Yaoxing Huang
16. Kwok-Yung Yuen
17. Harris H. Wang
18. Zizhang Sheng
19. David D. Ho

Reviewed by ScreenIT

Distinguishing different modes of growth using single-cell data

1. Prathitha Kar
2. Sriram Tiruvadi-Krishnan
3. Jaana Männik
4. Jaan Männik
5. Ariel Amir

• Curated by eLife

  Evaluation Summary:

  This manuscript will be of interest to the community of quantitative biologists aiming to understand the basic mechanisms of cell growth. By demonstrating, and then resolving, the problem that a common test for exponential growth can make exponential growth appear non-exponential, and can make linear growth appear exponential, the authors introduce valuable insights and analysis tools to this active field.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

A highly attenuated SARS-CoV-2 related pangolin coronavirus variant has a 104nt deletion at the 3′-terminus untranslated region

1. Shanshan Lu
2. Shengdong Luo
3. Chang Liu
4. Muli Li
5. Xiaoping An
6. Mengzhe Li
7. Jun Hou
8. Huahao Fan
9. Panyong Mao
10. Yigang Tong
11. Lihua Song

Reviewed by ScreenIT